hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10051.1
Complex Portal: CPX-16189
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IRF2 | Interferon regulatory factor 2 (IRF-2) | 5 | UniProt NCBI |
| IRF2BPL | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | 5 | UniProt NCBI |
| TEAD3 | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | 5 | UniProt NCBI |
| CTSS | Cathepsin S (EC 3.4.22.27) | 5 | UniProt NCBI |
| IRF2BP1 | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | 5 | UniProt NCBI |
| IRF2BP2 | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | 5 | UniProt NCBI |
| VGLL4 | Transcription cofactor vestigial-like protein 4 (Vgl-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6848 | 2.80233355908e-09 | 0.6 | IRF2BPL IRF2BP2 IRF2BP1 | IRF2BP2-IRF2BP1-IRF2BPL complex |
| WP:WP4541 | 0.0264781270697 | 0.4 | TEAD3 VGLL4 | Hippo Merlin signaling dysregulation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IRF2BP1 | IRF2BP2 | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| IRF2BPL | IRF2BP1 | 1.0 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VGLL4 | TEAD3 | 1.0 | 0.066 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VGLL4 | IRF2BPL | 0.999 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IRF2BPL | IRF2BP2 | 0.999 | 0.074 | bioplex_WMM bioplex3_WMM Malo fraction | |
| VGLL4 | IRF2BP2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VGLL4 | IRF2BP1 | 0.999 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IRF2 | CTSS | 0.995 | 0.266 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRF2BPL | IRF2 | 0.995 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRF2BP2 | IRF2 | 0.993 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TEAD3 | IRF2BPL | 0.884 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only | |
| TEAD3 | IRF2BP1 | 0.878 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| TEAD3 | IRF2BP2 | 0.853 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP1 | IRF2 | 0.838 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRF2BPL | CTSS | 0.502 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP2 | CTSS | 0.35 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP1 | CTSS | 0.333 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes