hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09969.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CYP2C9 | Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| TOMM40 | Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) | 5 | UniProt NCBI |
| CYP2C8 | Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| CYP2C19 | Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| CYP2C18 | Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2491 | 6.79584193643e-06 | 0.666666666667 | CYP2C19 CYP2C18 | Diclofenac metabolic pathway |
| WP:WP43 | 0.000973512535349 | 0.666666666667 | CYP2C19 CYP2C18 | Oxidation by cytochrome P450 |
| KEGG:05204 | 0.00104947736992 | 0.666666666667 | CYP2C19 CYP2C18 | Chemical carcinogenesis - DNA adducts |
| REAC:R-HSA-211981 | 0.00143063482691 | 0.666666666667 | CYP2C19 CYP2C18 | Xenobiotics |
| KEGG:04726 | 0.00265115528622 | 0.666666666667 | CYP2C19 CYP2C18 | Serotonergic synapse |
| REAC:R-HSA-211897 | 0.00673703034894 | 0.666666666667 | CYP2C19 CYP2C18 | Cytochrome P450 - arranged by substrate type |
| WP:WP702 | 0.0101834993772 | 0.666666666667 | CYP2C19 CYP2C18 | Metapathway biotransformation Phase I and II |
| REAC:R-HSA-211945 | 0.019882541548 | 0.666666666667 | CYP2C19 CYP2C18 | Phase I - Functionalization of compounds |
| WP:WP4720 | 0.0496447587094 | 0.333333333333 | CYP2C18 | Eicosanoid metabolism via cytochrome P450 monooxygenases pathway |
| CORUM:3092 | 0.0499402709677 | 0.333333333333 | TOMM40 | APP-TOM40 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CYP2C9 | CYP2C18 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2C9 | CYP2C19 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2C8 | CYP2C18 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CYP2C9 | TOMM40 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2C19 | CYP2C18 | 0.985 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CYP2C9 | CYP2C8 | 0.902 | bioplex3_WMM WMM_only | |
| CYP2C19 | TOMM40 | 0.273 | bioplex_WMM bioplex3_WMM WMM_only | |
| CYP2C18 | TOMM40 | 0.243 | bioplex_WMM bioplex3_WMM WMM_only | |
| CYP2C8 | TOMM40 | 0.006 | youn_WMM WMM_only |
Related Complexes