hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10021.1
Complex Portal: CPX-23979
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 5 | UniProt NCBI |
| VIRMA | Protein virilizer homolog | 5 | UniProt NCBI |
| CBLL1 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | 5 | UniProt NCBI |
| SPEN | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | 5 | UniProt NCBI |
| ZC3H13 | Zinc finger CCCH domain-containing protein 13 | 5 | UniProt NCBI |
| CBLL2 | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 2.76161616937e-08 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 2.81924903404e-07 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | mRNA editing complex |
| GO:0080009 | 9.38024124582e-07 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | mRNA methylation |
| GO:0016556 | 8.06004189332e-06 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | mRNA modification |
| CORUM:929 | 2.78560202173e-05 | 0.5 | WTAP ZC3H13 VIRMA | CEN complex |
| GO:0001510 | 0.000558442198281 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | RNA methylation |
| GO:0034708 | 0.00104484947805 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | methyltransferase complex |
| CORUM:351 | 0.00192068311585 | 0.5 | WTAP SPEN VIRMA | Spliceosome |
| GO:0043414 | 0.00415357355124 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | macromolecule methylation |
| GO:0032259 | 0.00484761913438 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | methylation |
| GO:0009451 | 0.00874812232885 | 0.666666666667 | ZC3H13 WTAP CBLL1 VIRMA | RNA modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WTAP | VIRMA | 1.0 | 0.606 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| CBLL2 | VIRMA | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WTAP | CBLL2 | 0.999 |
structurally_consistent (Q69YN4)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CBLL2 | ZC3H13 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| VIRMA | ZC3H13 | 0.999 | 0.294 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction | |
| WTAP | ZC3H13 | 0.995 | 0.242 | bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction | |
| CBLL1 | VIRMA | 0.987 | 0.1 |
structurally_consistent (dimer)
|
youn () youn_WMM Malo fraction |
| SPEN | VIRMA | 0.952 | 0.236 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| WTAP | SPEN | 0.891 | 0.252 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| WTAP | CBLL1 | 0.868 | 0.594 |
structurally_consistent (Q69YN4)
|
youn_WMM Malo fraction |
| CBLL1 | ZC3H13 | 0.423 | 0.286 | hein_WMM WMM_only | |
| SPEN | CBLL1 | 0.145 | 0.256 | youn_WMM WMM_only | |
| SPEN | ZC3H13 | 0.069 | 0.238 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes