hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09956.1
Complex Portal: CPX-13830
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFGE8 | Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] | 5 | UniProt NCBI |
| CACNA2D1 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] | 5 | UniProt NCBI |
| IDUA | Alpha-L-iduronidase (EC 3.2.1.76) | 5 | UniProt NCBI |
| ITGB5 | Integrin beta-5 | 5 | UniProt NCBI |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | 5 | UniProt NCBI |
| LAMB3 | Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta) | 5 | UniProt NCBI |
| TOR3A | Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) | 5 | UniProt NCBI |
| ITGAV | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2347 | 2.39226645298e-05 | 0.25 | ITGB5 ITGAV | ITGAV-ITGB5-SPP1 complex |
| CORUM:2350 | 2.39226645298e-05 | 0.25 | ITGB5 ITGAV | ITGAV-ITGB5 complex |
| CORUM:2343 | 7.17483486175e-05 | 0.25 | ITGB5 ITGAV | ITGAV-ITGB5-PLAUR complex |
| CORUM:2345 | 7.17483486175e-05 | 0.25 | ITGB5 ITGAV | ITGAV-ITGB5-ICAM4 complex |
| CORUM:2346 | 7.17483486175e-05 | 0.25 | ITGB5 ITGAV | ITGAV-ITGB5-ADAM9 complex |
| CORUM:3117 | 7.17483486175e-05 | 0.25 | ITGB5 ITGAV | ITGB5-ITGAV-VTN complex |
| CORUM:2348 | 7.17483486175e-05 | 0.25 | ITGB5 ITGAV | ITGAV-ITGB5-CYR61 complex |
| KEGG:04512 | 0.000251141708404 | 0.375 | LAMB3 ITGB5 ITGAV | ECM-receptor interaction |
| KEGG:05412 | 0.000262665274355 | 0.375 | CACNA2D1 ITGB5 ITGAV | Arrhythmogenic right ventricular cardiomyopathy |
| WP:WP2118 | 0.000314757575276 | 0.375 | CACNA2D1 ITGB5 ITGAV | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05410 | 0.000367694824708 | 0.375 | CACNA2D1 ITGB5 ITGAV | Hypertrophic cardiomyopathy |
| KEGG:05414 | 0.000367694824708 | 0.375 | CACNA2D1 ITGB5 ITGAV | Dilated cardiomyopathy |
| REAC:R-HSA-3000171 | 0.000391615111842 | 0.375 | LAMB3 ITGB5 ITGAV | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-1236973 | 0.00116989543065 | 0.25 | ITGB5 ITGAV | Cross-presentation of particulate exogenous antigens (phagosomes) |
| KEGG:04148 | 0.00160212912447 | 0.375 | ITGAV MFGE8 ITGB5 | Efferocytosis |
| KEGG:04510 | 0.00432603102979 | 0.375 | LAMB3 ITGB5 ITGAV | Focal adhesion |
| WP:WP306 | 0.00797315937972 | 0.375 | LAMB3 ITGB5 ITGAV | Focal adhesion |
| REAC:R-HSA-3000170 | 0.0128161014463 | 0.25 | ITGB5 ITGAV | Syndecan interactions |
| GO:0034684 | 0.0131096201623 | 0.25 | ITGB5 ITGAV | integrin alphav-beta5 complex |
| KEGG:04151 | 0.0191136955138 | 0.375 | LAMB3 ITGB5 ITGAV | PI3K-Akt signaling pathway |
| REAC:R-HSA-3000157 | 0.0194471683576 | 0.25 | LAMB3 ITGAV | Laminin interactions |
| KEGG:05165 | 0.0207258251199 | 0.375 | LAMB3 ITGB5 ITGAV | Human papillomavirus infection |
| REAC:R-HSA-2129379 | 0.0224821270291 | 0.25 | ITGB5 ITGAV | Molecules associated with elastic fibres |
| WP:WP3932 | 0.0231589023106 | 0.375 | LAMB3 ITGB5 ITGAV | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP4172 | 0.0300698308207 | 0.375 | LAMB3 ITGB5 ITGAV | PI3K Akt signaling pathway |
| REAC:R-HSA-1566948 | 0.0348192347107 | 0.25 | ITGB5 ITGAV | Elastic fibre formation |
| GO:0035987 | 0.0349415747767 | 0.375 | LAMB3 ITGB5 ITGAV | endodermal cell differentiation |
| REAC:R-HSA-1474244 | 0.0421371538836 | 0.375 | LAMB3 ITGB5 ITGAV | Extracellular matrix organization |
| REAC:R-HSA-2173789 | 0.0452582424141 | 0.25 | ITGB5 ITGAV | TGF-beta receptor signaling activates SMADs |
| KEGG:05222 | 0.0463619704146 | 0.25 | LAMB3 ITGAV | Small cell lung cancer |
| CORUM:2352 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB6-SPP1 complex |
| CORUM:2353 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB6-TGFB3 complex |
| CORUM:2354 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB6 complex |
| CORUM:2365 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB3-COL4A3 complex |
| CORUM:2373 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB3-SPP1 complex |
| CORUM:2816 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB3 complex |
| CORUM:2846 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB3-THBS1 complex |
| CORUM:2849 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB3-NOV complex |
| CORUM:2358 | 0.0499436884912 | 0.125 | ITGAV | ITGAV-ITGB3-SPP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MFGE8 | ITGB5 | 0.992 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ITGAV | MFGE8 | 0.986 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LAMB3 | TOR3A | 0.978 | 0.02 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CACNA2D1 | ITGAV | 0.973 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PCSK9 | TOR3A | 0.968 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ITGAV | TOR3A | 0.966 | 0.022 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IDUA | TOR3A | 0.965 | 0.062 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ITGAV | ITGB5 | 0.963 | 0.236 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| MFGE8 | TOR3A | 0.959 | 0.058 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ITGB5 | TOR3A | 0.954 | 0.124 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CACNA2D1 | MFGE8 | 0.87 | 0.256 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGAV | IDUA | 0.65 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGB5 | IDUA | 0.604 | 0.208 | bioplex3_WMM WMM_only | |
| MFGE8 | IDUA | 0.575 | 0.196 | bioplex3_WMM WMM_only | |
| LAMB3 | MFGE8 | 0.473 | 0.156 | bioplex3_WMM WMM_only | |
| LAMB3 | IDUA | 0.473 | 0.116 | bioplex3_WMM WMM_only | |
| PCSK9 | MFGE8 | 0.454 | 0.2461875 | bioplex3_WMM WMM_only | |
| LAMB3 | ITGAV | 0.454 | 0.148 | bioplex3_WMM WMM_only | |
| PCSK9 | IDUA | 0.454 | 0.106 | bioplex3_WMM WMM_only | |
| LAMB3 | ITGB5 | 0.454 | 0.152 | bioplex3_WMM WMM_only | |
| PCSK9 | ITGB5 | 0.443 | 0.148 | bioplex3_WMM WMM_only | |
| LAMB3 | PCSK9 | 0.443 | 0.12 | bioplex3_WMM WMM_only | |
| PCSK9 | ITGAV | 0.443 | 0.178 | bioplex3_WMM WMM_only | |
| CACNA2D1 | IDUA | 0.171 | 0.12 | bioplex3_WMM WMM_only | |
| CACNA2D1 | ITGB5 | 0.151 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| CACNA2D1 | TOR3A | 0.135 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| LAMB3 | CACNA2D1 | 0.054 | 0.096 | bioplex3_WMM WMM_only | |
| PCSK9 | CACNA2D1 | 0.04 | 0.122 | bioplex3_WMM WMM_only |
Related Complexes