hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10032.1
Complex Portal: CPX-22739
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRTAP | Cartilage-associated protein | 5 | UniProt NCBI |
| P3H2 | Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4) | 5 | UniProt NCBI |
| P3H1 | Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) | 5 | UniProt NCBI |
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | 5 | UniProt NCBI |
| VPS37D | Vacuolar protein sorting-associated protein 37D (ESCRT-I complex subunit VPS37D) (Williams-Beuren syndrome chromosomal region 24 protein) | 5 | UniProt NCBI |
| CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | 5 | UniProt NCBI |
| EDA | Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form] | 5 | UniProt NCBI |
| PPIB | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | 5 | UniProt NCBI |
| TOR4A | Torsin-4A (Torsin family 4 member A) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4786 | 4.38357397504e-05 | 0.375 | P3H2 CRTAP P3H1 | Type I collagen synthesis in the context of osteogenesis imperfecta |
| CORUM:1769 | 7.17483486175e-05 | 0.25 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A complex |
| CORUM:1767 | 0.000143457417375 | 0.25 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1768 | 0.000239030245992 | 0.25 | NUDT21 CPSF6 | CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex |
| REAC:R-HSA-1650814 | 0.000499872649354 | 0.375 | P3H2 CRTAP P3H1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 0.00134205528321 | 0.375 | P3H2 CRTAP P3H1 | Collagen formation |
| HP:0008796 | 0.00135542525381 | 0.25 | P3H1 CRTAP | Femoral retroversion |
| HP:3000050 | 0.00185241136758 | 0.5 | P3H1 EDA CRTAP VPS37D | Abnormal odontoid tissue morphology |
| CORUM:1141 | 0.00186035657619 | 0.25 | NUDT21 CPSF6 | CF IIAm complex (Cleavage factor IIAm complex) |
| HP:0031069 | 0.0063183945919 | 0.25 | P3H1 CRTAP | Abnormal femoral torsion |
| HP:0011061 | 0.0103697625546 | 0.5 | P3H1 EDA CRTAP VPS37D | Abnormality of dental structure |
| HP:0005474 | 0.0306138099712 | 0.25 | P3H1 CRTAP | Decreased calvarial ossification |
| HP:0005855 | 0.0306138099712 | 0.25 | P3H1 CRTAP | Multiple prenatal fractures |
| HP:0000703 | 0.0344311064357 | 0.25 | P3H1 CRTAP | Dentinogenesis imperfecta |
| GO:1990120 | 0.0393180950424 | 0.25 | NUDT21 CPSF6 | messenger ribonucleoprotein complex assembly |
| GO:0019797 | 0.0393180950424 | 0.25 | P3H2 P3H1 | procollagen-proline 3-dioxygenase activity |
| REAC:R-HSA-1474244 | 0.0421371538836 | 0.375 | P3H2 CRTAP P3H1 | Extracellular matrix organization |
| HP:0010299 | 0.0427341718023 | 0.25 | P3H1 CRTAP | Abnormal dentin morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NUDT21 | CPSF6 | 1.0 | 0.892 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| CRTAP | P3H1 | 1.0 | 0.94 |
mutually_exclusive (Q8IVL5)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| CRTAP | P3H2 | 0.998 | 0.062 |
mutually_exclusive (Q32P28)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| P3H2 | P3H1 | 0.998 | 0.018 |
mutually_exclusive (O75718)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| EDA | PPIB | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EDA | P3H2 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| P3H1 | VPS37D | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NUDT21 | P3H1 | 0.983 | 0.05 | hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| CPSF6 | CRTAP | 0.977 | 0.094 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only | |
| EDA | CRTAP | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NUDT21 | P3H2 | 0.972 | 0.018 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CRTAP | VPS37D | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NUDT21 | CRTAP | 0.961 | 0.088 | hein_WMM bioplex_WMM bioplex3_WMM hein () treiber_WMM | |
| EDA | P3H1 | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TOR4A | P3H1 | 0.96 | 0.058 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPIB | VPS37D | 0.921 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PPIB | P3H1 | 0.917 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| CPSF6 | P3H2 | 0.759 | 0.022 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PPIB | CRTAP | 0.728 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| CPSF6 | P3H1 | 0.587 | 0.126 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| CRTAP | TOR4A | 0.473 | 0.096 | bioplex3_WMM WMM_only | |
| PPIB | P3H2 | 0.172 | 0.142 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPIB | CPSF6 | 0.115 | 0.242 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| EDA | TOR4A | 0.016 | bioplex3_WMM WMM_only | ||
| PPIB | TOR4A | 0.015 | 0.104 | bioplex3_WMM WMM_only | |
| NUDT21 | TOR4A | 0.004 | 0.042 | bioplex3_WMM WMM_only | |
| CPSF6 | TOR4A | 0.003 | 0.028 | bioplex3_WMM WMM_only | |
| NUDT21 | VPS37D | 0.003 | bioplex3_HEK293 bioplex () | ||
| EDA | CPSF6 | 0.003 | bioplex3_WMM WMM_only | ||
| EDA | NUDT21 | 0.002 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PPIB | NUDT21 | 0.001 | 0.146 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Related Complexes