hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_09978.1

Complex Portal: CPX-11310

Confidence: Medium High

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Genename	Protein Name	Uniprot Annotation Score	Links
BIRC2	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	5	UniProt NCBI
BIRC3	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)	5	UniProt NCBI
CXCL1	Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]	5	UniProt NCBI
CXCL3	C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]	5	UniProt NCBI
DIABLO	Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]	5	UniProt NCBI
HTRA2	Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)	5	UniProt NCBI
IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)	5	UniProt NCBI
NFIC	Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)	5	UniProt NCBI
TANK	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	5	UniProt NCBI
TRAF1	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)	5	UniProt NCBI

Showing 1 to 10 of 11 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP231	6.10075928061e-10	0.6	BIRC3 BIRC2 TRAF1 DIABLO TRAF2 TANK	TNF alpha signaling pathway
KEGG:04210	2.78091592761e-09	0.6	BIRC3 BIRC2 TRAF1 HTRA2 DIABLO TRAF2	Apoptosis
KEGG:04621	9.17263048828e-09	0.6	CXCL1 BIRC2 BIRC3 TRAF2 IKBKE TANK	NOD-like receptor signaling pathway
REAC:R-HSA-5357905	1.17728545642e-08	0.5	BIRC3 TRAF1 IKBKE BIRC2 TRAF2	Regulation of TNFR1 signaling
REAC:R-HSA-75893	3.10288498637e-08	0.5	BIRC3 TRAF1 IKBKE BIRC2 TRAF2	TNF signaling
KEGG:04064	5.37690461794e-08	0.5	CXCL1 TRAF1 BIRC2 TRAF2 BIRC3	NF-kappa B signaling pathway
WP:WP254	6.58010695697e-08	0.5	BIRC3 TRAF1 BIRC2 TRAF2 DIABLO	Apoptosis
KEGG:04668	1.29036955539e-07	0.5	CXCL1 TRAF1 BIRC2 TRAF2 BIRC3	TNF signaling pathway
KEGG:04215	1.31083166186e-07	0.4	BIRC3 DIABLO BIRC2 HTRA2	Apoptosis - multiple species
REAC:R-HSA-5357786	2.8179151173e-07	0.4	BIRC3 IKBKE BIRC2 TRAF2	TNFR1-induced proapoptotic signaling

Showing 1 to 10 of 79 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TRAF2	TRAF1	1.0	0.088	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	DIABLO	1.0	0.128		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	TRAF1	0.999	0.166	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TANK	TRAF1	0.999	0.136		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TANK	TRAF2	0.999	0.148952380952		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	TRAF2	0.999	0.2272	mutually_exclusive (Q13077)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC2	HTRA2	0.998	0.124		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TRAF2	DIABLO	0.996	0.074	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
BIRC2	CXCL1	0.995			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
HTRA2	TRAF2	0.994	0.034		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116

Showing 1 to 10 of 40 entries

Related Complexes

Genename	Complexes
BIRC2	huMAP3_00079.1 huMAP3_05765.1 huMAP3_07387.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
CXCL1	huMAP3_02215.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12588.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13249.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
HTRA2	huMAP3_02517.1 huMAP3_03100.1 huMAP3_03925.1 huMAP3_05775.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_08787.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09818.1 huMAP3_09978.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1
NFIC	huMAP3_00079.1 huMAP3_01226.1 huMAP3_03709.1 huMAP3_08064.1 huMAP3_08589.1 huMAP3_09978.1 huMAP3_10288.1 huMAP3_12111.1 huMAP3_13816.1
CXCL3	huMAP3_02215.1 huMAP3_04193.1 huMAP3_06150.1 huMAP3_09978.1 huMAP3_11292.1 huMAP3_12588.1 huMAP3_12680.1 huMAP3_13249.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
BIRC3	huMAP3_01302.1 huMAP3_02031.1 huMAP3_02285.1 huMAP3_02517.1 huMAP3_03925.1 huMAP3_05158.1 huMAP3_05694.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_08312.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
DIABLO	huMAP3_05765.1 huMAP3_06254.1 huMAP3_07387.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TANK	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TRAF2	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TRAF1	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_14463.1 huMAP3_15146.1 huMAP3_15257.1
IKBKE	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1