hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10023.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SCO2 | Protein SCO2 homolog, mitochondrial | 5 | UniProt NCBI |
| HK2 | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | 5 | UniProt NCBI |
| NUBP2 | Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2) | 5 | UniProt NCBI |
| IRAK1 | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | 5 | UniProt NCBI |
| GART | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | 5 | UniProt NCBI |
| GGT7 | Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] | 5 | UniProt NCBI |
| HK3 | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00524 | 7.26621800375e-05 | 0.333333333333 | HK2 HK3 | Neomycin, kanamycin and gentamicin biosynthesis |
| KEGG:05230 | 9.43976951613e-05 | 0.5 | SCO2 HK3 HK2 | Central carbon metabolism in cancer |
| WP:WP5394 | 0.00045276091601 | 0.333333333333 | HK2 HK3 | UDP derived sugars synthesis in fibroblasts |
| KEGG:00500 | 0.0021719204592 | 0.333333333333 | HK2 HK3 | Starch and sucrose metabolism |
| KEGG:00052 | 0.00235248417572 | 0.333333333333 | HK2 HK3 | Galactose metabolism |
| KEGG:00051 | 0.00405482051627 | 0.333333333333 | HK2 HK3 | Fructose and mannose metabolism |
| KEGG:01250 | 0.00429978170568 | 0.333333333333 | HK2 HK3 | Biosynthesis of nucleotide sugars |
| KEGG:04973 | 0.00429978170568 | 0.333333333333 | HK2 HK3 | Carbohydrate digestion and absorption |
| KEGG:04930 | 0.00591925778494 | 0.333333333333 | HK2 HK3 | Type II diabetes mellitus |
| WP:WP500 | 0.00666790414994 | 0.333333333333 | HK2 HK3 | Glycogen synthesis and degradation |
| KEGG:00520 | 0.0071411999113 | 0.333333333333 | HK2 HK3 | Amino sugar and nucleotide sugar metabolism |
| WP:WP534 | 0.00861234767009 | 0.333333333333 | HK2 HK3 | Glycolysis and gluconeogenesis |
| KEGG:00010 | 0.0135980974704 | 0.333333333333 | HK2 HK3 | Glycolysis / Gluconeogenesis |
| REAC:R-HSA-1430728 | 0.0258573248266 | 0.833333333333 | SCO2 HK3 GGT7 NUBP2 HK2 | Metabolism |
| WP:WP4018 | 0.0275906315528 | 0.333333333333 | HK2 HK3 | Clear cell renal cell carcinoma pathways |
| KEGG:04066 | 0.034648047564 | 0.333333333333 | HK2 HK3 | HIF-1 signaling pathway |
| WP:WP5355 | 0.0362670507824 | 0.333333333333 | HK2 HK3 | Metabolic Epileptic Disorders |
| KEGG:01200 | 0.0382199966286 | 0.333333333333 | HK2 HK3 | Carbon metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HK3 | HK2 | 0.998 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NUBP2 | IRAK1 | 0.988 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| GART | IRAK1 | 0.979 | 0.136 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| GART | NUBP2 | 0.97 | 0.11 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| NUBP2 | HK2 | 0.962 | 0.04 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| NUBP2 | GGT7 | 0.962 | 0.07 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| IRAK1 | GGT7 | 0.96 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| IRAK1 | HK2 | 0.956 | 0.076 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| SCO2 | NUBP2 | 0.955 | 0.0500909090909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| HK2 | GGT7 | 0.84 | 0.0681013333333 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| GART | HK2 | 0.554 | 0.374 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM treiber_WMM |
| SCO2 | GGT7 | 0.12 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| SCO2 | IRAK1 | 0.085 | 0.1 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| SCO2 | HK2 | 0.061 | 0.076 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| GART | SCO2 | 0.046 | 0.156 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| GART | GGT7 | 0.041 | 0.0865588235294 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| HK3 | NUBP2 | 0.009 | 0.028 | bioplex3_WMM WMM_only |
| HK3 | GGT7 | 0.008 | 0.088 | bioplex3_WMM WMM_only |
| HK3 | IRAK1 | 0.007 | 0.056 | bioplex3_WMM WMM_only |
| HK3 | SCO2 | 0.004 | 0.034 | bioplex3_WMM WMM_only |
| GART | HK3 | 0.003 | 0.128558823529 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes