hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09957.1
Complex Portal: CPX-16523
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | 5 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | 5 | UniProt NCBI |
| EIF4ENIF1 | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | 5 | UniProt NCBI |
| EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 9.94862495294e-15 | 0.777777777778 | EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | Translation factors |
| GO:0016281 | 5.32373836614e-13 | 0.666666666667 | EIF4E1B EIF4E EIF4A1 EIF4G1 EIF4A2 EIF4G3 | eukaryotic translation initiation factor 4F complex |
| GO:0034518 | 2.48309898437e-12 | 0.666666666667 | EIF4E1B EIF4E EIF4A1 EIF4G1 EIF4A2 EIF4G3 | RNA cap binding complex |
| WP:WP4566 | 2.53302558407e-12 | 0.666666666667 | EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0045182 | 3.55584224151e-12 | 0.888888888889 | EIF4E1B EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | translation regulator activity |
| GO:0006413 | 1.43485453193e-09 | 0.777777777778 | EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | translational initiation |
| GO:0003743 | 2.17807545594e-09 | 0.666666666667 | EIF4E1B EIF4E EIF4A1 EIF4G1 EIF4A2 EIF4G3 | translation initiation factor activity |
| REAC:R-HSA-72662 | 2.8999951733e-08 | 0.555555555556 | EIF4E EIF4G1 EIF4A1 EIF4EBP1 EIF4A2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0008135 | 4.02706673296e-08 | 0.666666666667 | EIF4E1B EIF4E EIF4A1 EIF4G1 EIF4A2 EIF4G3 | translation factor activity, RNA binding |
| REAC:R-HSA-1169408 | 4.738886091e-08 | 0.555555555556 | EIF4E EIF4G1 EIF4A2 EIF4A1 EIF4G3 | ISG15 antiviral mechanism |
| CORUM:5253 | 5.24129669272e-08 | 0.333333333333 | EIF4G1 EIF4A1 EIF4E | MNK1-eIF4F complex |
| REAC:R-HSA-1169410 | 7.40895733361e-08 | 0.555555555556 | EIF4E EIF4G1 EIF4A2 EIF4A1 EIF4G3 | Antiviral mechanism by IFN-stimulated genes |
| GO:0090079 | 1.33972143912e-07 | 0.666666666667 | EIF4E1B EIF4E EIF4A1 EIF4G1 EIF4A2 EIF4G3 | translation regulator activity, nucleic acid binding |
| REAC:R-HSA-429947 | 1.66051543107e-07 | 0.444444444444 | EIF4E EIF4G1 EIF4A1 EIF4A2 | Deadenylation of mRNA |
| REAC:R-HSA-72613 | 9.1676686367e-07 | 0.555555555556 | EIF4E EIF4G1 EIF4A1 EIF4EBP1 EIF4A2 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 9.1676686367e-07 | 0.555555555556 | EIF4E EIF4G1 EIF4A1 EIF4EBP1 EIF4A2 | Cap-dependent Translation Initiation |
| GO:0006417 | 1.09600590834e-06 | 0.777777777778 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4G3 EIF4G1 EIF4A2 | regulation of translation |
| GO:0006412 | 1.35517561568e-06 | 0.888888888889 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | translation |
| GO:0043043 | 1.7156017252e-06 | 0.888888888889 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | peptide biosynthetic process |
| GO:0034248 | 3.50875015931e-06 | 0.777777777778 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4G3 EIF4G1 EIF4A2 | regulation of amide metabolic process |
| REAC:R-HSA-429914 | 5.28451792598e-06 | 0.444444444444 | EIF4E EIF4G1 EIF4A1 EIF4A2 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-913531 | 6.67725488184e-06 | 0.555555555556 | EIF4E EIF4G1 EIF4A2 EIF4A1 EIF4G3 | Interferon Signaling |
| REAC:R-HSA-72649 | 7.04426707928e-06 | 0.444444444444 | EIF4E EIF4G1 EIF4A1 EIF4A2 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 7.04426707928e-06 | 0.444444444444 | EIF4E EIF4G1 EIF4A1 EIF4A2 | Ribosomal scanning and start codon recognition |
| GO:0043604 | 7.0902170011e-06 | 0.888888888889 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | amide biosynthetic process |
| GO:0006518 | 7.90297621146e-06 | 0.888888888889 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | peptide metabolic process |
| GO:0000339 | 1.01062722265e-05 | 0.444444444444 | EIF4E EIF4E1B EIF4A1 EIF4G3 | RNA cap binding |
| GO:0006446 | 1.45506131641e-05 | 0.555555555556 | EIF4EBP2 EIF4G1 EIF4G3 EIF4EBP1 EIF4A2 | regulation of translational initiation |
| GO:0010608 | 1.7173000564e-05 | 0.777777777778 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4G3 EIF4G1 EIF4A2 | post-transcriptional regulation of gene expression |
| WP:WP4549 | 3.39261721721e-05 | 0.444444444444 | EIF4EBP2 EIF4G1 EIF4A1 EIF4E | Fragile X syndrome |
| GO:0031369 | 5.78196693602e-05 | 0.444444444444 | EIF4E EIF4G1 EIF4EBP2 EIF4EBP1 | translation initiation factor binding |
| GO:0043603 | 7.3411791618e-05 | 0.888888888889 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | amide metabolic process |
| REAC:R-HSA-166208 | 7.6950453904e-05 | 0.333333333333 | EIF4E EIF4G1 EIF4EBP1 | mTORC1-mediated signalling |
| REAC:R-HSA-72766 | 8.03363746558e-05 | 0.555555555556 | EIF4E EIF4G1 EIF4A1 EIF4EBP1 EIF4A2 | Translation |
| REAC:R-HSA-156827 | 8.811157512e-05 | 0.444444444444 | EIF4E EIF4G1 EIF4A1 EIF4A2 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 9.13803206472e-05 | 0.444444444444 | EIF4E EIF4G1 EIF4A1 EIF4A2 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| WP:WP585 | 0.000302323309878 | 0.333333333333 | EIF4EBP1 EIF4A1 EIF4E | Interferon type I signaling pathways |
| REAC:R-HSA-165159 | 0.000403163829071 | 0.333333333333 | EIF4E EIF4G1 EIF4EBP1 | MTOR signalling |
| GO:0008190 | 0.00045145282213 | 0.333333333333 | EIF4G1 EIF4EBP2 EIF4EBP1 | eukaryotic initiation factor 4E binding |
| KEGG:01521 | 0.000517754441228 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 0.000679986209508 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | Longevity regulating pathway |
| KEGG:04066 | 0.00124312860357 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | HIF-1 signaling pathway |
| GO:1901566 | 0.00142628999788 | 0.888888888889 | EIF4ENIF1 EIF4EBP2 EIF4E EIF4EBP1 EIF4A1 EIF4G1 EIF4A2 EIF4G3 | organonitrogen compound biosynthetic process |
| KEGG:04910 | 0.00255835080133 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | Insulin signaling pathway |
| REAC:R-HSA-1280215 | 0.00320985436052 | 0.555555555556 | EIF4E EIF4G1 EIF4A2 EIF4A1 EIF4G3 | Cytokine Signaling in Immune system |
| KEGG:04150 | 0.00413269570012 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | mTOR signaling pathway |
| WP:WP516 | 0.00468193988771 | 0.222222222222 | EIF4EBP1 EIF4E | Hypertrophy model |
| WP:WP3879 | 0.00642003616322 | 0.222222222222 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| WP:WP5115 | 0.0114539669178 | 0.333333333333 | EIF4EBP1 EIF4A2 EIF4E | Network map of SARS CoV 2 signaling pathway |
| GO:0003729 | 0.013473555316 | 0.555555555556 | EIF4E EIF4G1 EIF4ENIF1 EIF4A1 EIF4G3 | mRNA binding |
| GO:0017148 | 0.0142653929889 | 0.444444444444 | EIF4G1 EIF4ENIF1 EIF4EBP2 EIF4EBP1 | negative regulation of translation |
| KEGG:05416 | 0.0239862693019 | 0.222222222222 | EIF4G1 EIF4G3 | Viral myocarditis |
| GO:0034249 | 0.0272753050284 | 0.444444444444 | EIF4G1 EIF4ENIF1 EIF4EBP2 EIF4EBP1 | negative regulation of amide metabolic process |
| KEGG:04151 | 0.0288560061328 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | PI3K-Akt signaling pathway |
| WP:WP3932 | 0.0343032557242 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP4172 | 0.0444870284412 | 0.333333333333 | EIF4EBP1 EIF4E1B EIF4E | PI3K Akt signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4E | EIF4ENIF1 | 0.999 | 0.2115 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF4E | EIF4G3 | 0.999 | 0.21 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EIF4E | EIF4EBP2 | 0.998 | 0.124 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 |
mutually_exclusive (A6NMX2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM | |
| EIF4E | EIF4G1 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| EIF4G1 | EIF4A1 | 0.993 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| EIF4A1 | EIF4G3 | 0.986 | 0.152 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| EIF4E1B | EIF4E | 0.982 |
mutually_exclusive (Q13541)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4EBP2 | 0.982 | 0.042 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4EBP1 | 0.977 |
mutually_exclusive (P06730)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4E | EIF4A1 | 0.963 | 0.426 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF4G1 | EIF4A2 | 0.934 |
structurally_consistent (dimer)
|
youn () bioplex_WMM bioplex3_WMM fraction treiber_WMM | |
| EIF4EBP1 | EIF4G3 | 0.908 | 0.148 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E1B | EIF4EBP2 | 0.904 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4EBP2 | 0.902 | 0.03 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4G3 | EIF4ENIF1 | 0.885 | 0.138 |
mutually_exclusive (P06730)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| EIF4EBP2 | EIF4ENIF1 | 0.834 | 0.178 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4A2 | 0.791 |
structurally_consistent (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4G1 | EIF4G3 | 0.786 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| EIF4A2 | EIF4G3 | 0.773 | 0.068 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EIF4G1 | EIF4EBP2 | 0.756 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| EIF4E | EIF4A2 | 0.689 | 0.16 |
structurally_consistent (dimer)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| EIF4E1B | EIF4G3 | 0.675 | bioplex3_WMM WMM_only | ||
| EIF4A2 | EIF4EBP2 | 0.656 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| EIF4EBP1 | EIF4ENIF1 | 0.588 | 0.056 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| EIF4G1 | EIF4ENIF1 | 0.581 |
mutually_exclusive (P06730)
|
youn () bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| EIF4E1B | EIF4ENIF1 | 0.388 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4EBP1 | EIF4A2 | 0.297 | 0.048 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4E1B | EIF4G1 | 0.245 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4EBP1 | EIF4G1 | 0.188 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| EIF4A2 | EIF4ENIF1 | 0.119 | 0.088 | youn () bioplex3_WMM youn_WMM WMM_only | |
| EIF4A1 | EIF4EBP2 | 0.074 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| EIF4E1B | EIF4A1 | 0.01 |
structurally_consistent (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4EBP1 | EIF4A1 | 0.003 | 0.114 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4A1 | EIF4ENIF1 | 0.002 | 0.068 | youn () bioplex3_WMM youn_WMM WMM_only |
Related Complexes