hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10066.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PLEKHN1	Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)	5	UniProt NCBI
ELP2	Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1)	5	UniProt NCBI
ELP3	Elongator complex protein 3 (hELP3) (EC 2.3.1.-) (tRNA uridine(34) acetyltransferase)	5	UniProt NCBI
DPH2	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)	5	UniProt NCBI
ELP1	Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150)	5	UniProt NCBI
DPH1	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (Ovarian cancer-associated gene 1 protein) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)	5	UniProt NCBI
FAM219B	Protein FAM219B	3	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2716	7.02338504734e-09	0.428571428571	ELP1 ELP2 ELP3	Elongator core complex
CORUM:1380	2.80877722849e-08	0.428571428571	ELP1 ELP2 ELP3	Elongator holo complex
CORUM:6332	1.4038119659e-07	0.428571428571	ELP1 ELP2 ELP3	Elongator complex (ELP1, ELP2, ELP3, ELP4, ELP5, ELP6)
GO:0033588	6.72425931667e-05	0.428571428571	ELP1 ELP2 ELP3	elongator holoenzyme complex
REAC:R-HSA-5358493	0.000799384186586	0.285714285714	DPH2 DPH1	Synthesis of diphthamide-EEF2
GO:0002098	0.00228108846854	0.428571428571	ELP1 ELP2 ELP3	tRNA wobble uridine modification
HP:0012712	0.00349561220575	0.285714285714	DPH2 DPH1	Mild hearing impairment
GO:0002097	0.00382182132582	0.428571428571	ELP1 ELP2 ELP3	tRNA wobble base modification
REAC:R-HSA-3214847	0.00444068087029	0.428571428571	ELP1 ELP2 ELP3	HATs acetylate histones
GO:0090560	0.00983221512175	0.285714285714	DPH2 DPH1	2-(3-amino-3-carboxypropyl)histidine synthase activity
HP:0007291	0.0199339480346	0.285714285714	DPH2 DPH1	Posterior fossa cyst
REAC:R-HSA-163841	0.0251789059	0.285714285714	DPH2 DPH1	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
GO:0002926	0.0294899169624	0.285714285714	ELP1 ELP3	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
HP:0004442	0.0315332858987	0.285714285714	DPH2 DPH1	Sagittal craniosynostosis
REAC:R-HSA-4839726	0.0318833774227	0.428571428571	ELP1 ELP2 ELP3	Chromatin organization
REAC:R-HSA-3247509	0.0318833774227	0.428571428571	ELP1 ELP2 ELP3	Chromatin modifying enzymes
HP:0001970	0.0348446257606	0.285714285714	DPH2 DPH1	Tubulointerstitial nephritis
HP:0000805	0.0419603197237	0.285714285714	DPH2 DPH1	Enuresis

Protein 1	Protein 2	Score	ProteomeHD	Evidence
ELP2	ELP3	1.0	0.576	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
ELP1	ELP3	1.0	0.592	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM
ELP2	ELP1	0.999	0.608	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo fraction boldt_WMM
ELP2	FAM219B	0.998	0.094	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
DPH2	FAM219B	0.995	0.09	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ELP3	FAM219B	0.993	0.09	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
DPH2	DPH1	0.99	0.382	bioplex_WMM Guru bioplex3_WMM fraction
FAM219B	DPH1	0.99	0.082	bioplex3_WMM bioplex3_HCT116 WMM_only
PLEKHN1	ELP3	0.984		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ELP1	FAM219B	0.972	0.05	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ELP3	DPH1	0.885	0.216	bioplex_WMM bioplex3_WMM WMM_only
ELP1	PLEKHN1	0.806		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ELP2	DPH2	0.722	0.184	bioplex_WMM bioplex3_WMM WMM_only
ELP2	DPH1	0.602	0.262	bioplex_WMM bioplex3_WMM WMM_only
ELP1	DPH1	0.464	0.33	bioplex_WMM bioplex3_WMM WMM_only
ELP2	PLEKHN1	0.392		bioplex3_HEK293 bioplex3_WMM WMM_only
ELP3	DPH2	0.244	0.138	bioplex_WMM bioplex3_WMM WMM_only
ELP1	DPH2	0.208	0.134	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PLEKHN1	huMAP3_00156.1 huMAP3_00699.1 huMAP3_00925.1 huMAP3_03857.1 huMAP3_05863.1 huMAP3_06817.1 huMAP3_07900.1 huMAP3_08203.1 huMAP3_08256.1 huMAP3_10066.1 huMAP3_10509.1 huMAP3_10779.1 huMAP3_12018.1 huMAP3_12659.1 huMAP3_12672.1 huMAP3_13683.1 huMAP3_15011.1
ELP2	huMAP3_00156.1 huMAP3_00925.1 huMAP3_03857.1 huMAP3_05863.1 huMAP3_06545.1 huMAP3_07900.1 huMAP3_08256.1 huMAP3_10066.1 huMAP3_10779.1 huMAP3_12672.1
ELP3	huMAP3_00156.1 huMAP3_00925.1 huMAP3_03857.1 huMAP3_05863.1 huMAP3_06817.1 huMAP3_07900.1 huMAP3_08256.1 huMAP3_10066.1 huMAP3_10779.1 huMAP3_12672.1 huMAP3_13683.1
DPH2	huMAP3_00369.1 huMAP3_05866.1 huMAP3_07390.1 huMAP3_09661.1 huMAP3_10066.1 huMAP3_10779.1 huMAP3_13227.1 huMAP3_14168.1 huMAP3_14723.1
ELP1	huMAP3_00156.1 huMAP3_00478.1 huMAP3_05671.1 huMAP3_05863.1 huMAP3_06545.1 huMAP3_07900.1 huMAP3_08256.1 huMAP3_08475.1 huMAP3_10066.1 huMAP3_10201.1 huMAP3_10779.1 huMAP3_12672.1
DPH1	huMAP3_01905.1 huMAP3_07390.1 huMAP3_08394.1 huMAP3_09661.1 huMAP3_10066.1 huMAP3_10779.1 huMAP3_14849.1
FAM219B	huMAP3_00369.1 huMAP3_00925.1 huMAP3_01905.1 huMAP3_07900.1 huMAP3_08256.1 huMAP3_09661.1 huMAP3_10066.1 huMAP3_10779.1 huMAP3_12672.1