hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09951.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
CIC	Protein capicua homolog	5	UniProt NCBI
CTBP2	C-terminal-binding protein 2 (CtBP2)	5	UniProt NCBI
ZBTB42	Zinc finger and BTB domain-containing protein 42	5	UniProt NCBI
CTBP1	C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)	5	UniProt NCBI
LCORL	Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein)	4	UniProt NCBI
ZBTB18	Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171)	5	UniProt NCBI
ATXN1L	Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1)	5	UniProt NCBI
ZNF516	Zinc finger protein 516	5	UniProt NCBI
ZEB2	Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)	5	UniProt NCBI
RNF187	E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187)	5	UniProt NCBI
ZNF217	Zinc finger protein 217	5	UniProt NCBI
ZNF536	Zinc finger protein 536	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:642	5.34289012247e-11	0.416666666667	CTBP1 ZNF217 ZEB2 CTBP2 ZNF516	CtBP complex
GO:0006355	1.18648053889e-05	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of DNA-templated transcription
GO:2001141	1.27592557549e-05	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of RNA biosynthetic process
GO:0006351	2.09692159737e-05	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	DNA-templated transcription
GO:0032774	2.38427080176e-05	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	RNA biosynthetic process
GO:0051252	4.54700393555e-05	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of RNA metabolic process
GO:0034654	0.000107685766092	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	nucleobase-containing compound biosynthetic process
CORUM:2921	0.000112726824524	0.166666666667	CTBP1 CTBP2	SHARP-CtBP complex
GO:0018130	0.000134046433075	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	heterocycle biosynthetic process
GO:0019438	0.000135767407916	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	aromatic compound biosynthetic process
GO:0019219	0.000136345551597	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of nucleobase-containing compound metabolic process
GO:1901362	0.000192214509808	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	organic cyclic compound biosynthetic process
KEGG:04330	0.00037236805775	0.25	CTBP1 CTBP2 ATXN1L	Notch signaling pathway
REAC:R-HSA-5339700	0.000503594835644	0.166666666667	CTBP1 CTBP2	Signaling by TCF7L2 mutants
GO:0016070	0.000680716701073	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	RNA metabolic process
GO:0010468	0.00107753175225	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of gene expression
GO:0044271	0.00117791643864	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	cellular nitrogen compound biosynthetic process
CORUM:643	0.00134902339898	0.166666666667	CTBP1 CTBP2	CtBP core complex
GO:0010556	0.00156500365619	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of macromolecule biosynthetic process
CORUM:1492	0.00168550997432	0.166666666667	ZNF516 ZNF217	BHC110 complex
GO:0031326	0.00203785761208	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of cellular biosynthetic process
GO:0009889	0.0021878192192	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of biosynthetic process
CORUM:626	0.00291755409055	0.166666666667	CTBP1 ZNF217	LSD1 complex
GO:0090304	0.00297166088295	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	nucleic acid metabolic process
GO:0140110	0.00385303190431	0.75	CTBP1 ZBTB18 ZBTB42 ZEB2 ZNF516 ZNF536 ZNF217 CIC CTBP2	transcription regulator activity
GO:0051171	0.00553066820526	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of nitrogen compound metabolic process
GO:0080090	0.00743502252654	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of primary metabolic process
REAC:R-HSA-4641265	0.00919893032747	0.166666666667	CTBP1 CTBP2	Repression of WNT target genes
GO:0006139	0.0105304364735	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	nucleobase-containing compound metabolic process
GO:0046483	0.014939691865	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	heterocycle metabolic process
GO:0006725	0.0155072321414	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	cellular aromatic compound metabolic process
GO:0060255	0.0174291547128	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of macromolecule metabolic process
GO:0031323	0.0179298991456	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of cellular metabolic process
GO:1901360	0.0239123297085	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	organic cyclic compound metabolic process
GO:0010467	0.0250596387485	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	gene expression
GO:0006357	0.0333237547711	0.75	CTBP1 CTBP2 LCORL ZBTB42 ZEB2 ZNF536 ZNF217 CIC ZBTB18	regulation of transcription by RNA polymerase II
HP:0031432	0.0335134411772	0.333333333333	CTBP1 ZEB2 CIC ZBTB18	Restricted or repetitive behaviors or interests
HP:0000733	0.0335134411772	0.333333333333	CTBP1 ZEB2 CIC ZBTB18	Abnormal repetitive mannerisms
GO:0034641	0.0404986601216	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	cellular nitrogen compound metabolic process
WP:WP268	0.0447852947857	0.166666666667	CTBP1 CTBP2	Notch signaling
GO:0019222	0.048409275242	1.0	CTBP1 CTBP2 LCORL RNF187 ZBTB42 ZEB2 ZNF516 ATXN1L ZNF536 ZNF217 CIC ZBTB18	regulation of metabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD
CTBP1	CTBP2	0.999
CIC	ZBTB18	0.999
ZBTB18	ATXN1L	0.998
ZBTB42	CTBP2	0.998
ZNF516	CTBP1	0.998	0.188
CTBP1	ZBTB18	0.998
CTBP1	ZBTB42	0.996
ZNF516	ZBTB18	0.994
ZBTB18	CTBP2	0.993
ZBTB18	ZBTB42	0.99
CTBP1	ZNF217	0.985	0.078
LCORL	CTBP1	0.984
ZNF516	CTBP2	0.977
ZNF516	ZNF217	0.975	0.112
ZNF536	CTBP1	0.973
ZBTB42	RNF187	0.97	0.086
ZEB2	CTBP1	0.956	0.108
CIC	ATXN1L	0.883	0.19
ZNF516	ZBTB42	0.838	0.07
CTBP2	ZNF217	0.822
ZNF516	ATXN1L	0.675	0.166
ZNF536	LCORL	0.612	0.03
LCORL	ZNF516	0.594	0.134
ZNF536	ZEB2	0.587	0.116
LCORL	ZEB2	0.568	0.068
ZEB2	ZNF217	0.538	0.09
ZEB2	ZBTB18	0.513
ZNF516	CIC	0.481	0.128
ZNF516	ZEB2	0.417	0.174
LCORL	CTBP2	0.386
LCORL	ZBTB18	0.378
LCORL	ZNF217	0.378	0.054
ZNF536	ZBTB18	0.35
ATXN1L	ZBTB42	0.35	0.088
ZNF536	ZNF217	0.341	0.096
CIC	CTBP2	0.319
ZNF536	ZNF516	0.303	0.048
CIC	ZBTB42	0.303	0.074
ZEB2	CTBP2	0.3
ZNF536	CTBP2	0.263
ZBTB18	ZNF217	0.224
ZBTB18	RNF187	0.187
ZNF516	RNF187	0.143	0.148
CTBP1	ATXN1L	0.139	0.118
ATXN1L	CTBP2	0.129
ATXN1L	RNF187	0.102	0.11
CIC	RNF187	0.097	0.09
CTBP1	CIC	0.066	0.212
ZNF536	CIC	0.055	0.066
RNF187	CTBP2	0.027
CIC	ZNF217	0.022	0.074
ZEB2	CIC	0.02	0.044
CTBP1	RNF187	0.018	0.132

Related Complexes

Genename	Complexes
CIC	huMAP3_00215.1 huMAP3_04051.1 huMAP3_05086.1 huMAP3_07306.1 huMAP3_09951.1 huMAP3_12062.1 huMAP3_13266.1 huMAP3_13657.1
CTBP2	huMAP3_01722.1 huMAP3_02221.1 huMAP3_06380.1 huMAP3_08078.1 huMAP3_09626.1 huMAP3_09951.1 huMAP3_12062.1 huMAP3_15128.1
ZBTB42	huMAP3_00619.1 huMAP3_00945.1 huMAP3_01722.1 huMAP3_06380.1 huMAP3_08078.1 huMAP3_09951.1 huMAP3_12062.1
CTBP1	huMAP3_00008.1 huMAP3_01722.1 huMAP3_02221.1 huMAP3_03984.1 huMAP3_06380.1 huMAP3_06993.1 huMAP3_07713.1 huMAP3_08078.1 huMAP3_08091.1 huMAP3_08697.1 huMAP3_09626.1 huMAP3_09951.1 huMAP3_10094.1 huMAP3_11306.1 huMAP3_12062.1
LCORL	huMAP3_00008.1 huMAP3_02221.1 huMAP3_04045.1 huMAP3_06331.1 huMAP3_06529.1 huMAP3_08078.1 huMAP3_08091.1 huMAP3_08697.1 huMAP3_08806.1 huMAP3_09626.1 huMAP3_09951.1 huMAP3_10094.1 huMAP3_11306.1 huMAP3_11911.1 huMAP3_12062.1 huMAP3_14358.1
ZBTB18	huMAP3_00215.1 huMAP3_01722.1 huMAP3_05086.1 huMAP3_09951.1 huMAP3_12062.1 huMAP3_13266.1 huMAP3_13657.1
ATXN1L	huMAP3_00215.1 huMAP3_03364.1 huMAP3_05086.1 huMAP3_09951.1 huMAP3_11424.1 huMAP3_12062.1 huMAP3_12271.1 huMAP3_12363.1 huMAP3_13266.1 huMAP3_13657.1 huMAP3_14121.1 huMAP3_14161.1
ZNF516	huMAP3_00008.1 huMAP3_01722.1 huMAP3_02221.1 huMAP3_03575.1 huMAP3_05699.1 huMAP3_06380.1 huMAP3_07713.1 huMAP3_08078.1 huMAP3_08697.1 huMAP3_09031.1 huMAP3_09626.1 huMAP3_09951.1 huMAP3_10094.1 huMAP3_12062.1 huMAP3_15128.1
ZEB2	huMAP3_00008.1 huMAP3_01722.1 huMAP3_02221.1 huMAP3_03984.1 huMAP3_06380.1 huMAP3_06993.1 huMAP3_07713.1 huMAP3_08078.1 huMAP3_08091.1 huMAP3_08697.1 huMAP3_09626.1 huMAP3_09951.1 huMAP3_10094.1 huMAP3_11306.1 huMAP3_12062.1
RNF187	huMAP3_00945.1 huMAP3_03212.1 huMAP3_03490.1 huMAP3_05521.1 huMAP3_07686.1 huMAP3_09951.1 huMAP3_12354.1 huMAP3_12384.1 huMAP3_12780.1 huMAP3_14706.1
ZNF217	huMAP3_03549.1 huMAP3_03575.1 huMAP3_05699.1 huMAP3_06380.1 huMAP3_08800.1 huMAP3_09031.1 huMAP3_09168.1 huMAP3_09626.1 huMAP3_09951.1 huMAP3_10094.1 huMAP3_10311.1 huMAP3_12062.1 huMAP3_15128.1
ZNF536	huMAP3_00008.1 huMAP3_01722.1 huMAP3_02221.1 huMAP3_03984.1 huMAP3_06380.1 huMAP3_06993.1 huMAP3_07713.1 huMAP3_08078.1 huMAP3_08091.1 huMAP3_08697.1 huMAP3_09626.1 huMAP3_09951.1 huMAP3_10094.1 huMAP3_11306.1 huMAP3_12062.1 huMAP3_14358.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09951.1