hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09950.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
ABCB9	ABC-type oligopeptide transporter ABCB9 (EC 7.4.2.6) (ATP-binding cassette sub-family B member 9) (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)	5	UniProt NCBI
POR	NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)	5	UniProt NCBI
ABCC2	ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)	5	UniProt NCBI
CLCN4	H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4)	5	UniProt NCBI
ARFGEF1	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)	5	UniProt NCBI
CYP26B1	Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome)	5	UniProt NCBI
GGA2	ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)	5	UniProt NCBI
EPHX1	Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH)	5	UniProt NCBI
CLCN5	H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)	5	UniProt NCBI
ADCY3	Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)	5	UniProt NCBI
TMEM9B	Transmembrane protein 9B	5	UniProt NCBI
ABCA3	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	5	UniProt NCBI
GGA1	ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)	5	UniProt NCBI
CLCN3	H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-382551	3.19635624804e-05	0.538461538462	ABCB9 CLCN4 ADCY3 CLCN3 ABCA3 ABCC2 CLCN5	Transport of small molecules
KEGG:02010	0.000185244758338	0.230769230769	ABCB9 ABCA3 ABCC2	ABC transporters
GO:0031090	0.000300035048164	0.923076923077	ABCB9 GGA2 GGA1 TMEM9B CLCN4 ADCY3 CLCN3 CLCN5 CYP26B1 ARFGEF1 EPHX1 ABCA3	organelle membrane
KEGG:04976	0.000943491618216	0.230769230769	ABCC2 EPHX1 ADCY3	Bile secretion
GO:0098588	0.000943900091301	0.769230769231	ABCB9 GGA2 GGA1 TMEM9B CLCN4 ADCY3 CLCN3 ABCA3 CLCN5 ARFGEF1	bounding membrane of organelle
GO:0005247	0.000960187650128	0.230769230769	CLCN4 CLCN3 CLCN5	voltage-gated chloride channel activity
GO:0005769	0.0028947497907	0.461538461538	TMEM9B GGA2 CLCN4 GGA1 CLCN5 CLCN3	early endosome
GO:0022804	0.00315911494827	0.461538461538	ABCB9 CLCN4 ABCA3 ABCC2 CLCN5 CLCN3	active transmembrane transporter activity
GO:0008308	0.00601998990141	0.230769230769	CLCN4 CLCN3 CLCN5	voltage-gated monoatomic anion channel activity
REAC:R-HSA-2672351	0.00635592495791	0.230769230769	CLCN4 CLCN3 CLCN5	Stimuli-sensing channels
WP:WP5238	0.0066188060903	0.153846153846	ABCC2 EPHX1	Cholestasis
KEGG:04142	0.00894909134625	0.230769230769	ABCB9 GGA2 GGA1	Lysosome
GO:0012505	0.0101149479965	0.923076923077	ABCB9 GGA2 GGA1 TMEM9B CLCN4 ADCY3 CLCN3 CLCN5 CYP26B1 ARFGEF1 EPHX1 ABCA3	endomembrane system
GO:0010008	0.0117403828618	0.461538461538	TMEM9B GGA2 CLCN4 GGA1 CLCN5 CLCN3	endosome membrane
KEGG:04613	0.0157645406863	0.230769230769	CLCN4 CLCN3 CLCN5	Neutrophil extracellular trap formation
REAC:R-HSA-382556	0.0192161959375	0.230769230769	ABCB9 ABCA3 ABCC2	ABC-family proteins mediated transport
WP:WP3612	0.0195135093394	0.153846153846	ABCC2 EPHX1	Photodynamic therapy induced NFE2L2 NRF2 survival signaling
GO:0140359	0.0310665990836	0.230769230769	ABCB9 ABCA3 ABCC2	ABC-type transporter activity
GO:0015103	0.0366003090215	0.307692307692	ABCC2 CLCN3 CLCN5 CLCN4	inorganic anion transmembrane transporter activity
GO:0005768	0.0407741105849	0.538461538462	TMEM9B GGA2 CLCN4 GGA1 ABCA3 CLCN3 CLCN5	endosome
REAC:R-HSA-983712	0.0437776143293	0.230769230769	CLCN4 CLCN3 CLCN5	Ion channel transport

Edges

Protein 1	Protein 2	Score	ProteomeHD
ABCA3	TMEM9B	0.999	0.114
TMEM9B	CLCN3	0.999	0.258
CLCN5	TMEM9B	0.999	0.174
CLCN3	GGA1	0.998	0.074
TMEM9B	GGA1	0.994	0.106
ARFGEF1	TMEM9B	0.994	0.058
ABCC2	CYP26B1	0.991
TMEM9B	EPHX1	0.989	0.08
GGA1	GGA2	0.988	0.066
EPHX1	CYP26B1	0.985
CLCN4	TMEM9B	0.982
ABCB9	TMEM9B	0.981
ADCY3	CYP26B1	0.977
TMEM9B	ADCY3	0.975	0.18
CLCN5	CLCN3	0.972	0.308
ABCC2	TMEM9B	0.971	0.042
POR	TMEM9B	0.968	0.07
CLCN3	CYP26B1	0.965
CLCN3	ADCY3	0.963	0.094
ABCA3	ARFGEF1	0.717	0.054
ABCA3	EPHX1	0.682	0.106
ABCA3	POR	0.663	0.056
ARFGEF1	CLCN5	0.652	0.168
CLCN4	CLCN3	0.634
CLCN4	CLCN5	0.633
CLCN4	ARFGEF1	0.633
ABCB9	CLCN3	0.592
ARFGEF1	CLCN3	0.583	0.08
ABCA3	CLCN4	0.545
ABCA3	ADCY3	0.531	0.108
ABCB9	ADCY3	0.526
ABCA3	ABCB9	0.458
ABCC2	CLCN3	0.43	0.08
CLCN3	EPHX1	0.421	0.098
ABCA3	CLCN5	0.374	0.072
ABCC2	EPHX1	0.374	0.178
ABCC2	ADCY3	0.357	0.02
ABCA3	CLCN3	0.353	0.12
POR	EPHX1	0.342	0.178
ABCB9	EPHX1	0.339
ABCC2	ABCA3	0.307	0.058
ADCY3	EPHX1	0.286	0.1168
ABCC2	CLCN4	0.269
ABCC2	ABCB9	0.267
ABCB9	POR	0.266
CLCN4	ADCY3	0.22
POR	CLCN3	0.208	0.082
ABCC2	CLCN5	0.188	0.108
ABCC2	POR	0.179	0.18
CLCN4	EPHX1	0.16
ABCB9	CLCN5	0.159
CLCN5	ADCY3	0.129	0.086
POR	ADCY3	0.123	0.078
POR	CLCN4	0.093
ABCC2	ARFGEF1	0.084	0.048
CLCN5	EPHX1	0.081	0.104
ARFGEF1	EPHX1	0.077	0.064
POR	CLCN5	0.064	0.146
ARFGEF1	ADCY3	0.061	0.082
ABCB9	CLCN4	0.042
POR	ARFGEF1	0.03	0.064
ABCA3	GGA1	0.028	0.04
GGA1	EPHX1	0.025	0.018
POR	GGA1	0.02	0.092
ADCY3	GGA2	0.014	0.08
ABCB9	ARFGEF1	0.012

Related Complexes

Genename	Complexes
ABCB9	huMAP3_00895.1 huMAP3_05412.1 huMAP3_05642.1 huMAP3_07269.1 huMAP3_07866.1 huMAP3_08284.1 huMAP3_08460.1 huMAP3_08888.1 huMAP3_08979.1 huMAP3_08994.1 huMAP3_09950.1 huMAP3_11593.1 huMAP3_12877.1 huMAP3_13438.1 huMAP3_15019.1 huMAP3_15113.1
POR	huMAP3_00895.1 huMAP3_01437.1 huMAP3_01918.1 huMAP3_02883.1 huMAP3_04862.1 huMAP3_05085.1 huMAP3_05365.1 huMAP3_05642.1 huMAP3_05921.1 huMAP3_07484.1 huMAP3_07747.1 huMAP3_08637.1 huMAP3_08639.1 huMAP3_08994.1 huMAP3_09950.1 huMAP3_10008.1 huMAP3_10374.1 huMAP3_10391.1
ABCC2	huMAP3_00062.1 huMAP3_06063.1 huMAP3_08626.1 huMAP3_09950.1 huMAP3_10693.1 huMAP3_13093.1 huMAP3_14952.1 huMAP3_15113.1
CLCN4	huMAP3_00895.1 huMAP3_02848.1 huMAP3_05642.1 huMAP3_07605.1 huMAP3_08994.1 huMAP3_09950.1 huMAP3_10638.1 huMAP3_12935.1 huMAP3_14952.1
ARFGEF1	huMAP3_00895.1 huMAP3_03206.1 huMAP3_05642.1 huMAP3_08447.1 huMAP3_08994.1 huMAP3_09243.1 huMAP3_09950.1 huMAP3_10907.1 huMAP3_12406.1
CYP26B1	huMAP3_05066.1 huMAP3_07074.1 huMAP3_08626.1 huMAP3_09950.1 huMAP3_10456.1 huMAP3_15113.1
GGA2	huMAP3_02708.1 huMAP3_04386.1 huMAP3_09950.1
EPHX1	huMAP3_03090.1 huMAP3_09458.1 huMAP3_09950.1 huMAP3_15113.1
CLCN5	huMAP3_00895.1 huMAP3_01943.1 huMAP3_09950.1 huMAP3_10456.1 huMAP3_10526.1 huMAP3_10638.1 huMAP3_14952.1
ADCY3	huMAP3_02700.1 huMAP3_08506.1 huMAP3_09950.1 huMAP3_10456.1 huMAP3_11507.1 huMAP3_15113.1
TMEM9B	huMAP3_00895.1 huMAP3_05642.1 huMAP3_08994.1 huMAP3_09950.1 huMAP3_14952.1
ABCA3	huMAP3_00636.1 huMAP3_00895.1 huMAP3_05569.1 huMAP3_05642.1 huMAP3_08410.1 huMAP3_08994.1 huMAP3_09950.1 huMAP3_11420.1 huMAP3_14700.1 huMAP3_15126.1
GGA1	huMAP3_02708.1 huMAP3_04386.1 huMAP3_09950.1
CLCN3	huMAP3_02201.1 huMAP3_02342.1 huMAP3_02700.1 huMAP3_06126.1 huMAP3_07074.1 huMAP3_08376.1 huMAP3_08506.1 huMAP3_09336.1 huMAP3_09950.1 huMAP3_10456.1 huMAP3_10638.1 huMAP3_10848.1 huMAP3_11349.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09950.1