hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09952.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WNK3 | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | 5 | UniProt NCBI |
| DCTN2 | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | 5 | UniProt NCBI |
| ACTR1B | Beta-centractin (Actin-related protein 1B) (ARP1B) | 5 | UniProt NCBI |
| DCTN4 | Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) | 5 | UniProt NCBI |
| ACTR10 | Actin-related protein 10 (Actin-related protein 11) (hARP11) | 4 | UniProt NCBI |
| DCTN6 | Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3) | 5 | UniProt NCBI |
| KLHL2 | Kelch-like protein 2 (Actin-binding protein Mayven) | 5 | UniProt NCBI |
| DCTN5 | Dynactin subunit 5 (Dynactin subunit p25) | 5 | UniProt NCBI |
| DEFB127 | Beta-defensin 127 (Beta-defensin 27) (DEFB-27) (Defensin, beta 127) | 5 | UniProt NCBI |
| PIK3C2B | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | 5 | UniProt NCBI |
| CPVL | Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP) | 4 | UniProt NCBI |
| ACTR1A | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | 5 | UniProt NCBI |
| DCTN3 | Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22) | 5 | UniProt NCBI |
| PDGFD | Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)] | 5 | UniProt NCBI |
| TRIM8 | E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8) | 5 | UniProt NCBI |
| DCTN1 | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005869 | 1.24885120777e-20 | 0.5 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B | dynactin complex |
| REAC:R-HSA-6811436 | 3.84147926912e-14 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 5.37931435164e-14 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| KEGG:05132 | 2.56478093647e-13 | 0.625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 PIK3C2B DCTN5 ACTR10 ACTR1B DCTN1 | Salmonella infection |
| REAC:R-HSA-2132295 | 3.15258939805e-13 | 0.5625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | MHC class II antigen presentation |
| KEGG:04814 | 1.28247006309e-12 | 0.5625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | Motor proteins |
| WP:WP5376 | 2.535405148e-12 | 0.375 | DCTN1 DCTN4 DCTN2 DCTN5 DCTN3 DCTN6 | 17p13 3 YWHAE copy number variation |
| REAC:R-HSA-6807878 | 9.27697187192e-12 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | COPI-mediated anterograde transport |
| GO:0005875 | 8.56740206749e-11 | 0.5625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | microtubule associated complex |
| REAC:R-HSA-8856688 | 8.65842658081e-11 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Golgi-to-ER retrograde transport |
| KEGG:05016 | 1.37532031403e-10 | 0.5625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | Huntington disease |
| REAC:R-HSA-199977 | 2.4291966064e-10 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | ER to Golgi Anterograde Transport |
| KEGG:05014 | 6.85660972947e-10 | 0.5625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-948021 | 1.08550482516e-09 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6811442 | 2.74972450604e-09 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| KEGG:05022 | 6.13258514538e-09 | 0.5625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | Pathways of neurodegeneration - multiple diseases |
| KEGG:04962 | 3.00326689904e-08 | 0.3125 | DCTN4 DCTN1 DCTN2 DCTN5 DCTN6 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 5.63865032492e-08 | 0.3125 | DCTN4 DCTN1 DCTN2 DCTN5 DCTN6 | Vasopressin regulated water reabsorption |
| REAC:R-HSA-446203 | 5.89289792264e-08 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-1280218 | 6.40824843565e-08 | 0.625 | DCTN6 DCTN4 ACTR1A KLHL2 DCTN2 DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | Adaptive Immune System |
| REAC:R-HSA-168256 | 1.83889811354e-06 | 0.75 | DCTN6 TRIM8 DCTN4 ACTR1A KLHL2 DCTN2 DEFB127 DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | Immune System |
| GO:0015629 | 2.19062614466e-06 | 0.5625 | DCTN6 DCTN4 ACTR1A KLHL2 DCTN2 DCTN3 DCTN5 ACTR10 ACTR1B | actin cytoskeleton |
| REAC:R-HSA-199991 | 1.51539547009e-05 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 2.30925911408e-05 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Vesicle-mediated transport |
| REAC:R-HSA-2262752 | 9.11906842806e-05 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 9.81856437597e-05 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Cellular responses to stimuli |
| REAC:R-HSA-597592 | 0.000404992011324 | 0.5625 | DCTN6 DCTN4 ACTR1A KLHL2 DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Post-translational protein modification |
| GO:0005813 | 0.00168195932373 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR1B DCTN1 | centrosome |
| REAC:R-HSA-392499 | 0.00617373322543 | 0.5625 | DCTN6 DCTN4 ACTR1A KLHL2 DCTN2 DCTN3 DCTN5 ACTR10 DCTN1 | Metabolism of proteins |
| GO:0005815 | 0.00624847529737 | 0.5 | DCTN6 DCTN4 ACTR1A DCTN2 DCTN3 DCTN5 ACTR1B DCTN1 | microtubule organizing center |
| GO:0015630 | 0.0131881831989 | 0.5625 | DCTN6 DCTN4 DCTN2 ACTR1A DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | microtubule cytoskeleton |
| REAC:R-HSA-380259 | 0.0138109496979 | 0.1875 | DCTN3 DCTN2 ACTR1A | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0138109496979 | 0.1875 | DCTN3 DCTN2 ACTR1A | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.0157815219733 | 0.1875 | DCTN3 DCTN2 ACTR1A | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 0.0227774055368 | 0.1875 | DCTN3 DCTN2 ACTR1A | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.0227774055368 | 0.1875 | DCTN3 DCTN2 ACTR1A | Centrosome maturation |
| REAC:R-HSA-2565942 | 0.0274177485942 | 0.1875 | DCTN3 DCTN2 ACTR1A | Regulation of PLK1 Activity at G2/M Transition |
| GO:0005856 | 0.0329731009445 | 0.625 | DCTN6 DCTN4 ACTR1A KLHL2 DCTN2 DCTN3 DCTN5 ACTR10 ACTR1B DCTN1 | cytoskeleton |
| REAC:R-HSA-380320 | 0.0348930707744 | 0.1875 | DCTN3 DCTN2 ACTR1A | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-5620912 | 0.0384650037198 | 0.1875 | DCTN3 DCTN2 ACTR1A | Anchoring of the basal body to the plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| DCTN4 | DCTN5 | 1.0 | 0.508 |
| ACTR1B | DCTN5 | 1.0 | 0.15 |
| ACTR1B | DCTN4 | 1.0 | 0.172 |
| DCTN4 | DCTN6 | 1.0 | 0.32 |
| DCTN5 | DCTN3 | 1.0 | 0.73 |
| DCTN6 | DCTN5 | 1.0 | 0.638 |
| ACTR1B | ACTR10 | 1.0 | 0.096 |
| ACTR10 | ACTR1A | 1.0 | 0.47 |
| ACTR10 | DCTN5 | 1.0 | 0.3 |
| DCTN2 | ACTR1A | 1.0 | 0.854 |
| DCTN4 | ACTR10 | 1.0 | 0.898 |
| DCTN5 | ACTR1A | 1.0 | 0.518 |
| DCTN2 | DCTN4 | 1.0 | 0.628 |
| ACTR1A | DCTN1 | 1.0 | |
| ACTR1B | DCTN6 | 1.0 | 0.116 |
| DCTN6 | DCTN3 | 1.0 | 0.574 |
| DCTN2 | DCTN5 | 1.0 | 0.586 |
| DCTN2 | DCTN1 | 1.0 | |
| DCTN4 | DCTN1 | 1.0 | |
| DCTN4 | ACTR1A | 1.0 | 0.736 |
| ACTR1B | DCTN1 | 1.0 | |
| ACTR10 | DCTN6 | 1.0 | 0.182 |
| ACTR10 | DCTN3 | 1.0 | 0.726 |
| DCTN5 | DCTN1 | 1.0 | |
| DCTN4 | DCTN3 | 1.0 | 0.908 |
| DCTN3 | DCTN1 | 1.0 | |
| DCTN6 | ACTR1A | 1.0 | 0.268 |
| DCTN2 | ACTR1B | 1.0 | 0.348 |
| DCTN2 | ACTR10 | 1.0 | 0.434 |
| DCTN6 | DCTN1 | 0.999 | |
| ACTR1A | DCTN3 | 0.999 | 0.92 |
| ACTR10 | DCTN1 | 0.999 | |
| DCTN2 | DCTN3 | 0.999 | 0.912 |
| DCTN2 | DCTN6 | 0.999 | 0.452 |
| ACTR1B | ACTR1A | 0.999 | 0.274 |
| DCTN5 | PDGFD | 0.998 | |
| ACTR1B | DCTN3 | 0.998 | 0.262 |
| CPVL | DCTN5 | 0.998 | 0.024 |
| CPVL | ACTR1B | 0.998 | 0.05 |
| CPVL | DCTN6 | 0.997 | 0.074 |
| CPVL | DCTN2 | 0.995 | 0.128 |
| DCTN6 | PDGFD | 0.989 | |
| KLHL2 | TRIM8 | 0.988 | |
| KLHL2 | DCTN1 | 0.986 | |
| KLHL2 | ACTR10 | 0.985 | |
| KLHL2 | DCTN6 | 0.984 | |
| KLHL2 | ACTR1A | 0.983 | |
| KLHL2 | DCTN4 | 0.981 | |
| KLHL2 | DCTN2 | 0.977 | |
| KLHL2 | ACTR1B | 0.97 | |
| DCTN2 | DEFB127 | 0.969 | |
| DCTN6 | DEFB127 | 0.968 | |
| WNK3 | KLHL2 | 0.965 | |
| KLHL2 | DCTN3 | 0.964 | |
| KLHL2 | PIK3C2B | 0.964 | |
| KLHL2 | DCTN5 | 0.96 | |
| CPVL | ACTR10 | 0.957 | 0.06 |
| DCTN3 | PDGFD | 0.946 | |
| ACTR10 | DEFB127 | 0.946 | |
| ACTR1A | PDGFD | 0.924 | |
| KLHL2 | CPVL | 0.918 | |
| CPVL | DCTN4 | 0.912 | 0.036 |
| DEFB127 | ACTR1A | 0.91 | |
| DCTN2 | PDGFD | 0.894 | |
| DCTN4 | DEFB127 | 0.887 | |
| CPVL | ACTR1A | 0.88 | 0.068 |
| CPVL | DCTN1 | 0.877 | |
| DCTN4 | PDGFD | 0.863 | |
| PDGFD | DCTN1 | 0.855 | |
| ACTR10 | PDGFD | 0.819 | |
| ACTR1B | PDGFD | 0.794 | |
| DCTN5 | DEFB127 | 0.792 | |
| CPVL | DCTN3 | 0.779 | 0.028 |
| ACTR1B | DEFB127 | 0.704 | |
| DEFB127 | DCTN3 | 0.674 | |
| WNK3 | DCTN1 | 0.379 | |
| TRIM8 | CPVL | 0.369 | |
| WNK3 | TRIM8 | 0.333 | |
| WNK3 | DCTN4 | 0.327 | 0.066 |
| PIK3C2B | TRIM8 | 0.303 | |
| PIK3C2B | DCTN4 | 0.233 | 0.074 |
| WNK3 | ACTR1A | 0.22 | 0.118 |
| PIK3C2B | DCTN5 | 0.216 | 0.06 |
| WNK3 | ACTR1B | 0.214 | 0.066 |
| WNK3 | DCTN5 | 0.198 | 0.126 |
| WNK3 | DCTN3 | 0.194 | 0.098 |
| TRIM8 | ACTR1A | 0.187 | |
| TRIM8 | DCTN1 | 0.187 | |
| TRIM8 | ACTR1B | 0.187 | |
| TRIM8 | DCTN4 | 0.18 | |
| DEFB127 | DCTN1 | 0.171 | |
| PIK3C2B | ACTR1B | 0.169 | 0.038 |
| TRIM8 | DCTN3 | 0.168 | |
| TRIM8 | DCTN6 | 0.165 | |
| WNK3 | PIK3C2B | 0.164 | 0.104 |
| WNK3 | DCTN6 | 0.161 | 0.058 |
| TRIM8 | DCTN2 | 0.155 | |
| WNK3 | ACTR10 | 0.144 | 0.06 |
| TRIM8 | DCTN5 | 0.143 | |
| TRIM8 | ACTR10 | 0.143 | |
| PIK3C2B | ACTR10 | 0.095 | 0.0240571428571 |
| WNK3 | CPVL | 0.093 | 0.114 |
| WNK3 | DCTN2 | 0.092 | 0.094 |
| PIK3C2B | DCTN6 | 0.083 | 0.036 |
| PIK3C2B | DCTN3 | 0.083 | 0.068 |
| PIK3C2B | DCTN2 | 0.041 | 0.07 |
| CPVL | PDGFD | 0.036 | |
| PIK3C2B | CPVL | 0.03 | 0.178 |
| PIK3C2B | DCTN1 | 0.029 | |
| PIK3C2B | ACTR1A | 0.01 | 0.126 |
| CPVL | DEFB127 | 0.003 |
Related Complexes