hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10080.1
Complex Portal: CPX-23479
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RFLNB | Refilin-B (Regulator of filamin protein B) (RefilinB) | 3 | UniProt NCBI |
| SKA2 | Spindle and kinetochore-associated protein 2 (Protein FAM33A) | 5 | UniProt NCBI |
| SKA3 | Spindle and kinetochore-associated protein 3 | 5 | UniProt NCBI |
| NUDT5 | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | 5 | UniProt NCBI |
| PPAT | Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) | 5 | UniProt NCBI |
| SKA1 | Spindle and kinetochore-associated protein 1 | 5 | UniProt NCBI |
| AGBL2 | Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000940 | 0.00382182132582 | 0.428571428571 | SKA2 SKA3 SKA1 | outer kinetochore |
| GO:0051315 | 0.00677983410628 | 0.428571428571 | SKA2 SKA3 SKA1 | attachment of mitotic spindle microtubules to kinetochore |
| KEGG:00230 | 0.047723469919 | 0.285714285714 | NUDT5 PPAT | Purine metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SKA1 | SKA2 | 1.0 | 0.302 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| SKA3 | SKA2 | 1.0 | 0.446 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | |
| SKA1 | SKA3 | 1.0 | 0.636 |
mutually_exclusive (Q00005)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| AGBL2 | NUDT5 | 0.999 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| SKA1 | NUDT5 | 0.992 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| NUDT5 | PPAT | 0.991 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| RFLNB | NUDT5 | 0.988 | 0.048 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| SKA3 | NUDT5 | 0.951 | 0.092 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| RFLNB | AGBL2 | 0.939 | bioplex3_WMM WMM_only | ||
| SKA2 | NUDT5 | 0.725 | 0.12 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| AGBL2 | PPAT | 0.624 | bioplex3_WMM WMM_only | ||
| RFLNB | PPAT | 0.151 | 0.028 | bioplex3_WMM youn_WMM WMM_only | |
| RFLNB | SKA3 | 0.018 | 0.066 | bioplex3_WMM youn_WMM WMM_only | |
| RFLNB | SKA1 | 0.018 | 0.114 | youn_WMM WMM_only | |
| RFLNB | SKA2 | 0.012 | 0.158 | youn_WMM WMM_only | |
| SKA3 | PPAT | 0.007 | 0.104 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| SKA1 | PPAT | 0.005 | 0.106 | youn_WMM WMM_only | |
| SKA2 | PPAT | 0.003 | 0.098 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes