hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09978.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
BIRC2	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	5	UniProt NCBI
CXCL1	Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]	5	UniProt NCBI
HTRA2	Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)	5	UniProt NCBI
NFIC	Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)	5	UniProt NCBI
CXCL3	C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]	5	UniProt NCBI
BIRC3	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)	5	UniProt NCBI
DIABLO	Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]	5	UniProt NCBI
TANK	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	5	UniProt NCBI
TRAF2	TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)	5	UniProt NCBI
TRAF1	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)	5	UniProt NCBI
IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP231	6.10075928061e-10	0.6	TANK TRAF2 BIRC3 TRAF1 DIABLO BIRC2	TNF alpha signaling pathway
KEGG:04210	2.78091592761e-09	0.6	DIABLO TRAF2 HTRA2 BIRC3 TRAF1 BIRC2	Apoptosis
KEGG:04621	9.17263048828e-09	0.6	TANK IKBKE TRAF2 BIRC3 CXCL1 BIRC2	NOD-like receptor signaling pathway
REAC:R-HSA-5357905	1.17728545642e-08	0.5	BIRC3 IKBKE TRAF1 BIRC2 TRAF2	Regulation of TNFR1 signaling
REAC:R-HSA-75893	3.10288498637e-08	0.5	BIRC3 IKBKE TRAF1 BIRC2 TRAF2	TNF signaling
KEGG:04064	5.37690461794e-08	0.5	CXCL1 TRAF1 BIRC2 TRAF2 BIRC3	NF-kappa B signaling pathway
WP:WP254	6.58010695697e-08	0.5	BIRC3 TRAF1 BIRC2 TRAF2 DIABLO	Apoptosis
KEGG:04668	1.29036955539e-07	0.5	CXCL1 TRAF1 BIRC2 TRAF2 BIRC3	TNF signaling pathway
KEGG:04215	1.31083166186e-07	0.4	BIRC3 DIABLO BIRC2 HTRA2	Apoptosis - multiple species
REAC:R-HSA-5357786	2.8179151173e-07	0.4	BIRC3 IKBKE BIRC2 TRAF2	TNFR1-induced proapoptotic signaling
REAC:R-HSA-168164	4.9739671933e-07	0.5	BIRC3 IKBKE BIRC2 TRAF2 TANK	Toll Like Receptor 3 (TLR3) Cascade
REAC:R-HSA-937061	5.55549716703e-07	0.5	BIRC3 IKBKE BIRC2 TRAF2 TANK	TRIF(TICAM1)-mediated TLR4 signaling
REAC:R-HSA-166166	5.55549716703e-07	0.5	BIRC3 IKBKE BIRC2 TRAF2 TANK	MyD88-independent TLR4 cascade
WP:WP2036	6.34019510892e-07	0.4	BIRC3 TRAF1 BIRC2 TRAF2	TNF related weak inducer of apoptosis TWEAK signaling pathway
REAC:R-HSA-5357956	9.51119385451e-07	0.4	BIRC3 TRAF1 BIRC2 TRAF2	TNFR1-induced NF-kappa-B signaling pathway
GO:0071345	1.16809645239e-06	0.8	IKBKE TANK TRAF2 HTRA2 BIRC3 TRAF1 CXCL1 BIRC2	cellular response to cytokine stimulus
GO:0035631	1.81927560642e-06	0.4	DIABLO BIRC2 TRAF2 HTRA2	CD40 receptor complex
REAC:R-HSA-166016	2.28992459356e-06	0.5	BIRC3 IKBKE BIRC2 TRAF2 TANK	Toll Like Receptor 4 (TLR4) Cascade
REAC:R-HSA-73887	2.69125735642e-06	0.5	BIRC3 IKBKE TRAF1 BIRC2 TRAF2	Death Receptor Signaling
GO:0034097	2.9986604368e-06	0.8	IKBKE TANK TRAF2 HTRA2 BIRC3 TRAF1 CXCL1 BIRC2	response to cytokine
REAC:R-HSA-168898	4.72283997553e-06	0.5	BIRC3 IKBKE BIRC2 TRAF2 TANK	Toll-like Receptor Cascades
REAC:R-HSA-5676594	9.16769422079e-06	0.3	BIRC3 BIRC2 TRAF2	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
KEGG:05222	1.15020714318e-05	0.4	BIRC3 TRAF1 BIRC2 TRAF2	Small cell lung cancer
WP:WP1772	1.51423209535e-05	0.4	BIRC3 DIABLO BIRC2 HTRA2	Apoptosis modulation and signaling
GO:0019221	1.59042523128e-05	0.7	TANK TRAF2 IKBKE BIRC3 TRAF1 CXCL1 BIRC2	cytokine-mediated signaling pathway
WP:WP4658	2.5825431588e-05	0.4	BIRC3 TRAF1 BIRC2 TRAF2	Small cell lung cancer
CORUM:5529	3.07577115383e-05	0.2	BIRC2 TRAF2	TRAF2-cIAP1/BIRC2 complex
GO:0043122	8.93403909543e-05	0.6	TANK IKBKE TRAF2 BIRC3 TRAF1 BIRC2	regulation of canonical NF-kappaB signal transduction
CORUM:5531	9.22394575203e-05	0.2	BIRC2 TRAF2	Tumor necrosis factor receptor 1 signaling complex
CORUM:5210	9.22394575203e-05	0.2	TANK TRAF2	TANK-TRAF2-TRAF3 complex
GO:0007249	0.000165538747619	0.6	TANK IKBKE TRAF2 BIRC3 TRAF1 BIRC2	canonical NF-kappaB signal transduction
REAC:R-HSA-933541	0.000201713088963	0.3	TANK TRAF2 IKBKE	TRAF6 mediated IRF7 activation
KEGG:05417	0.000222091335709	0.4	CXCL1 IKBKE TRAF2 TANK	Lipid and atherosclerosis
REAC:R-HSA-5213460	0.000224045063065	0.3	BIRC3 BIRC2 TRAF2	RIPK1-mediated regulated necrosis
REAC:R-HSA-5675482	0.000224045063065	0.3	BIRC3 BIRC2 TRAF2	Regulation of necroptotic cell death
WP:WP5039	0.000493027122713	0.3	CXCL1 TRAF2 TANK	SARS CoV 2 innate immunity evasion and cell specific immune response
KEGG:04622	0.000496184652725	0.3	TANK TRAF2 IKBKE	RIG-I-like receptor signaling pathway
WP:WP3865	0.000552952277359	0.3	TANK TRAF2 IKBKE	Novel intracellular components of RIG I like receptor pathway
GO:0071356	0.000602766582881	0.5	BIRC3 TRAF1 BIRC2 TRAF2 TANK	cellular response to tumor necrosis factor
KEGG:04657	0.000827367271254	0.3	CXCL1 TRAF2 IKBKE	IL-17 signaling pathway
CORUM:5212	0.000859331699025	0.2	TANK TRAF2	Kinase maturation complex 2
GO:0009898	0.000943475289248	0.5	DIABLO TRAF1 BIRC2 TRAF2 HTRA2	cytoplasmic side of plasma membrane
GO:0034612	0.00104888708432	0.5	BIRC3 TRAF1 BIRC2 TRAF2 TANK	response to tumor necrosis factor
REAC:R-HSA-5218859	0.0012820759141	0.3	BIRC3 BIRC2 TRAF2	Regulated Necrosis
REAC:R-HSA-5357801	0.00143440477259	0.4	BIRC3 BIRC2 TRAF2 DIABLO	Programmed Cell Death
GO:0007166	0.00185293618199	0.9	IKBKE DIABLO TRAF2 HTRA2 BIRC3 TRAF1 TANK CXCL1 BIRC2	cell surface receptor signaling pathway
GO:0071310	0.00188912174148	0.8	IKBKE TANK TRAF2 HTRA2 BIRC3 TRAF1 CXCL1 BIRC2	cellular response to organic substance
REAC:R-HSA-168249	0.00203163690761	0.6	TANK IKBKE TRAF2 BIRC3 CXCL1 BIRC2	Innate Immune System
GO:0098562	0.00263439368565	0.5	DIABLO TRAF1 BIRC2 TRAF2 HTRA2	cytoplasmic side of membrane
CORUM:6344	0.00278671748515	0.2	BIRC3 TRAF2	TNF-R1-associated signaling complex
GO:0035556	0.00293544573079	0.9	IKBKE DIABLO TRAF2 HTRA2 BIRC3 TRAF1 TANK CXCL1 BIRC2	intracellular signal transduction
REAC:R-HSA-168928	0.00366640411985	0.3	TANK TRAF2 IKBKE	DDX58/IFIH1-mediated induction of interferon-alpha/beta
KEGG:05168	0.00366907782272	0.4	BIRC3 IKBKE BIRC2 TRAF2	Herpes simplex virus 1 infection
WP:WP5182	0.00375768007348	0.2	BIRC3 TRAF2	Pro survival signaling of neuroprotectin D1
GO:0052547	0.0045538824629	0.5	BIRC3 DIABLO TANK BIRC2 HTRA2	regulation of peptidase activity
KEGG:04217	0.00464015230994	0.3	BIRC3 BIRC2 TRAF2	Necroptosis
REAC:R-HSA-5668541	0.00553477986945	0.3	BIRC3 BIRC2 TRAF2	TNFR2 non-canonical NF-kB pathway
GO:0033209	0.00555894987576	0.4	BIRC3 TRAF1 BIRC2 TRAF2	tumor necrosis factor-mediated signaling pathway
REAC:R-HSA-9013973	0.00669318453569	0.2	TANK IKBKE	TICAM1-dependent activation of IRF3/IRF7
KEGG:05202	0.00669362487232	0.3	BIRC3 BIRC2 TRAF1	Transcriptional misregulation in cancer
WP:WP2507	0.00704825789595	0.2	DIABLO HTRA2	Nanomaterial induced apoptosis
KEGG:05200	0.00781674670163	0.4	BIRC3 TRAF1 BIRC2 TRAF2	Pathways in cancer
KEGG:05167	0.00849596419776	0.3	CXCL1 TRAF2 IKBKE	Kaposi sarcoma-associated herpesvirus infection
REAC:R-HSA-936964	0.00922174626729	0.2	TANK IKBKE	Activation of IRF3, IRF7 mediated by TBK1, IKBKE
GO:0010033	0.0124084667845	0.8	IKBKE TANK TRAF2 HTRA2 BIRC3 TRAF1 CXCL1 BIRC2	response to organic substance
WP:WP4950	0.0133616217617	0.2	TRAF2 TRAF1	16p11 2 distal deletion syndrome
GO:0065009	0.0144267386478	0.8	IKBKE DIABLO TRAF2 HTRA2 BIRC3 TRAF1 TANK BIRC2	regulation of molecular function
WP:WP5406	0.0155292506893	0.2	TRAF2 TRAF1	13q12 12 copy number variation
REAC:R-HSA-168927	0.0172971739669	0.2	BIRC3 BIRC2	TICAM1, RIP1-mediated IKK complex recruitment
WP:WP3617	0.0178579187559	0.2	BIRC3 BIRC2	Photodynamic therapy induced NF kB survival signaling
REAC:R-HSA-937041	0.0192120670931	0.2	BIRC3 BIRC2	IKK complex recruitment mediated by RIP1
KEGG:05132	0.0198241007008	0.3	BIRC3 BIRC2 TRAF2	Salmonella infection
WP:WP3941	0.025806598747	0.2	TRAF2 TRAF1	Oxidative damage response
GO:0070887	0.0309061126232	0.8	IKBKE TANK TRAF2 HTRA2 BIRC3 TRAF1 CXCL1 BIRC2	cellular response to chemical stimulus
REAC:R-HSA-109581	0.0393375504084	0.3	DIABLO BIRC2 TRAF2	Apoptosis
WP:WP2018	0.0422420407673	0.2	TRAF2 TRAF1	RANKL RANK signaling pathway
REAC:R-HSA-5689880	0.0483498248961	0.3	BIRC3 BIRC2 TRAF2	Ub-specific processing proteases
REAC:R-HSA-168638	0.0499343626014	0.2	BIRC3 BIRC2	NOD1/2 Signaling Pathway
KEGG:01524	0.0499839039158	0.2	BIRC3 BIRC2	Platinum drug resistance

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TRAF2	TRAF1	1.0	0.088	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	DIABLO	1.0	0.128	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	TRAF1	0.999	0.166	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TANK	TRAF1	0.999	0.136	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TANK	TRAF2	0.999	0.148952380952	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	TRAF2	0.999	0.2272	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	HTRA2	0.998	0.124	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TRAF2	DIABLO	0.996	0.074	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
BIRC2	CXCL1	0.995		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
HTRA2	TRAF2	0.994	0.034	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
TANK	DIABLO	0.993	0.128	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CXCL1	TRAF2	0.987		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TRAF1	DIABLO	0.986	0.168	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	NFIC	0.984	0.12	bioplex3_WMM bioplex3_HCT116 WMM_only
TANK	IKBKE	0.98		bioplex3_HEK293 bioplex3_WMM WMM_only
HTRA2	TRAF1	0.98	0.092	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TRAF2	IKBKE	0.976		bioplex3_WMM bioplex3_HCT116 WMM_only
HTRA2	DIABLO	0.973	0.374	bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CXCL3	CXCL1	0.972		bioplex3_HEK293 bioplex3_WMM WMM_only
BIRC3	TRAF2	0.969		bioplex3_WMM bioplex3_HCT116 WMM_only
BIRC3	TRAF1	0.966		bioplex3_WMM bioplex3_HCT116 WMM_only
BIRC3	DIABLO	0.964		bioplex3_WMM bioplex3_HCT116 WMM_only
BIRC2	TANK	0.955	0.172	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
HTRA2	TANK	0.952	0.096	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
CXCL1	DIABLO	0.952		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CXCL3	TRAF2	0.928		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
BIRC3	IKBKE	0.892		bioplex3_WMM WMM_only
BIRC2	CXCL3	0.797		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TRAF1	IKBKE	0.796		bioplex3_WMM WMM_only
BIRC2	IKBKE	0.492		bioplex3_WMM WMM_only
HTRA2	IKBKE	0.451		bioplex3_WMM WMM_only
BIRC2	BIRC3	0.438		bioplex3_WMM WMM_only
NFIC	TRAF2	0.389	0.026	bioplex3_WMM WMM_only
BIRC3	TANK	0.384		bioplex3_WMM WMM_only
IKBKE	DIABLO	0.374		bioplex3_WMM WMM_only
BIRC3	HTRA2	0.306		bioplex3_WMM WMM_only
NFIC	HTRA2	0.181	0.04	bioplex3_WMM WMM_only
NFIC	DIABLO	0.147	0.09	bioplex3_WMM youn_WMM WMM_only
CXCL1	TANK	0.043		bioplex3_WMM bioplex3_HCT116 WMM_only
NFIC	TRAF1	0.042	0.092	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
BIRC2	huMAP3_00079.1 huMAP3_05765.1 huMAP3_07387.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
CXCL1	huMAP3_02215.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12588.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13249.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
HTRA2	huMAP3_02517.1 huMAP3_03100.1 huMAP3_03925.1 huMAP3_05775.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_08787.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09818.1 huMAP3_09978.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1
NFIC	huMAP3_00079.1 huMAP3_01226.1 huMAP3_03709.1 huMAP3_08064.1 huMAP3_08589.1 huMAP3_09978.1 huMAP3_10288.1 huMAP3_12111.1 huMAP3_13816.1
CXCL3	huMAP3_02215.1 huMAP3_04193.1 huMAP3_06150.1 huMAP3_09978.1 huMAP3_11292.1 huMAP3_12588.1 huMAP3_12680.1 huMAP3_13249.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
BIRC3	huMAP3_01302.1 huMAP3_02031.1 huMAP3_02285.1 huMAP3_02517.1 huMAP3_03925.1 huMAP3_05158.1 huMAP3_05694.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_08312.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
DIABLO	huMAP3_05765.1 huMAP3_06254.1 huMAP3_07387.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TANK	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TRAF2	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TRAF1	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_14463.1 huMAP3_15146.1 huMAP3_15257.1
IKBKE	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_09978.1