hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10003.1

Complex Portal: CPX-17970

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
COL13A1	Collagen alpha-1(XIII) chain (COLXIIIA1)	5	UniProt NCBI
COL21A1	Collagen alpha-1(XXI) chain	5	UniProt NCBI
PLOD3	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]	5	UniProt NCBI
COLGALT2	Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2)	5	UniProt NCBI
DOK1	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)	5	UniProt NCBI
VPS33B	Vacuolar protein sorting-associated protein 33B (hVPS33B)	5	UniProt NCBI
COL9A2	Collagen alpha-2(IX) chain	5	UniProt NCBI
COL4A2	Collagen alpha-2(IV) chain [Cleaved into: Canstatin]	5	UniProt NCBI
VIPAS39	Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)	5	UniProt NCBI
COL9A3	Collagen alpha-3(IX) chain	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1650814	1.36311711216e-13	0.7	PLOD3 COL13A1 COL9A2 COL4A2 COL9A3 COLGALT2 COL21A1	Collagen biosynthesis and modifying enzymes
REAC:R-HSA-1474290	1.49553422321e-12	0.7	PLOD3 COL13A1 COL9A2 COL4A2 COL9A3 COLGALT2 COL21A1	Collagen formation
REAC:R-HSA-8948216	1.5510254452e-09	0.5	COL9A2 COL4A2 COL13A1 COL9A3 COL21A1	Collagen chain trimerization
REAC:R-HSA-1474244	5.71493420219e-09	0.7	PLOD3 COL13A1 COL9A2 COL4A2 COL9A3 COLGALT2 COL21A1	Extracellular matrix organization
KEGG:04974	2.52158623113e-08	0.5	COL9A2 COL4A2 COL13A1 COL9A3 COL21A1	Protein digestion and absorption
GO:0030020	2.67628307587e-07	0.5	COL9A2 COL4A2 COL13A1 COL9A3 COL21A1	extracellular matrix structural constituent conferring tensile strength
REAC:R-HSA-1442490	5.57272313106e-06	0.4	COL9A2 COL13A1 COL9A3 COL4A2	Collagen degradation
REAC:R-HSA-216083	1.55950062043e-05	0.4	COL9A2 COL13A1 COL9A3 COL4A2	Integrin cell surface interactions
GO:0030198	2.45883561591e-05	0.6	PLOD3 COL13A1 COL9A2 COL4A2 COL9A3 COLGALT2	extracellular matrix organization
GO:0043062	2.45883561591e-05	0.6	PLOD3 COL13A1 COL9A2 COL4A2 COL9A3 COLGALT2	extracellular structure organization
GO:0045229	2.63689804701e-05	0.6	PLOD3 COL13A1 COL9A2 COL4A2 COL9A3 COLGALT2	external encapsulating structure organization
CORUM:6390	3.07577115383e-05	0.2	VIPAS39 VPS33B	Endosomal targeting complex (VIPAS39-VPS33B)
GO:0005581	4.86250232062e-05	0.4	COL9A2 COL13A1 COL9A3 COL4A2	collagen trimer
REAC:R-HSA-1474228	0.000123429301917	0.4	COL9A2 COL13A1 COL9A3 COL4A2	Degradation of the extracellular matrix
HPA:0200273	0.000155625685718	0.2	COL9A2 COL9A3	eye; hyaloid membrane[High]
REAC:R-HSA-419037	0.000161586017522	0.3	COL9A2 COL4A2 COL9A3	NCAM1 interactions
GO:0005788	0.000217631473536	0.6	COL13A1 COL9A2 COL4A2 COL9A3 COLGALT2 COL21A1	endoplasmic reticulum lumen
HPA:0200272	0.000311137772808	0.2	COL9A2 COL9A3	eye; hyaloid membrane[>=Medium]
HPA:0070113	0.000311137772808	0.2	COL9A2 COL9A3	cartilage; chondrocytes[High]
HPA:0200271	0.000311137772808	0.2	COL9A2 COL9A3	eye; hyaloid membrane[>=Low]
GO:0005201	0.000322887520667	0.5	COL9A2 COL4A2 COL13A1 COL9A3 COL21A1	extracellular matrix structural constituent
KEGG:04512	0.000543786983792	0.3	COL9A2 COL4A2 COL9A3	ECM-receptor interaction
WP:WP4789	0.000621209367045	0.2	COL9A2 COL9A3	MED and pseudoachondroplasia genes
REAC:R-HSA-375165	0.000630778022304	0.3	COL9A2 COL4A2 COL9A3	NCAM signaling for neurite out-growth
GO:0017185	0.000644767051209	0.3	PLOD3 VPS33B VIPAS39	peptidyl-lysine hydroxylation
REAC:R-HSA-2022090	0.000889345061537	0.3	COL9A2 COL4A2 COL9A3	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-186797	0.000948293432838	0.3	COL9A2 COL4A2 COL9A3	Signaling by PDGF
HPA:0070112	0.0010877902762	0.2	COL9A2 COL9A3	cartilage; chondrocytes[>=Medium]
HPA:0070000	0.0010877902762	0.2	COL9A2 COL9A3	cartilage
HPA:0070111	0.0010877902762	0.2	COL9A2 COL9A3	cartilage; chondrocytes[>=Low]
HP:0003946	0.00123890251767	0.2	COL9A2 COL9A3	Abnormality of the epiphyses of the elbow
HP:0003841	0.00123890251767	0.2	COL9A2 COL9A3	Fragmented epiphyses of the upper limbs
HP:0009189	0.00123890251767	0.2	COL9A2 COL9A3	Fragmentation of the metacarpal epiphyses
HP:0012770	0.00123890251767	0.2	COL9A2 COL9A3	Reduced arm span
HP:0006190	0.00123890251767	0.2	COL9A2 COL9A3	Radially deviated wrists
REAC:R-HSA-3000178	0.00168567421844	0.3	COL9A2 COL4A2 COL9A3	ECM proteoglycans
HP:0006055	0.00247690070118	0.2	COL9A2 COL9A3	Ulnar deviated club hands
HP:0200084	0.00247690070118	0.2	VIPAS39 VPS33B	Giant cell hepatitis
HP:0003999	0.00412666115323	0.2	COL9A2 COL9A3	Abnormality of radial epiphyses
HP:0100168	0.00412666115323	0.2	COL9A2 COL9A3	Fragmented epiphyses
HP:0009806	0.0061877325188	0.2	VIPAS39 VPS33B	Nephrogenic diabetes insipidus
HP:0010631	0.0061877325188	0.2	COL9A2 COL9A3	Abnormality of the epiphyses of the feet
GO:0018126	0.00642915610421	0.3	PLOD3 VPS33B VIPAS39	protein hydroxylation
HP:0003272	0.00814873741057	0.5	COL9A2 VIPAS39 COL13A1 COL9A3 VPS33B	Abnormal hip bone morphology
KEGG:04510	0.00926542124788	0.3	COL9A2 COL4A2 COL9A3	Focal adhesion
HPA:0200000	0.0108224490549	0.2	COL9A2 COL9A3	eye
HP:0003365	0.0115420041928	0.2	COL9A2 COL9A3	Arthralgia of the hip
HP:0012769	0.0115420041928	0.2	COL9A2 COL9A3	Abnormal arm span
HP:0002644	0.014060289113	0.5	COL9A2 VIPAS39 COL13A1 COL9A3 VPS33B	Abnormal pelvic girdle bone morphology
HP:0009486	0.0148343034129	0.2	COL9A2 COL9A3	Radial deviation of the hand
HP:0006500	0.01488128731	0.3	PLOD3 COL9A3 COL9A2	Abnormal lower limb epiphysis morphology
KEGG:00514	0.0163216862479	0.2	PLOD3 COLGALT2	Other types of O-glycan biosynthesis
HP:0001884	0.0185361113698	0.2	VIPAS39 VPS33B	Talipes calcaneovalgus
HP:0012368	0.0302851626125	0.3	PLOD3 COL9A3 COL9A2	Flat face
HP:0010665	0.0320940919357	0.2	COL9A2 COL9A3	Bilateral coxa valga
HP:0030839	0.0320940919357	0.2	COL9A2 COL9A3	Knee pain
HP:0030973	0.0320940919357	0.2	COL9A2 COL9A3	Postexertional symptom exacerbation
KEGG:00310	0.0343628308557	0.2	PLOD3 COLGALT2	Lysine degradation
HP:0034430	0.034630199658	0.6	PLOD3 COL13A1 COL9A3 COL9A2 VPS33B VIPAS39	Abnormal joint physiology
HP:0011729	0.034630199658	0.6	PLOD3 COL13A1 COL9A3 COL9A2 VPS33B VIPAS39	Abnormality of joint mobility
KEGG:04151	0.0404637839965	0.3	COL9A2 COL4A2 COL9A3	PI3K-Akt signaling pathway
GO:0062023	0.0415014024807	0.5	COL9A2 COL4A2 COL13A1 COL9A3 COL21A1	collagen-containing extracellular matrix
HP:0000926	0.0420438188683	0.3	PLOD3 COL9A3 COL9A2	Platyspondyly
HP:0002515	0.0432410304082	0.3	COL9A2 COL13A1 COL9A3	Waddling gait
KEGG:05165	0.0438405134702	0.3	COL9A2 COL4A2 COL9A3	Human papillomavirus infection
HP:0006505	0.0444604573292	0.3	PLOD3 COL9A3 COL9A2	Abnormal limb epiphysis morphology
HP:0002804	0.0482539605636	0.3	VIPAS39 COL13A1 VPS33B	Arthrogryposis multiplex congenita
HP:0002611	0.0493214801054	0.2	VIPAS39 VPS33B	Cholestatic liver disease
HP:0100694	0.0493214801054	0.2	COL9A2 COL9A3	Tibial torsion

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
COLGALT2	PLOD3	0.998	0.088		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
VIPAS39	PLOD3	0.997	0.024		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
VPS33B	PLOD3	0.996	0.032	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
VPS33B	COLGALT2	0.995	0.06		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
COL13A1	COLGALT2	0.994			bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
COLGALT2	COL9A3	0.988			bioplex3_WMM bioplex3_HCT116 WMM_only
COLGALT2	COL9A2	0.984			bioplex3_WMM bioplex3_HCT116 WMM_only
COL9A2	PLOD3	0.982			bioplex3_WMM bioplex3_HCT116 WMM_only
COL4A2	COLGALT2	0.979	0.114		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
COL9A3	PLOD3	0.978			bioplex3_WMM bioplex3_HCT116 WMM_only
VIPAS39	COLGALT2	0.977	0.102		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
COL13A1	PLOD3	0.971			bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
COLGALT2	DOK1	0.959	0.11		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
COL21A1	PLOD3	0.957			bioplex3_HEK293 bioplex3_WMM WMM_only
VPS33B	VIPAS39	0.957	0.774	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
COL4A2	PLOD3	0.955	0.174		bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only
COLGALT2	COL21A1	0.925			bioplex3_HEK293 bioplex3_WMM WMM_only
COL4A2	COL21A1	0.896			bioplex3_HEK293 bioplex3_WMM WMM_only
VPS33B	COL9A2	0.633			bioplex3_WMM WMM_only
VIPAS39	COL9A3	0.633			bioplex3_WMM WMM_only
VIPAS39	COL13A1	0.633			bioplex3_WMM WMM_only
VPS33B	COL13A1	0.633			bioplex3_WMM WMM_only
VPS33B	COL9A3	0.633			bioplex3_WMM WMM_only
VIPAS39	COL9A2	0.633			bioplex3_WMM WMM_only
COL13A1	COL9A2	0.616			bioplex3_WMM WMM_only
COL9A2	COL9A3	0.616			bioplex3_WMM WMM_only
COL13A1	COL9A3	0.455			bioplex3_WMM WMM_only
COL4A2	COL13A1	0.326			bioplex_WMM bioplex3_WMM WMM_only
COL4A2	DOK1	0.22	0.076		bioplex_WMM bioplex3_WMM WMM_only
VIPAS39	COL4A2	0.219	0.012		bioplex_WMM bioplex3_WMM WMM_only
VPS33B	COL4A2	0.219	0.05		bioplex_WMM bioplex3_WMM WMM_only
DOK1	COL9A3	0.214			bioplex3_WMM WMM_only
DOK1	COL9A2	0.214			bioplex3_WMM WMM_only
VIPAS39	DOK1	0.172	0.164		bioplex_WMM bioplex3_WMM WMM_only
VPS33B	DOK1	0.15	0.124		bioplex_WMM bioplex3_WMM WMM_only
COL13A1	DOK1	0.146			bioplex3_WMM WMM_only
DOK1	PLOD3	0.075	0.074		bioplex_WMM bioplex3_WMM WMM_only
COL4A2	COL9A3	0.072			bioplex3_WMM WMM_only
COL4A2	COL9A2	0.046			bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
COL13A1	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_04420.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
COL21A1	huMAP3_02991.1 huMAP3_03726.1 huMAP3_05718.1 huMAP3_06974.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_13038.1
PLOD3	huMAP3_02991.1 huMAP3_03159.1 huMAP3_03726.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1
COLGALT2	huMAP3_00858.1 huMAP3_05924.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
DOK1	huMAP3_00858.1 huMAP3_00870.1 huMAP3_05924.1 huMAP3_08747.1 huMAP3_09119.1 huMAP3_10003.1 huMAP3_10500.1 huMAP3_13038.1 huMAP3_13345.1 huMAP3_14886.1 huMAP3_15305.1
VPS33B	huMAP3_00004.1 huMAP3_01906.1 huMAP3_06998.1 huMAP3_08196.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_15305.1
COL9A2	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
COL4A2	huMAP3_00257.1 huMAP3_00858.1 huMAP3_02991.1 huMAP3_04937.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10144.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
VIPAS39	huMAP3_00004.1 huMAP3_01906.1 huMAP3_06998.1 huMAP3_08196.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_15305.1
COL9A3	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10003.1

Complex Portal: CPX-17970