hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10054.1
Complex Portal: CPX-25227
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FAAP20 | Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa) | 5 | UniProt NCBI |
| FANCG | Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9) | 5 | UniProt NCBI |
| POU2F2 | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | 5 | UniProt NCBI |
| FANCA | Fanconi anemia group A protein (Protein FACA) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6783310 | 9.16893973468e-06 | 0.75 | FANCA FAAP20 FANCG | Fanconi Anemia Pathway |
| CORUM:91 | 1.53774525569e-05 | 0.5 | FANCG FANCA | FA complex (Fanconi anemia complex), cytoplasmic |
| CORUM:3083 | 3.07520988333e-05 | 0.5 | FANCG FANCA | FA core complex 1 (Fanconi anemia core complex 1) |
| CORUM:1623 | 3.07520988333e-05 | 0.5 | FANCG FANCA | FA core complex 1 (Fanconi anemia core complex 1) |
| CORUM:1625 | 7.68662167609e-05 | 0.5 | FANCG FANCA | FA core complex (Fanconi anemia core complex) |
| GO:0043240 | 8.45465618902e-05 | 0.75 | FANCA FAAP20 FANCG | Fanconi anaemia nuclear complex |
| CORUM:1152 | 0.000107602882996 | 0.5 | FANCG FANCA | FA complex (Fanconi anemia complex) |
| CORUM:1624 | 0.000143457417375 | 0.5 | FANCG FANCA | FA core complex (Fanconi anemia core complex) |
| CORUM:245 | 0.000143457417375 | 0.5 | FANCG FANCA | FA core complex (Fanconi anemia core complex) |
| CORUM:6884 | 0.000184428417548 | 0.5 | FANCG FANCA | Fanconi anemia FAAP100 complex |
| CORUM:248 | 0.000184428417548 | 0.5 | FANCG FANCA | BRAFT complex |
| CORUM:2739 | 0.000230514481314 | 0.5 | FANCG FANCA | FA complex (Fanconi anemia complex) |
| CORUM:244 | 0.000281714206611 | 0.5 | FANCG FANCA | BRAFT complex |
| GO:0036297 | 0.00209449363787 | 0.75 | FANCA FAAP20 FANCG | interstrand cross-link repair |
| KEGG:03460 | 0.0029370300722 | 0.5 | FANCG FANCA | Fanconi anemia pathway |
| GO:0006513 | 0.00544401218013 | 0.75 | FANCA FAAP20 FANCG | protein monoubiquitination |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | FANCA FAAP20 FANCG | DNA Repair |
| HP:0005522 | 0.00771122114953 | 0.5 | FANCG FANCA | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 0.00844485194452 | 0.5 | FANCG FANCA | Absent testis |
| HP:0012848 | 0.0117117011059 | 0.5 | FANCG FANCA | Small intestinal stenosis |
| HP:0010293 | 0.0117117011059 | 0.5 | FANCG FANCA | Aplasia/Hypoplasia of the uvula |
| HP:0100867 | 0.0117117011059 | 0.5 | FANCG FANCA | Duodenal stenosis |
| HP:0002245 | 0.0126114492305 | 0.5 | FANCG FANCA | Meckel diverticulum |
| HP:0100760 | 0.0126114492305 | 0.5 | FANCG FANCA | Clubbing of toes |
| HP:0100587 | 0.0145105245688 | 0.5 | FANCG FANCA | Abnormal preputium morphology |
| WP:WP4946 | 0.0159973744593 | 0.5 | FANCG FANCA | DNA repair pathways full network |
| HP:0001924 | 0.0165423111708 | 0.5 | FANCG FANCA | Sideroblastic anemia |
| WP:WP5316 | 0.0208408229239 | 0.5 | FANCG FANCA | Primary ovarian insufficiency |
| HP:0001549 | 0.0222019103471 | 0.5 | FANCG FANCA | Abnormal ileum morphology |
| HP:0000813 | 0.0329787201379 | 0.5 | FANCG FANCA | Bicornuate uterus |
| HP:0007874 | 0.0375654511359 | 0.5 | FANCG FANCA | Almond-shaped palpebral fissure |
| HP:0100026 | 0.0391604009626 | 0.5 | FANCG FANCA | Arteriovenous malformation |
| HP:0003022 | 0.0424493051949 | 0.5 | FANCG FANCA | Hypoplasia of the ulna |
| HP:0003220 | 0.0441432413831 | 0.5 | FANCG FANCA | Abnormality of chromosome stability |
| HP:0200005 | 0.0458701548093 | 0.5 | FANCG FANCA | Abnormal shape of the palpebral fissure |
| HP:0006495 | 0.049422876951 | 0.5 | FANCG FANCA | Aplasia/Hypoplasia of the ulna |
| CORUM:3121 | 0.049938562206 | 0.25 | POU2F2 | OCT2-TLE4 complex |
| CORUM:3045 | 0.049938562206 | 0.25 | POU2F2 | hs4 enhancer complex (faster migrating complex) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FANCG | FANCA | 1.0 | 0.232 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FAAP20 | FANCA | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FAAP20 | FANCG | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| POU2F2 | FAAP20 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| POU2F2 | FANCG | 0.356 | 0.096 | bioplex3_WMM WMM_only | |
| POU2F2 | FANCA | 0.188 | 0.148 | bioplex3_WMM WMM_only |
Related Complexes