hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_09997.1
Complex Portal: CPX-17145
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLK14 | Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6) | 5 | UniProt NCBI |
| SPRR1A | Cornifin-A (19 kDa pancornulin) (SPRK) (Small proline-rich protein IA) (SPR-IA) | 5 | UniProt NCBI |
| DMKN | Dermokine (Epidermis-specific secreted protein SK30/SK89) | 5 | UniProt NCBI |
| SPRR1B | Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB) | 5 | UniProt NCBI |
| PITHD1 | PITH domain-containing protein 1 | 4 | UniProt NCBI |
| NUDT3 | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) | 5 | UniProt NCBI |
| ZDHHC19 | Palmitoyltransferase ZDHHC19 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 19) (DHHC-19) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6809371 | 0.000616493605077 | 0.428571428571 | KLK14 SPRR1B SPRR1A | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.000673985363387 | 0.428571428571 | KLK14 SPRR1B SPRR1A | Keratinization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KLK14 | ZDHHC19 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DMKN | ZDHHC19 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SPRR1A | ZDHHC19 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SPRR1A | NUDT3 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZDHHC19 | SPRR1B | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZDHHC19 | PITHD1 | 0.971 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NUDT3 | SPRR1B | 0.97 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPRR1A | SPRR1B | 0.826 | bioplex3_WMM WMM_only boldt_WMM | ||
| DMKN | PITHD1 | 0.625 | bioplex3_WMM WMM_only | ||
| SPRR1A | KLK14 | 0.405 | bioplex3_WMM WMM_only | ||
| KLK14 | SPRR1B | 0.356 | bioplex3_WMM WMM_only | ||
| KLK14 | DMKN | 0.356 | bioplex3_WMM WMM_only | ||
| KLK14 | PITHD1 | 0.356 | bioplex3_WMM WMM_only | ||
| DMKN | SPRR1B | 0.336 | bioplex3_WMM WMM_only | ||
| SPRR1A | DMKN | 0.334 | bioplex3_WMM WMM_only | ||
| SPRR1A | PITHD1 | 0.133 | bioplex3_WMM WMM_only | ||
| PITHD1 | SPRR1B | 0.096 | 0.04 | bioplex3_WMM WMM_only |
Related Complexes