hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10060.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
WWOX	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1)	5	UniProt NCBI
LDLRAD3	Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3)	5	UniProt NCBI
CUEDC1	CUE domain-containing protein 1	3	UniProt NCBI
ILDR1	Immunoglobulin-like domain-containing receptor 1 (Angulin-2)	5	UniProt NCBI
NEDD4L	E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)	5	UniProt NCBI
FAIM2	Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2)	5	UniProt NCBI
RHBDD3	Rhomboid domain-containing protein 3	3	UniProt NCBI
NEDD4	E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)	5	UniProt NCBI
ARRDC3	Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)	5	UniProt NCBI
PRRG4	Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4)	5	UniProt NCBI
TMEM171	Transmembrane protein 171	3	UniProt NCBI
RNF168	E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)	5	UniProt NCBI
WBP1	WW domain-binding protein 1 (WBP-1)	3	UniProt NCBI
ITCH	E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)	5	UniProt NCBI
ENTREP3	Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1)	5	UniProt NCBI
HECW2	E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)	5	UniProt NCBI
STXBP4	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)	5	UniProt NCBI
WWP1	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)	5	UniProt NCBI
LDLRAD4	Low-density lipoprotein receptor class A domain-containing protein 4	5	UniProt NCBI
PRRG1	Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1)	4	UniProt NCBI
TMEM252	Transmembrane protein 252	2	UniProt NCBI
ARRDC1	Arrestin domain-containing protein 1 (Alpha-arrestin 1)	5	UniProt NCBI
HECW1	E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)	5	UniProt NCBI
TMEM51	Transmembrane protein 51	5	UniProt NCBI
NDFIP2	NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)	5	UniProt NCBI
ENTREP1	Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1253288	8.69541765825e-05	0.115384615385	NEDD4 WWP1 ITCH	Downregulation of ERBB4 signaling
REAC:R-HSA-1236394	0.000289480020853	0.153846153846	NEDD4 WWP1 WWOX ITCH	Signaling by ERBB4
GO:0016567	0.000448711616789	0.384615384615	ARRDC3 HECW2 ARRDC1 RNF168 ITCH HECW1 WWP1 NDFIP2 NEDD4 NEDD4L	protein ubiquitination
GO:0050699	0.00149739733317	0.153846153846	NDFIP2 PRRG4 WBP1 ENTREP3	WW domain binding
GO:0032446	0.00152687637723	0.384615384615	ARRDC3 HECW2 ARRDC1 RNF168 ITCH HECW1 WWP1 NDFIP2 NEDD4 NEDD4L	protein modification by small protein conjugation
GO:0070647	0.00387564495397	0.384615384615	ARRDC3 HECW2 ARRDC1 RNF168 ITCH HECW1 WWP1 NDFIP2 NEDD4 NEDD4L	protein modification by small protein conjugation or removal
GO:0043687	0.00716833267403	0.384615384615	ARRDC3 HECW2 ARRDC1 RNF168 ITCH HECW1 WWP1 NDFIP2 NEDD4 NEDD4L	post-translational protein modification
WP:WP4904	0.00778925814123	0.0769230769231	NEDD4 LDLRAD4	LDLRAD4 and what we know about it
GO:0061630	0.0115359576628	0.269230769231	HECW2 ITCH RNF168 HECW1 WWP1 NEDD4 NEDD4L	ubiquitin protein ligase activity
GO:0048814	0.0136762530452	0.153846153846	HECW1 NEDD4L HECW2 NEDD4	regulation of dendrite morphogenesis
GO:0061659	0.0173975475295	0.269230769231	HECW2 ITCH RNF168 HECW1 WWP1 NEDD4 NEDD4L	ubiquitin-like protein ligase activity
REAC:R-HSA-983168	0.0380508092685	0.192307692308	HECW2 NEDD4L WWP1 ITCH NEDD4	Antigen processing: Ubiquitination & Proteasome degradation

Edges

Protein 1	Protein 2	Score	ProteomeHD
ENTREP3	WWOX	0.999
NEDD4	ENTREP1	0.998
NEDD4	ILDR1	0.998
LDLRAD4	HECW2	0.998
ENTREP3	HECW2	0.997
NEDD4L	ILDR1	0.997
NEDD4	TMEM171	0.996
NEDD4	ENTREP3	0.996
HECW1	TMEM171	0.996
NEDD4L	ENTREP3	0.996
WWP1	CUEDC1	0.995	0.162
HECW1	LDLRAD4	0.995
ILDR1	HECW2	0.995
TMEM51	NEDD4	0.995
HECW1	ILDR1	0.995
NEDD4L	TMEM171	0.994
ENTREP1	HECW2	0.994
TMEM51	NEDD4L	0.994	0.104
CUEDC1	ITCH	0.993	0.086
HECW2	TMEM171	0.993
WWP1	ENTREP3	0.993
CUEDC1	STXBP4	0.992	0.118
NEDD4	PRRG1	0.992
NEDD4	LDLRAD4	0.992
NDFIP2	ITCH	0.991	0.064
HECW1	PRRG1	0.99
NEDD4	NEDD4L	0.99
STXBP4	TMEM171	0.99
PRRG1	HECW2	0.99
NEDD4	NDFIP2	0.989
ENTREP3	ITCH	0.989
ARRDC1	ITCH	0.989	0.094
CUEDC1	HECW2	0.988	0.118
TMEM252	STXBP4	0.988
TMEM171	ITCH	0.988
NEDD4L	PRRG1	0.987
WWP1	ARRDC3	0.986
NEDD4L	ENTREP1	0.985
TMEM51	ITCH	0.985	0.088
NEDD4	HECW2	0.985
CUEDC1	TMEM171	0.984
NEDD4L	STXBP4	0.983	0.09
WWP1	ITCH	0.982	0.152
WWP1	ENTREP1	0.982
LDLRAD4	ITCH	0.98
NEDD4	ARRDC1	0.98
TMEM51	WWP1	0.98	0.164
NEDD4	FAIM2	0.98
RHBDD3	ENTREP1	0.979
HECW1	ENTREP3	0.978
ARRDC3	ITCH	0.978
NEDD4L	LDLRAD4	0.977
PRRG4	NEDD4	0.977
ARRDC3	HECW2	0.974
ENTREP1	ITCH	0.972
RNF168	LDLRAD4	0.972
PRRG4	NEDD4L	0.97
WWP1	LDLRAD4	0.97
NEDD4L	TMEM252	0.969
ARRDC3	WWOX	0.969
NEDD4L	WWOX	0.969	0.226
WWP1	LDLRAD3	0.969
NEDD4	WBP1	0.967
ARRDC1	NEDD4L	0.967	0.116
RHBDD3	ENTREP3	0.966
NEDD4L	WBP1	0.966
NEDD4L	HECW2	0.966	0.192
HECW1	HECW2	0.964	0.202
PRRG4	STXBP4	0.958
WWOX	TMEM171	0.957
WBP1	ITCH	0.957
NEDD4	STXBP4	0.957
HECW1	NEDD4L	0.956	0.094
NEDD4L	NDFIP2	0.955	0.058
WWOX	WBP1	0.955
WWP1	NDFIP2	0.954	0.126
NEDD4	HECW1	0.953
NEDD4	ITCH	0.952
ENTREP1	STXBP4	0.95
WWP1	WBP1	0.95
ILDR1	ITCH	0.95
HECW2	WBP1	0.949
WWP1	HECW2	0.946	0.066
HECW2	ITCH	0.941	0.19
WWP1	NEDD4L	0.939	0.162
WWP1	STXBP4	0.938	0.158
WWP1	ARRDC1	0.937	0.19
ENTREP3	ENTREP1	0.937
WWP1	HECW1	0.924	0.102
CUEDC1	NEDD4	0.922
WWP1	ILDR1	0.919
NEDD4	TMEM252	0.918
TMEM51	CUEDC1	0.913	0.084
HECW1	ITCH	0.913	0.066
NEDD4L	ITCH	0.908	0.08
WWP1	NEDD4	0.905
WWP1	WWOX	0.884	0.104
ENTREP1	WWOX	0.871
CUEDC1	NEDD4L	0.863	0.106
LDLRAD4	STXBP4	0.856
PRRG1	STXBP4	0.8
HECW2	WWOX	0.789	0.11
WWP1	TMEM252	0.762
NEDD4L	ARRDC3	0.759
HECW2	STXBP4	0.706	0.196
NEDD4	ARRDC3	0.703
CUEDC1	ARRDC1	0.678	0.088
NEDD4	WWOX	0.667
WWP1	TMEM171	0.654
CUEDC1	ENTREP1	0.64
STXBP4	ITCH	0.608	0.14
HECW1	RNF168	0.53	0.1
WWOX	ITCH	0.473	0.172958333333
CUEDC1	ARRDC3	0.457
HECW1	STXBP4	0.454	0.076
ARRDC3	STXBP4	0.401
CUEDC1	LDLRAD4	0.399
CUEDC1	ENTREP3	0.34
WWP1	PRRG1	0.338
HECW1	WWOX	0.329
CUEDC1	WWOX	0.325	0.134
CUEDC1	HECW1	0.313	0.066
RNF168	HECW2	0.303	0.16
ARRDC1	HECW2	0.291	0.13
NDFIP2	WBP1	0.278
TMEM51	HECW2	0.253	0.094
RNF168	ITCH	0.239	0.162
PRRG4	ITCH	0.197
RHBDD3	HECW2	0.193
WWP1	RNF168	0.187	0.108
LDLRAD4	WWOX	0.177
RHBDD3	ITCH	0.171
ARRDC3	NDFIP2	0.168
ENTREP3	NDFIP2	0.158
RHBDD3	NEDD4L	0.146
WWP1	RHBDD3	0.146
NEDD4L	RNF168	0.143	0.09
RNF168	STXBP4	0.143	0.12
CUEDC1	RNF168	0.143	0.106
NEDD4	RNF168	0.143
PRRG1	ITCH	0.131
RHBDD3	CUEDC1	0.118
TMEM51	ARRDC1	0.113	0.104
NDFIP2	WWOX	0.112	0.108
TMEM51	RHBDD3	0.111
ARRDC1	PRRG1	0.11
HECW2	NDFIP2	0.106	0.066
LDLRAD3	ARRDC1	0.104
RHBDD3	NDFIP2	0.093
LDLRAD3	NDFIP2	0.081
NDFIP2	STXBP4	0.08	0.096
ARRDC1	NDFIP2	0.079	0.13
TMEM252	ITCH	0.071
RHBDD3	NEDD4	0.068
PRRG1	NDFIP2	0.067
CUEDC1	NDFIP2	0.067	0.086
ENTREP3	PRRG1	0.063
LDLRAD3	ENTREP3	0.063
LDLRAD3	ITCH	0.06
TMEM51	NDFIP2	0.058	0.134
WWOX	STXBP4	0.052	0.174
RHBDD3	HECW1	0.05
ARRDC1	ENTREP3	0.049
RHBDD3	WWOX	0.034
ENTREP3	STXBP4	0.028
RNF168	WWOX	0.027	0.104
RHBDD3	STXBP4	0.023
FAIM2	NEDD4L	0.022
ARRDC1	STXBP4	0.022	0.132
WWP1	FAIM2	0.02
PRRG4	WWP1	0.015
FAIM2	ITCH	0.012
TMEM51	WWOX	0.004	0.118

Related Complexes

Genename	Complexes
WWOX	huMAP3_05985.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10031.1 huMAP3_10060.1 huMAP3_11781.1
LDLRAD3	huMAP3_01285.1 huMAP3_02157.1 huMAP3_05856.1 huMAP3_07385.1 huMAP3_09701.1 huMAP3_09881.1 huMAP3_10060.1 huMAP3_10959.1 huMAP3_11781.1
CUEDC1	huMAP3_02377.1 huMAP3_06261.1 huMAP3_08343.1 huMAP3_08642.1 huMAP3_09367.1 huMAP3_09658.1 huMAP3_10060.1 huMAP3_11781.1 huMAP3_13216.1 huMAP3_13933.1 huMAP3_14916.1
ILDR1	huMAP3_04133.1 huMAP3_04262.1 huMAP3_06102.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
NEDD4L	huMAP3_02605.1 huMAP3_05985.1 huMAP3_06467.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
FAIM2	huMAP3_02412.1 huMAP3_06102.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
RHBDD3	huMAP3_01961.1 huMAP3_03745.1 huMAP3_04446.1 huMAP3_05412.1 huMAP3_07790.1 huMAP3_07866.1 huMAP3_07953.1 huMAP3_08356.1 huMAP3_08460.1 huMAP3_08939.1 huMAP3_08979.1 huMAP3_09484.1 huMAP3_10060.1
NEDD4	huMAP3_02412.1 huMAP3_06102.1 huMAP3_06467.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
ARRDC3	huMAP3_02793.1 huMAP3_09701.1 huMAP3_10031.1 huMAP3_10060.1 huMAP3_11781.1 huMAP3_13935.1
PRRG4	huMAP3_01111.1 huMAP3_02605.1 huMAP3_05985.1 huMAP3_07244.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
TMEM171	huMAP3_05985.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
RNF168	huMAP3_03094.1 huMAP3_10060.1 huMAP3_11389.1 huMAP3_11781.1
WBP1	huMAP3_05985.1 huMAP3_06467.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
ITCH	huMAP3_06102.1 huMAP3_07384.1 huMAP3_07385.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
ENTREP3	huMAP3_03146.1 huMAP3_04446.1 huMAP3_05985.1 huMAP3_06467.1 huMAP3_07567.1 huMAP3_07790.1 huMAP3_07953.1 huMAP3_09484.1 huMAP3_10060.1 huMAP3_15113.1 huMAP3_15126.1
HECW2	huMAP3_04262.1 huMAP3_06102.1 huMAP3_06467.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
STXBP4	huMAP3_05985.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
WWP1	huMAP3_01285.1 huMAP3_02157.1 huMAP3_05856.1 huMAP3_06294.1 huMAP3_06752.1 huMAP3_07385.1 huMAP3_09701.1 huMAP3_09881.1 huMAP3_10060.1 huMAP3_10959.1 huMAP3_11781.1
LDLRAD4	huMAP3_03094.1 huMAP3_06467.1 huMAP3_06903.1 huMAP3_10060.1 huMAP3_11389.1 huMAP3_11781.1
PRRG1	huMAP3_04262.1 huMAP3_06102.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
TMEM252	huMAP3_02786.1 huMAP3_05985.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11416.1 huMAP3_11781.1
ARRDC1	huMAP3_02412.1 huMAP3_06102.1 huMAP3_06903.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_09521.1 huMAP3_10060.1 huMAP3_11781.1
HECW1	huMAP3_02412.1 huMAP3_06102.1 huMAP3_06903.1 huMAP3_07815.1 huMAP3_08343.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_11781.1
TMEM51	huMAP3_01096.1 huMAP3_05856.1 huMAP3_07604.1 huMAP3_08822.1 huMAP3_09663.1 huMAP3_09701.1 huMAP3_09881.1 huMAP3_10060.1 huMAP3_10246.1 huMAP3_10959.1 huMAP3_11781.1
NDFIP2	huMAP3_05453.1 huMAP3_06102.1 huMAP3_06467.1 huMAP3_07384.1 huMAP3_09367.1 huMAP3_10060.1 huMAP3_10136.1 huMAP3_11605.1
ENTREP1	huMAP3_03745.1 huMAP3_07385.1 huMAP3_07953.1 huMAP3_08939.1 huMAP3_09484.1 huMAP3_10060.1 huMAP3_11781.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10060.1