hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10050.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DUS2 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) | 5 | UniProt NCBI |
| PHF20L1 | PHD finger protein 20-like protein 1 | 5 | UniProt NCBI |
| DDHD1 | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | 5 | UniProt NCBI |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | 5 | UniProt NCBI |
| KAT8 | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF) | 5 | UniProt NCBI |
| KANSL2 | KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) | 5 | UniProt NCBI |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2) | 3 | UniProt NCBI |
| MCRS1 | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | 5 | UniProt NCBI |
| PHF20 | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | 5 | UniProt NCBI |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | 5 | UniProt NCBI |
| C9JHY2 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044545 | 7.20228030652e-21 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | NSL complex |
| CORUM:7221 | 9.51606845968e-17 | 0.6 | PHF20 KANSL2 KANSL3 MCRS1 KANSL1 KAT8 | NSL complex |
| GO:1902562 | 5.13261546639e-15 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | H4 histone acetyltransferase complex |
| REAC:R-HSA-9772755 | 1.90368326509e-14 | 0.7 | PHF20 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL3 KAT8 | Formation of WDR5-containing histone-modifying complexes |
| GO:0000123 | 2.77946252441e-12 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | histone acetyltransferase complex |
| GO:1902493 | 6.79652069475e-12 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | acetyltransferase complex |
| GO:0031248 | 6.79652069475e-12 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | protein acetyltransferase complex |
| REAC:R-HSA-212165 | 7.46968105355e-10 | 0.7 | PHF20 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL3 KAT8 | Epigenetic regulation of gene expression |
| REAC:R-HSA-3214847 | 2.07298941859e-08 | 0.6 | PHF20 KANSL2 KANSL3 MCRS1 KANSL1 KAT8 | HATs acetylate histones |
| CORUM:5386 | 1.19727361794e-07 | 0.4 | MCRS1 KANSL1 KAT8 PHF20 | MLL1-WDR5 complex |
| REAC:R-HSA-4839726 | 1.13037097807e-06 | 0.6 | PHF20 KANSL2 KANSL3 MCRS1 KANSL1 KAT8 | Chromatin organization |
| REAC:R-HSA-3247509 | 1.13037097807e-06 | 0.6 | PHF20 KANSL2 KANSL3 MCRS1 KANSL1 KAT8 | Chromatin modifying enzymes |
| GO:1990234 | 0.000126088226089 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | transferase complex |
| GO:0071339 | 0.000172328178158 | 0.4 | MCRS1 KANSL1 KAT8 PHF20 | MLL1 complex |
| CORUM:610 | 0.000184411585051 | 0.2 | KAT8 KANSL1 | MSL complex |
| GO:0044665 | 0.000196881712788 | 0.4 | MCRS1 KANSL1 KAT8 PHF20 | MLL1/2 complex |
| GO:0140535 | 0.000198990526838 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | intracellular protein-containing complex |
| GO:0000785 | 0.000742884339789 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | chromatin |
| REAC:R-HSA-74160 | 0.000973001799799 | 0.7 | PHF20 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL3 KAT8 | Gene expression (Transcription) |
| GO:0032993 | 0.00118321437729 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | protein-DNA complex |
| GO:0035097 | 0.00344224325698 | 0.4 | MCRS1 KANSL1 KAT8 PHF20 | histone methyltransferase complex |
| GO:0005694 | 0.0129065863791 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | chromosome |
| GO:0034708 | 0.0143512934017 | 0.4 | MCRS1 KANSL1 KAT8 PHF20 | methyltransferase complex |
| GO:1902494 | 0.0260248958425 | 0.8 | KAT8 PHF20L1 KANSL2 KANSL1 MCRS1 KANSL1L KANSL3 PHF20 | catalytic complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHF20 | KANSL3 | 1.0 | 0.286 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHF20 | KANSL1 | 0.999 | 0.41 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHF20L1 | KANSL1 | 0.999 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KANSL2 | KANSL1 | 0.999 | 0.492 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KAT8 | KANSL3 | 0.998 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| MCRS1 | KANSL1 | 0.997 | 0.482 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHF20L1 | KANSL3 | 0.997 | 0.204 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHF20L1 | KAT8 | 0.997 | 0.146 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHF20L1 | MCRS1 | 0.997 | 0.314 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHF20L1 | KANSL2 | 0.997 | 0.164 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| KANSL2 | PHF20 | 0.995 | 0.316 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KANSL1 | DUS2 | 0.995 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KANSL1 | KAT8 | 0.994 | 0.192 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| MCRS1 | PHF20 | 0.992 | 0.374 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KANSL1 | KANSL3 | 0.991 | 0.348 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MCRS1 | KAT8 | 0.99 | 0.584 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| DDHD1 | KANSL2 | 0.99 | 0.144 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHF20 | KAT8 | 0.99 | 0.266 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MCRS1 | KANSL2 | 0.99 | 0.676 | bioplex_WMM Guru bioplex3_WMM fraction boldt_WMM | |
| KANSL2 | KANSL3 | 0.988 | 0.534 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| KANSL1L | PHF20L1 | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KANSL3 | C9JHY2 | 0.977 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| MCRS1 | KANSL3 | 0.954 | 0.332 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20L1 | C9JHY2 | 0.903 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KAT8 | C9JHY2 | 0.901 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KANSL1 | C9JHY2 | 0.897 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KANSL2 | C9JHY2 | 0.88 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MCRS1 | C9JHY2 | 0.841 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KANSL2 | KAT8 | 0.78 | 0.278 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20L1 | DUS2 | 0.572 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20 | DUS2 | 0.572 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| KANSL1L | KANSL3 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL1L | C9JHY2 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL1L | KANSL1 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL1L | KAT8 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL2 | DUS2 | 0.303 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20L1 | PHF20 | 0.265 | 0.236 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20 | C9JHY2 | 0.245 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KANSL1L | KANSL2 | 0.21 | bioplex3_WMM WMM_only | ||
| MCRS1 | DUS2 | 0.143 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| KANSL1L | MCRS1 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes