hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09961.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FADD | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) | 5 | UniProt NCBI |
| CASP8 | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | 5 | UniProt NCBI |
| CFLAR | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] | 5 | UniProt NCBI |
| SDS | L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) | 5 | UniProt NCBI |
| NTF4 | Neurotrophin-4 (NT-4) (Neurotrophin-5) (NT-5) (Neutrophic factor 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5798 | 7.01606139244e-10 | 0.75 | FADD CASP8 CFLAR | Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced |
| CORUM:5799 | 7.01606139244e-10 | 0.75 | FADD CASP8 CFLAR | DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced |
| REAC:R-HSA-75158 | 4.91023464396e-08 | 0.75 | FADD CASP8 CFLAR | TRAIL signaling |
| WP:WP2507 | 3.38413923581e-07 | 0.75 | FADD CASP8 CFLAR | Nanomaterial induced apoptosis |
| WP:WP314 | 2.94331624137e-06 | 0.75 | FADD CASP8 CFLAR | Fas ligand pathway and stress induction of heat shock proteins |
| GO:0097342 | 3.84440695359e-06 | 0.75 | FADD CASP8 CFLAR | ripoptosome |
| CORUM:5473 | 5.12628525639e-06 | 0.5 | FADD CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5860 | 5.12628525639e-06 | 0.5 | FADD CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5991 | 5.12628525639e-06 | 0.5 | FADD CASP8 | LRRK2-FADD-CASP8 complex |
| CORUM:5808 | 5.12628525639e-06 | 0.5 | FADD CASP8 | DISC complex (CD95, FADD, CASP8) |
| CORUM:5800 | 5.12628525639e-06 | 0.5 | FADD CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5859 | 5.12628525639e-06 | 0.5 | FADD CASP8 | FAS-FADD-CASP8-CASP10 complex |
| GO:0031264 | 1.34540429244e-05 | 0.75 | FADD CASP8 CFLAR | death-inducing signaling complex |
| CORUM:6414 | 1.53774525569e-05 | 0.5 | FADD CASP8 | RIPK1-FADD-caspase-8 complex |
| CORUM:5749 | 1.53774525569e-05 | 0.5 | CFLAR CASP8 | MRIT complex |
| WP:WP254 | 2.16610999348e-05 | 0.75 | FADD CASP8 CFLAR | Apoptosis |
| WP:WP1772 | 2.64882854506e-05 | 0.75 | FADD CASP8 CFLAR | Apoptosis modulation and signaling |
| CORUM:2054 | 3.07520988333e-05 | 0.5 | FADD CASP8 | CASP8-FADD-MALT1-BCL10 complex |
| WP:WP231 | 3.31659065747e-05 | 0.75 | FADD CASP8 CFLAR | TNF alpha signaling pathway |
| KEGG:05142 | 3.7506465024e-05 | 0.75 | FADD CASP8 CFLAR | Chagas disease |
| KEGG:04668 | 4.7291535364e-05 | 0.75 | FADD CASP8 CFLAR | TNF signaling pathway |
| REAC:R-HSA-75157 | 6.15041976665e-05 | 0.5 | FADD CASP8 | FasL/ CD95L signaling |
| KEGG:04210 | 9.58294361569e-05 | 0.75 | FADD CASP8 CFLAR | Apoptosis |
| KEGG:05160 | 0.000124866609719 | 0.75 | FADD CASP8 CFLAR | Hepatitis C |
| KEGG:04217 | 0.000142922483011 | 0.75 | FADD CASP8 CFLAR | Necroptosis |
| REAC:R-HSA-9693928 | 0.000153732433522 | 0.5 | FADD CASP8 | Defective RIPK1-mediated regulated necrosis |
| REAC:R-HSA-9013957 | 0.000153732433522 | 0.5 | FADD CASP8 | TLR3-mediated TICAM1-dependent programmed cell death |
| WP:WP2513 | 0.000168398502686 | 0.5 | FADD CASP8 | Nanoparticle triggered regulated necrosis |
| REAC:R-HSA-2562578 | 0.000215205765992 | 0.5 | FADD CASP8 | TRIF-mediated programmed cell death |
| WP:WP5182 | 0.000232143427839 | 0.5 | FADD CASP8 | Pro survival signaling of neuroprotectin D1 |
| WP:WP384 | 0.000346844620397 | 0.5 | FADD CASP8 | Apoptosis modulation by HSP70 |
| REAC:R-HSA-69416 | 0.000461028962628 | 0.5 | FADD CASP8 | Dimerization of procaspase-8 |
| REAC:R-HSA-3371378 | 0.000461028962628 | 0.5 | FADD CASP8 | Regulation by c-FLIP |
| REAC:R-HSA-5218900 | 0.000461028962628 | 0.5 | FADD CASP8 | CASP8 activity is inhibited |
| REAC:R-HSA-73887 | 0.000464818544718 | 0.75 | FADD CASP8 CFLAR | Death Receptor Signaling |
| WP:WP4864 | 0.000484429625977 | 0.5 | FADD CASP8 | Host pathogen interaction of human coronaviruses apoptosis |
| REAC:R-HSA-933543 | 0.000563428413222 | 0.5 | FADD CASP8 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| REAC:R-HSA-140534 | 0.000798898068561 | 0.5 | FADD CASP8 | Caspase activation via Death Receptors in the presence of ligand |
| KEGG:04215 | 0.00101582950709 | 0.5 | FADD CASP8 | Apoptosis - multiple species |
| GO:0070266 | 0.00140301566648 | 0.75 | FADD CASP8 CFLAR | necroptotic process |
| WP:WP2036 | 0.00160392090455 | 0.5 | FADD CASP8 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-5357769 | 0.00175047124894 | 0.5 | FADD CASP8 | Caspase activation via extrinsic apoptotic signalling pathway |
| GO:0097300 | 0.0025122894873 | 0.75 | FADD CASP8 CFLAR | programmed necrotic cell death |
| GO:0035877 | 0.0028092043205 | 0.5 | FADD CASP8 | death effector domain binding |
| REAC:R-HSA-5357786 | 0.00282403231951 | 0.5 | FADD CASP8 | TNFR1-induced proapoptotic signaling |
| WP:WP5039 | 0.00337093843289 | 0.5 | FADD CASP8 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| WP:WP4754 | 0.0035028118218 | 0.5 | CFLAR CASP8 | IL 18 signaling pathway |
| WP:WP3865 | 0.00363720277712 | 0.5 | FADD CASP8 | Novel intracellular components of RIG I like receptor pathway |
| REAC:R-HSA-5213460 | 0.00444848198459 | 0.5 | FADD CASP8 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.00444848198459 | 0.5 | FADD CASP8 | Regulation of necroptotic cell death |
| KEGG:04622 | 0.00518715200321 | 0.5 | FADD CASP8 | RIG-I-like receptor signaling pathway |
| WP:WP4655 | 0.00528146385782 | 0.5 | FADD CASP8 | Cytosolic DNA sensing pathway |
| KEGG:04623 | 0.00601982850302 | 0.5 | FADD CASP8 | Cytosolic DNA-sensing pathway |
| KEGG:01524 | 0.00601982850302 | 0.5 | FADD CASP8 | Platinum drug resistance |
| WP:WP4674 | 0.00612927993034 | 0.5 | FADD CASP8 | Head and neck squamous cell carcinoma |
| KEGG:04657 | 0.00728891894502 | 0.5 | FADD CASP8 | IL-17 signaling pathway |
| WP:WP75 | 0.00862655865142 | 0.5 | FADD CASP8 | Toll like receptor signaling pathway |
| KEGG:04620 | 0.00931062778609 | 0.5 | FADD CASP8 | Toll-like receptor signaling pathway |
| GO:0008625 | 0.00951168180783 | 0.75 | FADD CASP8 CFLAR | extrinsic apoptotic signaling pathway via death domain receptors |
| REAC:R-HSA-5357905 | 0.00966180252737 | 0.5 | FADD CASP8 | Regulation of TNFR1 signaling |
| REAC:R-HSA-5218859 | 0.0140623832262 | 0.5 | FADD CASP8 | Regulated Necrosis |
| REAC:R-HSA-75893 | 0.0140623832262 | 0.5 | FADD CASP8 | TNF signaling |
| GO:0031265 | 0.0168521501606 | 0.5 | FADD CASP8 | CD95 death-inducing signaling complex |
| KEGG:05162 | 0.0189154103852 | 0.5 | FADD CASP8 | Measles |
| KEGG:04936 | 0.0189154103852 | 0.5 | FADD CASP8 | Alcoholic liver disease |
| WP:WP4630 | 0.01895043011 | 0.5 | FADD CASP8 | Measles virus infection |
| WP:WP4666 | 0.023499356813 | 0.5 | FADD CASP8 | Hepatitis B infection |
| CORUM:1062 | 0.0249718442456 | 0.25 | CASP8 | BAR-BCL2-CASP8 complex |
| CORUM:5861 | 0.0249718442456 | 0.25 | FADD | FAS-FADD-CASP10 complex |
| KEGG:05164 | 0.0254912281659 | 0.5 | FADD CASP8 | Influenza A |
| KEGG:05152 | 0.02620193588 | 0.5 | FADD CASP8 | Tuberculosis |
| KEGG:04621 | 0.02620193588 | 0.5 | FADD CASP8 | NOD-like receptor signaling pathway |
| KEGG:05161 | 0.0269222811984 | 0.5 | FADD CASP8 | Hepatitis B |
| REAC:R-HSA-168928 | 0.0282617295192 | 0.5 | FADD CASP8 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:05130 | 0.0334335704012 | 0.5 | FADD CASP8 | Pathogenic Escherichia coli infection |
| KEGG:05167 | 0.0346546128597 | 0.5 | FADD CASP8 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05169 | 0.0397541089323 | 0.5 | FADD CASP8 | Epstein-Barr virus infection |
| REAC:R-HSA-168164 | 0.041644107744 | 0.5 | FADD CASP8 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-9645723 | 0.041644107744 | 0.5 | FADD CASP8 | Diseases of programmed cell death |
| REAC:R-HSA-166166 | 0.0434971593242 | 0.5 | FADD CASP8 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.0434971593242 | 0.5 | FADD CASP8 | TRIF(TICAM1)-mediated TLR4 signaling |
| KEGG:05163 | 0.0451972531521 | 0.5 | FADD CASP8 | Human cytomegalovirus infection |
| KEGG:05170 | 0.0456663239038 | 0.5 | FADD CASP8 | Human immunodeficiency virus 1 infection |
| KEGG:00290 | 0.0488584186592 | 0.25 | SDS | Valine, leucine and isoleucine biosynthesis |
| CORUM:6175 | 0.049938562206 | 0.25 | FADD | Caspase-10-SUMO-FADD/Drp1 complex |
| CORUM:5856 | 0.049938562206 | 0.25 | FADD | AK2-FADD-caspase-10 (AFAC10) complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FADD | CASP8 | 0.997 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CASP8 | CFLAR | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FADD | NTF4 | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SDS | FADD | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes