hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10063.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBL5 | Ubiquitin-like protein 5 | 5 | UniProt NCBI |
| WBP11 | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | 5 | UniProt NCBI |
| MFAP1 | Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) | 5 | UniProt NCBI |
| PRPF38A | Pre-mRNA-splicing factor 38A | 5 | UniProt NCBI |
| PQBP1 | Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72163 | 7.60208852298e-08 | 1.0 | UBL5 PRPF38A PQBP1 WBP11 MFAP1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 9.03664675283e-08 | 1.0 | UBL5 PRPF38A PQBP1 WBP11 MFAP1 | mRNA Splicing |
| REAC:R-HSA-72203 | 3.62691640182e-07 | 1.0 | UBL5 PRPF38A PQBP1 WBP11 MFAP1 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-8953854 | 3.59450904867e-05 | 1.0 | UBL5 PRPF38A PQBP1 WBP11 MFAP1 | Metabolism of RNA |
| KEGG:03040 | 0.0002928242891 | 0.6 | PRPF38A WBP11 PQBP1 | Spliceosome |
| GO:0000377 | 0.0264444778619 | 0.8 | UBL5 PQBP1 MFAP1 PRPF38A | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.0264444778619 | 0.8 | UBL5 PQBP1 MFAP1 PRPF38A | mRNA splicing, via spliceosome |
| GO:0000375 | 0.0280745884658 | 0.8 | UBL5 PQBP1 MFAP1 PRPF38A | RNA splicing, via transesterification reactions |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WBP11 | PQBP1 | 1.0 | 0.868 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| PRPF38A | MFAP1 | 1.0 | 0.858 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| PQBP1 | MFAP1 | 0.994 | 0.912 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| WBP11 | MFAP1 | 0.983 | 0.958 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| UBL5 | PQBP1 | 0.969 | 0.068 | hein_WMM youn_WMM hein () |
| WBP11 | UBL5 | 0.515 | 0.028 | hein_WMM youn_WMM WMM_only |
| UBL5 | MFAP1 | 0.459 | 0.26 | hein_WMM youn_WMM WMM_only |
| PRPF38A | PQBP1 | 0.356 | 0.14 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| WBP11 | PRPF38A | 0.121 | 0.41 | bioplex3_WMM youn_WMM gupta_WMM fraction |
| PRPF38A | UBL5 | 0.008 | 0.07 | youn_WMM WMM_only |
Related Complexes