hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10071.1

Complex Portal: CPX-21368

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
DDOST	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit)	5	UniProt NCBI
RPN1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)	5	UniProt NCBI
DAD1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (Defender against cell death 1) (DAD-1)	5	UniProt NCBI
MAGT1	Magnesium transporter protein 1 (MagT1) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1) (Oligosaccharyl transferase subunit MAGT1) (Implantation-associated protein) (IAP)	5	UniProt NCBI
STT3B	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog)	5	UniProt NCBI
LMF2	Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153)	4	UniProt NCBI
TUSC3	Tumor suppressor candidate 3 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3) (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33)	5	UniProt NCBI
TMEM258	Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258)	5	UniProt NCBI
CLGN	Calmegin	5	UniProt NCBI
RPN2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1200	3.1040134829e-22	0.7	STT3B RPN2 TUSC3 RPN1 MAGT1 DDOST DAD1	Oligosaccharyltransferase complex (Stt3B variant)
GO:0008250	7.20228030652e-21	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	oligosaccharyltransferase complex
KEGG:00513	3.36864399652e-18	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	Various types of N-glycan biosynthesis
KEGG:00510	1.65128384184e-17	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	N-Glycan biosynthesis
CORUM:1199	1.98697170849e-14	0.5	DDOST MAGT1 RPN2 RPN1 DAD1	Oligosaccharyltransferase complex (Stt3A variant)
GO:0018279	3.61642463957e-14	0.7	STT3B RPN2 TUSC3 RPN1 MAGT1 DDOST DAD1	protein N-linked glycosylation via asparagine
GO:0006487	1.11019088612e-13	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	protein N-linked glycosylation
KEGG:04141	3.13028128503e-13	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	Protein processing in endoplasmic reticulum
REAC:R-HSA-9694548	6.04793658812e-12	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Maturation of spike protein
GO:0140534	1.20316323547e-11	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	endoplasmic reticulum protein-containing complex
WP:WP5153	2.72407438898e-11	0.6	STT3B RPN2 TUSC3 RPN1 DDOST DAD1	N glycan biosynthesis
REAC:R-HSA-9694635	8.51787906811e-11	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Translation of Structural Proteins
REAC:R-HSA-9772573	2.27605309718e-10	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Late SARS-CoV-2 Infection Events
GO:0006486	3.10836931604e-10	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	protein glycosylation
GO:0043413	3.10836931604e-10	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	macromolecule glycosylation
GO:0070085	7.93514856437e-10	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	glycosylation
GO:0005789	3.11850675078e-09	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	endoplasmic reticulum membrane
GO:0098827	3.64592484152e-09	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	endoplasmic reticulum subcompartment
GO:0042175	3.96625551604e-09	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	nuclear outer membrane-endoplasmic reticulum membrane network
GO:0009101	6.33112302651e-09	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	glycoprotein biosynthetic process
GO:0009100	3.09336699532e-08	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	glycoprotein metabolic process
GO:0031984	5.79077579384e-08	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	organelle subcompartment
REAC:R-HSA-9694516	1.91604477751e-06	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	SARS-CoV-2 Infection
CORUM:6131	2.01554870026e-06	0.3	DDOST RPN1 RPN2	SELK multiprotein complex
REAC:R-HSA-446203	2.37666556341e-06	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Asparagine N-linked glycosylation
GO:0005783	2.77476326542e-06	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	endoplasmic reticulum
GO:1901137	3.14992219523e-06	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	carbohydrate derivative biosynthetic process
REAC:R-HSA-9679506	1.29563983263e-05	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	SARS-CoV Infections
GO:0004579	0.000115261178119	0.3	RPN2 RPN1 STT3B	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:1990234	0.000126088226089	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	transferase complex
GO:1901135	0.000143834007089	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	carbohydrate derivative metabolic process
GO:0004576	0.0002304395259	0.3	RPN2 RPN1 STT3B	oligosaccharyl transferase activity
GO:0098796	0.000493494055761	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	membrane protein complex
REAC:R-HSA-9824446	0.000521039877845	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Viral Infection Pathways
GO:0031090	0.000959229479862	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	organelle membrane
REAC:R-HSA-5663205	0.00173306517432	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Infectious disease
HP:0012345	0.00384895569799	0.3	DDOST STT3B MAGT1	Abnormal glycosylation
GO:1901566	0.00657911349355	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	organonitrogen compound biosynthetic process
WP:WP4521	0.0104129071256	0.2	MAGT1 TUSC3	Glycosylation and related congenital defects
REAC:R-HSA-1799339	0.011571513111	0.3	DDOST RPN1 RPN2	SRP-dependent cotranslational protein targeting to membrane
REAC:R-HSA-597592	0.0133621598082	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Post-translational protein modification
GO:0012505	0.018998349123	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	endomembrane system
REAC:R-HSA-5223345	0.0192120670931	0.2	MAGT1 TUSC3	Miscellaneous transport and binding events
GO:0034998	0.0210690324038	0.2	TMEM258 STT3B	oligosaccharyltransferase I complex
GO:1902494	0.0260248958425	0.8	STT3B RPN2 TUSC3 RPN1 MAGT1 TMEM258 DDOST DAD1	catalytic complex
GO:0019538	0.0262140069754	1.0	RPN2 STT3B LMF2 RPN1 TUSC3 MAGT1 TMEM258 DDOST DAD1 CLGN	protein metabolic process
REAC:R-HSA-1643685	0.0385148593027	0.6	RPN2 RPN1 TUSC3 MAGT1 DDOST DAD1	Disease
KEGG:01100	0.0473829926773	0.5	DDOST RPN2 RPN1 STT3B DAD1	Metabolic pathways

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
RPN2	RPN1	1.0	0.98		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
MAGT1	STT3B	0.999	0.826	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
RPN2	STT3B	0.999	0.87		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
RPN2	DDOST	0.999	0.984		bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
DDOST	STT3B	0.998	0.906	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
RPN2	MAGT1	0.997	0.652		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM
DDOST	MAGT1	0.997	0.596	structurally_consistent (Q8TCJ2)	bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
DDOST	RPN1	0.997	0.978	structurally_consistent (Q8TCJ2)	hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RPN1	CLGN	0.996	0.074		bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
STT3B	CLGN	0.991	0.082		bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only
RPN1	STT3B	0.99	0.792	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
MAGT1	CLGN	0.99	0.054		bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only
TMEM258	RPN2	0.987	0.792		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DAD1	STT3B	0.977	0.83	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
DAD1	TUSC3	0.973		structurally_consistent (Q8TCJ2)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPN2	DAD1	0.971	0.934		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM
RPN1	MAGT1	0.97	0.532	structurally_consistent (Q8TCJ2)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only
STT3B	TUSC3	0.969		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RPN2	CLGN	0.965	0.11		bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
STT3B	LMF2	0.961	0.194		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
TMEM258	TUSC3	0.936			bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TMEM258	RPN1	0.921	0.748		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
DDOST	CLGN	0.906	0.182		bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
RPN2	TUSC3	0.9			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
DAD1	MAGT1	0.853	0.386	structurally_consistent (Q8TCJ2)	bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
RPN1	DAD1	0.838	0.794	structurally_consistent (Q8TCJ2)	bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
TMEM258	DDOST	0.832	0.852		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
TMEM258	STT3B	0.823	0.75		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
RPN1	TUSC3	0.718		structurally_consistent (Q8TCJ2)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
DDOST	TUSC3	0.661		structurally_consistent (Q8TCJ2)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MAGT1	TUSC3	0.607		mutually_exclusive (Q8TCJ2)	bioplex_WMM bioplex3_WMM WMM_only
TMEM258	DAD1	0.528	0.684		bioplex_WMM bioplex3_WMM WMM_only
LMF2	CLGN	0.456	0.068		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
MAGT1	LMF2	0.446	0.092		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
TMEM258	MAGT1	0.438	0.312		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
LMF2	TUSC3	0.288			bioplex_WMM bioplex3_WMM WMM_only
DAD1	CLGN	0.217	0.094		bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
DDOST	DAD1	0.155	0.948		bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
RPN1	LMF2	0.12	0.32		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
RPN2	LMF2	0.087	0.286		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DDOST	LMF2	0.076	0.272		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CLGN	TUSC3	0.046			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DAD1	LMF2	0.037	0.196		bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
TMEM258	CLGN	0.023	0.0243333333333		bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
DDOST	huMAP3_00921.1 huMAP3_05358.1 huMAP3_05375.1 huMAP3_06187.1 huMAP3_06663.1 huMAP3_07211.1 huMAP3_08559.1 huMAP3_08612.1 huMAP3_09763.1 huMAP3_09893.1 huMAP3_10071.1
RPN1	huMAP3_00921.1 huMAP3_06187.1 huMAP3_06877.1 huMAP3_07211.1 huMAP3_08167.1 huMAP3_09332.1 huMAP3_09592.1 huMAP3_10071.1 huMAP3_10473.1
DAD1	huMAP3_00921.1 huMAP3_01189.1 huMAP3_07211.1 huMAP3_08612.1 huMAP3_09893.1 huMAP3_10071.1
MAGT1	huMAP3_00921.1 huMAP3_05375.1 huMAP3_06187.1 huMAP3_07211.1 huMAP3_10071.1
STT3B	huMAP3_00921.1 huMAP3_07211.1 huMAP3_08612.1 huMAP3_09893.1 huMAP3_10071.1
LMF2	huMAP3_00921.1 huMAP3_01077.1 huMAP3_04961.1 huMAP3_07211.1 huMAP3_07511.1 huMAP3_08190.1 huMAP3_08252.1 huMAP3_08612.1 huMAP3_08753.1 huMAP3_09396.1 huMAP3_09893.1 huMAP3_10071.1 huMAP3_10532.1 huMAP3_11420.1 huMAP3_14700.1 huMAP3_15126.1
TUSC3	huMAP3_01189.1 huMAP3_09893.1 huMAP3_10071.1 huMAP3_11420.1 huMAP3_14700.1 huMAP3_15126.1
TMEM258	huMAP3_00538.1 huMAP3_00994.1 huMAP3_01801.1 huMAP3_02840.1 huMAP3_07451.1 huMAP3_09736.1 huMAP3_10071.1 huMAP3_13070.1
CLGN	huMAP3_00921.1 huMAP3_07211.1 huMAP3_07693.1 huMAP3_09514.1 huMAP3_10071.1 huMAP3_14123.1
RPN2	huMAP3_00538.1 huMAP3_06247.1 huMAP3_07410.1 huMAP3_08952.1 huMAP3_09592.1 huMAP3_10071.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10071.1

Complex Portal: CPX-21368