hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10007.1
Complex Portal: CPX-14116
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MBTPS2 | Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) | 5 | UniProt NCBI |
| DISP1 | Protein dispatched homolog 1 | 5 | UniProt NCBI |
| TMEM219 | Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) (Transmembrane protein 219) | 4 | UniProt NCBI |
| IL17RC | Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0100825 | 0.0329787201379 | 0.5 | IL17RC MBTPS2 | Cheilitis |
| WP:WP5256 | 0.049746753544 | 0.25 | IL17RC | COVID 19 and endothelial cell senescence |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MBTPS2 | IL17RC | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DISP1 | IL17RC | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IL17RC | TMEM219 | 0.955 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DISP1 | MBTPS2 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DISP1 | TMEM219 | 0.213 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MBTPS2 | TMEM219 | 0.165 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes