hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10028.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MBD5 | Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) | 5 | UniProt NCBI |
| BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | 5 | UniProt NCBI |
| ASXL1 | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | 5 | UniProt NCBI |
| ASXL2 | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | 5 | UniProt NCBI |
| NSD3 | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | 5 | UniProt NCBI |
| KDM1B | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5689603 | 9.19169655825e-09 | 0.833333333333 | KDM1B ASXL2 ASXL1 MBD5 BAP1 | UCH proteinases |
| KEGG:03083 | 6.74053506358e-07 | 0.666666666667 | ASXL2 ASXL1 MBD5 BAP1 | Polycomb repressive complex |
| REAC:R-HSA-5688426 | 1.50043747972e-06 | 0.833333333333 | KDM1B ASXL2 ASXL1 MBD5 BAP1 | Deubiquitination |
| GO:0035517 | 7.68841921772e-06 | 0.5 | ASXL2 BAP1 ASXL1 | PR-DUB complex |
| WP:WP5351 | 1.00378310922e-05 | 0.5 | ASXL1 MBD5 BAP1 | Kleefstra syndrome |
| HP:0000998 | 0.000838189674154 | 0.666666666667 | ASXL2 ASXL1 MBD5 BAP1 | Hypertrichosis |
| GO:0003682 | 0.00289552352997 | 0.833333333333 | KDM1B ASXL2 ASXL1 MBD5 BAP1 | chromatin binding |
| REAC:R-HSA-597592 | 0.00433380037126 | 0.833333333333 | KDM1B ASXL2 ASXL1 MBD5 BAP1 | Post-translational protein modification |
| HP:0003764 | 0.0132398709437 | 0.5 | ASXL2 BAP1 ASXL1 | Nevus |
| HP:0000664 | 0.0208218734023 | 0.5 | ASXL2 MBD5 ASXL1 | Synophrys |
| REAC:R-HSA-392499 | 0.0215959266916 | 0.833333333333 | KDM1B ASXL2 ASXL1 MBD5 BAP1 | Metabolism of proteins |
| GO:0031519 | 0.0219369042126 | 0.5 | ASXL2 BAP1 ASXL1 | PcG protein complex |
| HP:0002219 | 0.0252851538442 | 0.5 | ASXL2 MBD5 ASXL1 | Facial hypertrichosis |
| HP:0006191 | 0.0297012565438 | 0.333333333333 | ASXL2 ASXL1 | Deep palmar crease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ASXL2 | KDM1B | 0.999 | 0.226 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| ASXL2 | BAP1 | 0.998 | 0.292 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KDM1B | BAP1 | 0.997 | 0.328 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| BAP1 | ASXL1 | 0.995 | 0.15 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 |
| MBD5 | ASXL2 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NSD3 | KDM1B | 0.963 | 0.292 | hein_WMM hein () |
| KDM1B | ASXL1 | 0.944 | 0.18 | hein_WMM bioplex3_WMM WMM_only |
| ASXL2 | ASXL1 | 0.933 | 0.204 | bioplex3_WMM WMM_only |
| MBD5 | BAP1 | 0.889 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MBD5 | ASXL1 | 0.415 | bioplex3_WMM WMM_only | |
| MBD5 | KDM1B | 0.275 | bioplex_WMM bioplex3_WMM WMM_only | |
| ASXL2 | NSD3 | 0.138 | 0.098 | hein_WMM youn_WMM WMM_only |
| NSD3 | BAP1 | 0.087 | 0.402 | hein_WMM youn_WMM WMM_only |
Related Complexes