hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09979.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARHGEF38 | Rho guanine nucleotide exchange factor 38 | 4 | UniProt NCBI |
| MTCL2 | Microtubule cross-linking factor 2 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)] | 5 | UniProt NCBI |
| MARK2 | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | 5 | UniProt NCBI |
| CLASP2 | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | 5 | UniProt NCBI |
| CLASP1 | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428890 | 0.000425287580531 | 0.4 | CLASP2 CLASP1 | Role of ABL in ROBO-SLIT signaling |
| WP:WP2038 | 0.00528162918062 | 0.4 | MARK2 CLASP1 | Microtubule cytoskeleton regulation |
| WP:WP4932 | 0.0264781270697 | 0.4 | CLASP2 CLASP1 | 7q11 23 copy number variation syndrome |
| GO:1903690 | 0.0280843539964 | 0.4 | CLASP2 CLASP1 | negative regulation of wound healing, spreading of epidermal cells |
| GO:0030981 | 0.0468008499735 | 0.4 | CLASP2 CLASP1 | cortical microtubule cytoskeleton |
| GO:0045180 | 0.0468008499735 | 0.4 | CLASP2 CLASP1 | basal cortex |
| GO:1904259 | 0.0468008499735 | 0.4 | CLASP2 CLASP1 | regulation of basement membrane assembly involved in embryonic body morphogenesis |
| GO:1904261 | 0.0468008499735 | 0.4 | CLASP2 CLASP1 | positive regulation of basement membrane assembly involved in embryonic body morphogenesis |
| GO:2001197 | 0.0468008499735 | 0.4 | CLASP2 CLASP1 | basement membrane assembly involved in embryonic body morphogenesis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CLASP1 | CLASP2 | 0.993 | 0.12 | hein_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM |
| MARK2 | MTCL2 | 0.987 | 0.048 | hein_WMM bioplex3_WMM boldt hein () boldt_WMM |
| CLASP1 | MTCL2 | 0.976 | 0.08 | hein_WMM bioplex3_WMM youn_WMM hein () treiber_WMM |
| MARK2 | CLASP2 | 0.967 | 0.12 | hein_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM |
| CLASP2 | MTCL2 | 0.963 | 0.022 | hein_WMM bioplex3_WMM boldt hein () boldt_WMM |
| CLASP1 | ARHGEF38 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CLASP1 | MARK2 | 0.688 | 0.138 | hein_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
Related Complexes