hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_09978.1
Complex Portal: CPX-11310
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BIRC2 | Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) | 5 | UniProt NCBI |
| CXCL1 | Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| NFIC | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | 5 | UniProt NCBI |
| CXCL3 | C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)] | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| DIABLO | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP231 | 6.10075928061e-10 | 0.6 | BIRC2 BIRC3 TRAF1 TRAF2 DIABLO TANK | TNF alpha signaling pathway |
| KEGG:04210 | 2.78091592761e-09 | 0.6 | BIRC2 BIRC3 TRAF1 TRAF2 DIABLO HTRA2 | Apoptosis |
| KEGG:04621 | 9.17263048828e-09 | 0.6 | BIRC2 IKBKE TRAF2 TANK CXCL1 BIRC3 | NOD-like receptor signaling pathway |
| REAC:R-HSA-5357905 | 1.17728545642e-08 | 0.5 | BIRC2 IKBKE TRAF1 BIRC3 TRAF2 | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 3.10288498637e-08 | 0.5 | BIRC2 IKBKE TRAF1 BIRC3 TRAF2 | TNF signaling |
| KEGG:04064 | 5.37690461794e-08 | 0.5 | TRAF2 BIRC2 TRAF1 BIRC3 CXCL1 | NF-kappa B signaling pathway |
| WP:WP254 | 6.58010695697e-08 | 0.5 | TRAF2 BIRC2 TRAF1 BIRC3 DIABLO | Apoptosis |
| KEGG:04668 | 1.29036955539e-07 | 0.5 | TRAF2 BIRC2 TRAF1 BIRC3 CXCL1 | TNF signaling pathway |
| KEGG:04215 | 1.31083166186e-07 | 0.4 | BIRC2 BIRC3 DIABLO HTRA2 | Apoptosis - multiple species |
| REAC:R-HSA-5357786 | 2.8179151173e-07 | 0.4 | BIRC2 IKBKE BIRC3 TRAF2 | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-168164 | 4.9739671933e-07 | 0.5 | TRAF2 BIRC2 IKBKE BIRC3 TANK | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 5.55549716703e-07 | 0.5 | TRAF2 BIRC2 IKBKE BIRC3 TANK | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 5.55549716703e-07 | 0.5 | TRAF2 BIRC2 IKBKE BIRC3 TANK | MyD88-independent TLR4 cascade |
| WP:WP2036 | 6.34019510892e-07 | 0.4 | BIRC2 TRAF1 BIRC3 TRAF2 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-5357956 | 9.51119385451e-07 | 0.4 | BIRC2 TRAF1 BIRC3 TRAF2 | TNFR1-induced NF-kappa-B signaling pathway |
| GO:0071345 | 1.16809645239e-06 | 0.8 | BIRC2 BIRC3 TRAF1 TRAF2 HTRA2 TANK CXCL1 IKBKE | cellular response to cytokine stimulus |
| GO:0035631 | 1.81927560642e-06 | 0.4 | TRAF2 BIRC2 DIABLO HTRA2 | CD40 receptor complex |
| REAC:R-HSA-166016 | 2.28992459356e-06 | 0.5 | TRAF2 BIRC2 IKBKE BIRC3 TANK | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 2.69125735642e-06 | 0.5 | BIRC2 IKBKE TRAF1 BIRC3 TRAF2 | Death Receptor Signaling |
| GO:0034097 | 2.9986604368e-06 | 0.8 | BIRC2 BIRC3 TRAF1 TRAF2 HTRA2 TANK CXCL1 IKBKE | response to cytokine |
| REAC:R-HSA-168898 | 4.72283997553e-06 | 0.5 | TRAF2 BIRC2 IKBKE BIRC3 TANK | Toll-like Receptor Cascades |
| REAC:R-HSA-5676594 | 9.16769422079e-06 | 0.3 | BIRC2 BIRC3 TRAF2 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| KEGG:05222 | 1.15020714318e-05 | 0.4 | BIRC2 TRAF1 BIRC3 TRAF2 | Small cell lung cancer |
| WP:WP1772 | 1.51423209535e-05 | 0.4 | BIRC2 BIRC3 DIABLO HTRA2 | Apoptosis modulation and signaling |
| GO:0019221 | 1.59042523128e-05 | 0.7 | BIRC2 BIRC3 TRAF1 TRAF2 TANK CXCL1 IKBKE | cytokine-mediated signaling pathway |
| WP:WP4658 | 2.5825431588e-05 | 0.4 | BIRC2 TRAF1 BIRC3 TRAF2 | Small cell lung cancer |
| CORUM:5529 | 3.07577115383e-05 | 0.2 | BIRC2 TRAF2 | TRAF2-cIAP1/BIRC2 complex |
| GO:0043122 | 8.93403909543e-05 | 0.6 | BIRC2 IKBKE TRAF1 TRAF2 TANK BIRC3 | regulation of canonical NF-kappaB signal transduction |
| CORUM:5531 | 9.22394575203e-05 | 0.2 | BIRC2 TRAF2 | Tumor necrosis factor receptor 1 signaling complex |
| CORUM:5210 | 9.22394575203e-05 | 0.2 | TRAF2 TANK | TANK-TRAF2-TRAF3 complex |
| GO:0007249 | 0.000165538747619 | 0.6 | BIRC2 IKBKE TRAF1 TRAF2 TANK BIRC3 | canonical NF-kappaB signal transduction |
| REAC:R-HSA-933541 | 0.000201713088963 | 0.3 | TRAF2 TANK IKBKE | TRAF6 mediated IRF7 activation |
| KEGG:05417 | 0.000222091335709 | 0.4 | CXCL1 IKBKE TANK TRAF2 | Lipid and atherosclerosis |
| REAC:R-HSA-5213460 | 0.000224045063065 | 0.3 | BIRC2 BIRC3 TRAF2 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.000224045063065 | 0.3 | BIRC2 BIRC3 TRAF2 | Regulation of necroptotic cell death |
| WP:WP5039 | 0.000493027122713 | 0.3 | CXCL1 TANK TRAF2 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| KEGG:04622 | 0.000496184652725 | 0.3 | TRAF2 TANK IKBKE | RIG-I-like receptor signaling pathway |
| WP:WP3865 | 0.000552952277359 | 0.3 | TRAF2 TANK IKBKE | Novel intracellular components of RIG I like receptor pathway |
| GO:0071356 | 0.000602766582881 | 0.5 | TRAF2 BIRC2 TRAF1 BIRC3 TANK | cellular response to tumor necrosis factor |
| KEGG:04657 | 0.000827367271254 | 0.3 | CXCL1 IKBKE TRAF2 | IL-17 signaling pathway |
| CORUM:5212 | 0.000859331699025 | 0.2 | TRAF2 TANK | Kinase maturation complex 2 |
| GO:0009898 | 0.000943475289248 | 0.5 | TRAF2 BIRC2 TRAF1 DIABLO HTRA2 | cytoplasmic side of plasma membrane |
| GO:0034612 | 0.00104888708432 | 0.5 | TRAF2 BIRC2 TRAF1 BIRC3 TANK | response to tumor necrosis factor |
| REAC:R-HSA-5218859 | 0.0012820759141 | 0.3 | BIRC2 BIRC3 TRAF2 | Regulated Necrosis |
| REAC:R-HSA-5357801 | 0.00143440477259 | 0.4 | TRAF2 BIRC2 BIRC3 DIABLO | Programmed Cell Death |
| GO:0007166 | 0.00185293618199 | 0.9 | BIRC2 BIRC3 TRAF1 CXCL1 DIABLO HTRA2 TANK TRAF2 IKBKE | cell surface receptor signaling pathway |
| GO:0071310 | 0.00188912174148 | 0.8 | BIRC2 BIRC3 TRAF1 TRAF2 HTRA2 TANK CXCL1 IKBKE | cellular response to organic substance |
| REAC:R-HSA-168249 | 0.00203163690761 | 0.6 | BIRC2 IKBKE TRAF2 TANK CXCL1 BIRC3 | Innate Immune System |
| GO:0098562 | 0.00263439368565 | 0.5 | TRAF2 BIRC2 TRAF1 DIABLO HTRA2 | cytoplasmic side of membrane |
| CORUM:6344 | 0.00278671748515 | 0.2 | TRAF2 BIRC3 | TNF-R1-associated signaling complex |
| GO:0035556 | 0.00293544573079 | 0.9 | BIRC2 BIRC3 TRAF1 CXCL1 DIABLO HTRA2 TANK TRAF2 IKBKE | intracellular signal transduction |
| REAC:R-HSA-168928 | 0.00366640411985 | 0.3 | TRAF2 TANK IKBKE | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:05168 | 0.00366907782272 | 0.4 | BIRC2 IKBKE BIRC3 TRAF2 | Herpes simplex virus 1 infection |
| WP:WP5182 | 0.00375768007348 | 0.2 | TRAF2 BIRC3 | Pro survival signaling of neuroprotectin D1 |
| GO:0052547 | 0.0045538824629 | 0.5 | BIRC2 TANK BIRC3 DIABLO HTRA2 | regulation of peptidase activity |
| KEGG:04217 | 0.00464015230994 | 0.3 | BIRC2 BIRC3 TRAF2 | Necroptosis |
| REAC:R-HSA-5668541 | 0.00553477986945 | 0.3 | BIRC2 BIRC3 TRAF2 | TNFR2 non-canonical NF-kB pathway |
| GO:0033209 | 0.00555894987576 | 0.4 | BIRC2 TRAF1 BIRC3 TRAF2 | tumor necrosis factor-mediated signaling pathway |
| REAC:R-HSA-9013973 | 0.00669318453569 | 0.2 | TANK IKBKE | TICAM1-dependent activation of IRF3/IRF7 |
| KEGG:05202 | 0.00669362487232 | 0.3 | BIRC2 BIRC3 TRAF1 | Transcriptional misregulation in cancer |
| WP:WP2507 | 0.00704825789595 | 0.2 | HTRA2 DIABLO | Nanomaterial induced apoptosis |
| KEGG:05200 | 0.00781674670163 | 0.4 | BIRC2 TRAF1 BIRC3 TRAF2 | Pathways in cancer |
| KEGG:05167 | 0.00849596419776 | 0.3 | CXCL1 IKBKE TRAF2 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-936964 | 0.00922174626729 | 0.2 | TANK IKBKE | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| GO:0010033 | 0.0124084667845 | 0.8 | BIRC2 BIRC3 TRAF1 TRAF2 HTRA2 TANK CXCL1 IKBKE | response to organic substance |
| WP:WP4950 | 0.0133616217617 | 0.2 | TRAF2 TRAF1 | 16p11 2 distal deletion syndrome |
| GO:0065009 | 0.0144267386478 | 0.8 | BIRC2 BIRC3 TRAF1 TRAF2 DIABLO HTRA2 TANK IKBKE | regulation of molecular function |
| WP:WP5406 | 0.0155292506893 | 0.2 | TRAF2 TRAF1 | 13q12 12 copy number variation |
| REAC:R-HSA-168927 | 0.0172971739669 | 0.2 | BIRC2 BIRC3 | TICAM1, RIP1-mediated IKK complex recruitment |
| WP:WP3617 | 0.0178579187559 | 0.2 | BIRC2 BIRC3 | Photodynamic therapy induced NF kB survival signaling |
| REAC:R-HSA-937041 | 0.0192120670931 | 0.2 | BIRC2 BIRC3 | IKK complex recruitment mediated by RIP1 |
| KEGG:05132 | 0.0198241007008 | 0.3 | BIRC2 BIRC3 TRAF2 | Salmonella infection |
| WP:WP3941 | 0.025806598747 | 0.2 | TRAF2 TRAF1 | Oxidative damage response |
| GO:0070887 | 0.0309061126232 | 0.8 | BIRC2 BIRC3 TRAF1 TRAF2 HTRA2 TANK CXCL1 IKBKE | cellular response to chemical stimulus |
| REAC:R-HSA-109581 | 0.0393375504084 | 0.3 | BIRC2 DIABLO TRAF2 | Apoptosis |
| WP:WP2018 | 0.0422420407673 | 0.2 | TRAF2 TRAF1 | RANKL RANK signaling pathway |
| REAC:R-HSA-5689880 | 0.0483498248961 | 0.3 | BIRC2 BIRC3 TRAF2 | Ub-specific processing proteases |
| REAC:R-HSA-168638 | 0.0499343626014 | 0.2 | BIRC2 BIRC3 | NOD1/2 Signaling Pathway |
| KEGG:01524 | 0.0499839039158 | 0.2 | BIRC2 BIRC3 | Platinum drug resistance |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TRAF2 | TRAF1 | 1.0 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BIRC2 | DIABLO | 1.0 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BIRC2 | TRAF1 | 0.999 | 0.166 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF1 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BIRC2 | TRAF2 | 0.999 | 0.2272 |
mutually_exclusive (Q13077)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BIRC2 | HTRA2 | 0.998 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRAF2 | DIABLO | 0.996 | 0.074 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| BIRC2 | CXCL1 | 0.995 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HTRA2 | TRAF2 | 0.994 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| TANK | DIABLO | 0.993 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CXCL1 | TRAF2 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TRAF1 | DIABLO | 0.986 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BIRC2 | NFIC | 0.984 | 0.12 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| HTRA2 | TRAF1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HTRA2 | DIABLO | 0.973 | 0.374 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| CXCL3 | CXCL1 | 0.972 |
mutually_exclusive (P19875)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| BIRC3 | TRAF2 | 0.969 |
mutually_exclusive (Q9NR28)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF1 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BIRC3 | DIABLO | 0.964 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC2 | TANK | 0.955 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| HTRA2 | TANK | 0.952 | 0.096 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CXCL1 | DIABLO | 0.952 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CXCL3 | TRAF2 | 0.928 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | ||
| BIRC2 | CXCL3 | 0.797 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TRAF1 | IKBKE | 0.796 | bioplex3_WMM WMM_only | ||
| BIRC2 | IKBKE | 0.492 | bioplex3_WMM WMM_only | ||
| HTRA2 | IKBKE | 0.451 | bioplex3_WMM WMM_only | ||
| BIRC2 | BIRC3 | 0.438 | bioplex3_WMM WMM_only | ||
| NFIC | TRAF2 | 0.389 | 0.026 | bioplex3_WMM WMM_only | |
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | ||
| IKBKE | DIABLO | 0.374 | bioplex3_WMM WMM_only | ||
| BIRC3 | HTRA2 | 0.306 | bioplex3_WMM WMM_only | ||
| NFIC | HTRA2 | 0.181 | 0.04 | bioplex3_WMM WMM_only | |
| NFIC | DIABLO | 0.147 | 0.09 | bioplex3_WMM youn_WMM WMM_only | |
| CXCL1 | TANK | 0.043 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NFIC | TRAF1 | 0.042 | 0.092 | bioplex3_WMM WMM_only |
Related Complexes