hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10025.1
Complex Portal: CPX-13779
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDUFB2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit) | 4 | UniProt NCBI |
| NDUFAF2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | 5 | UniProt NCBI |
| FAM185A | Protein FAM185A | 2 | UniProt NCBI |
| NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2) (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 9.14537722496e-06 | 0.75 | NDUFAF2 NDUFB2 NDUFV2 | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-6799198 | 4.09441910601e-05 | 0.75 | NDUFAF2 NDUFB2 NDUFV2 | Complex I biogenesis |
| REAC:R-HSA-611105 | 0.000219007946647 | 0.75 | NDUFAF2 NDUFB2 NDUFV2 | Respiratory electron transport |
| REAC:R-HSA-163200 | 0.000401649591062 | 0.75 | NDUFAF2 NDUFB2 NDUFV2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:04714 | 0.000480682574607 | 0.75 | NDUFAF2 NDUFB2 NDUFV2 | Thermogenesis |
| REAC:R-HSA-1428517 | 0.00109943198837 | 0.75 | NDUFAF2 NDUFB2 NDUFV2 | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP623 | 0.00434689671613 | 0.5 | NDUFB2 NDUFV2 | Oxidative phosphorylation |
| CORUM:178 | 0.00461173632066 | 0.5 | NDUFB2 NDUFV2 | Respiratory chain complex I (holoenzyme), mitochondrial |
| WP:WP111 | 0.0120322522645 | 0.5 | NDUFB2 NDUFV2 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:04723 | 0.017422762868 | 0.5 | NDUFB2 NDUFV2 | Retrograde endocannabinoid signaling |
| HP:0012748 | 0.0176079483787 | 0.5 | NDUFAF2 NDUFV2 | Focal T2 hyperintense brainstem lesion |
| KEGG:00190 | 0.0183110737362 | 0.5 | NDUFB2 NDUFV2 | Oxidative phosphorylation |
| HP:0007704 | 0.021003726131 | 0.5 | NDUFAF2 NDUFV2 | Paroxysmal involuntary eye movements |
| WP:WP4396 | 0.023499356813 | 0.5 | NDUFB2 NDUFV2 | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.0237566589162 | 0.5 | NDUFB2 NDUFV2 | Non-alcoholic fatty liver disease |
| HP:0008316 | 0.0246976114972 | 0.5 | NDUFAF2 NDUFV2 | Abnormal mitochondria in muscle tissue |
| HP:0012747 | 0.0246976114972 | 0.5 | NDUFAF2 NDUFV2 | Abnormal brainstem MRI signal intensity |
| HP:0000114 | 0.036003514982 | 0.5 | NDUFAF2 NDUFV2 | Proximal tubulopathy |
| KEGG:05415 | 0.0406374666322 | 0.5 | NDUFB2 NDUFV2 | Diabetic cardiomyopathy |
| HP:0003542 | 0.0441432413831 | 0.5 | NDUFAF2 NDUFV2 | Increased serum pyruvate |
| HP:0004366 | 0.0441432413831 | 0.5 | NDUFAF2 NDUFV2 | Abnormality of glycolysis |
| HP:0001138 | 0.0458701548093 | 0.5 | NDUFAF2 NDUFV2 | Optic neuropathy |
| HP:0003737 | 0.0476300363671 | 0.5 | NDUFAF2 NDUFV2 | Mitochondrial myopathy |
| KEGG:05208 | 0.049994875911 | 0.5 | NDUFB2 NDUFV2 | Chemical carcinogenesis - reactive oxygen species |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NDUFB2 | NDUFV2 | 0.979 | 0.828 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NDUFAF2 | NDUFV2 | 0.968 | 0.102 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only | |
| FAM185A | NDUFV2 | 0.952 | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NDUFB2 | FAM185A | 0.87 | 0.136 | bioplex3_WMM WMM_only | |
| NDUFAF2 | NDUFB2 | 0.864 | 0.178 | bioplex3_WMM WMM_only | |
| NDUFAF2 | FAM185A | 0.079 | 0.07 | bioplex3_WMM WMM_only |
Related Complexes