hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10095.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
COL5A2	Collagen alpha-2(V) chain	5	UniProt NCBI
COL17A1	Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)]	5	UniProt NCBI
COL6A3	Collagen alpha-3(VI) chain	5	UniProt NCBI
COL4A4	Collagen alpha-4(IV) chain	5	UniProt NCBI
LAIR2	Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306)	4	UniProt NCBI
CCBE1	Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog)	5	UniProt NCBI
PRSS23	Serine protease 23 (EC 3.4.21.-) (Putative secreted protein Zsig13)	4	UniProt NCBI
COL5A1	Collagen alpha-1(V) chain	5	UniProt NCBI
COL26A1	Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8948216	3.04472750109e-10	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	Collagen chain trimerization
REAC:R-HSA-1442490	4.06092407624e-09	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	Collagen degradation
REAC:R-HSA-1650814	5.5319301391e-09	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	Collagen biosynthesis and modifying enzymes
KEGG:04974	5.54964532405e-09	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	Protein digestion and absorption
REAC:R-HSA-1474290	2.96791723199e-08	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	Collagen formation
REAC:R-HSA-1474228	2.03667962981e-07	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	Degradation of the extracellular matrix
REAC:R-HSA-2022090	1.38487166109e-06	0.5	COL5A1 COL17A1 COL5A2 COL4A4	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-1474244	1.01442440227e-05	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	Extracellular matrix organization
GO:0005788	2.98553722179e-05	0.75	COL26A1 PRSS23 COL5A1 COL5A2 COL17A1 COL4A4	endoplasmic reticulum lumen
GO:0030020	4.35075554541e-05	0.5	COL5A1 COL17A1 COL5A2 COL4A4	extracellular matrix structural constituent conferring tensile strength
REAC:R-HSA-419037	6.65860913492e-05	0.375	COL5A1 COL5A2 COL4A4	NCAM1 interactions
REAC:R-HSA-375165	0.000260330782854	0.375	COL5A1 COL5A2 COL4A4	NCAM signaling for neurite out-growth
GO:0030312	0.000333811381799	0.75	COL26A1 COL5A1 CCBE1 COL17A1 COL4A4 COL5A2	external encapsulating structure
GO:0031012	0.000333811381799	0.75	COL26A1 COL5A1 CCBE1 COL17A1 COL4A4 COL5A2	extracellular matrix
REAC:R-HSA-186797	0.000391615111842	0.375	COL5A1 COL5A2 COL4A4	Signaling by PDGF
REAC:R-HSA-3000171	0.000391615111842	0.375	COL5A1 COL5A2 COL4A4	Non-integrin membrane-ECM interactions
HP:0001030	0.00041417216178	0.375	COL17A1 COL5A2 COL5A1	Fragile skin
HP:0001075	0.000502461035825	0.375	COL17A1 COL5A2 COL5A1	Atrophic scars
HP:0025014	0.000677898190386	0.25	COL5A1 COL5A2	Subcutaneous spheroids
HP:0025509	0.000677898190386	0.25	COL5A1 COL5A2	Piezogenic pedal papules
REAC:R-HSA-3000178	0.000696845667831	0.375	COL5A1 COL5A2 COL4A4	ECM proteoglycans
REAC:R-HSA-216083	0.00089567252269	0.375	COL5A1 COL5A2 COL4A4	Integrin cell surface interactions
HP:0030009	0.00135542525381	0.25	COL5A1 COL5A2	Cervical insufficiency
HP:0004872	0.00135542525381	0.25	COL5A1 COL5A2	Incisional hernia
HP:0002035	0.00168976340135	0.375	COL5A1 COL5A2 CCBE1	Rectal prolapse
HP:0100026	0.00168976340135	0.375	COL5A1 COL5A2 CCBE1	Arteriovenous malformation
GO:0098644	0.00195378579303	0.375	COL5A1 COL5A2 COL4A4	complex of collagen trimers
HP:0000993	0.00225842370351	0.25	COL5A1 COL5A2	Molluscoid pseudotumors
HP:0003771	0.00225842370351	0.25	COL5A1 COL5A2	Pulp calcification
HP:0000139	0.00338670821406	0.25	COL5A1 COL5A2	Uterine prolapse
HP:0006243	0.00338670821406	0.25	COL5A1 COL5A2	Phalangeal dislocation
HP:0100823	0.00338670821406	0.25	COL5A1 COL5A2	Genital hernia
HP:0010749	0.00338670821406	0.25	COL5A1 COL5A2	Blepharochalasis
WP:WP2911	0.00364416819939	0.25	COL5A1 COL5A2	miRNA targets in ECM and membrane receptors
HP:0000987	0.0043733297498	0.375	COL17A1 COL5A2 COL5A1	Atypical scarring of skin
HP:0010750	0.00474009355523	0.25	COL5A1 COL5A2	Dermatochalasis
HP:0025019	0.0063183945919	0.25	COL5A1 COL5A2	Arterial rupture
HP:0004947	0.00812142628406	0.25	COL5A1 COL5A2	Arteriovenous fistula
GO:0005581	0.00948397324055	0.375	COL5A1 COL5A2 COL4A4	collagen trimer
GO:0062023	0.00954151915005	0.625	COL5A1 COL17A1 COL26A1 COL5A2 COL4A4	collagen-containing extracellular matrix
HP:0001073	0.0101490036868	0.25	COL5A1 COL5A2	Cigarette-paper scars
HP:0100699	0.0103089116999	0.375	COL17A1 COL5A2 COL5A1	Scarring
HP:0100539	0.0117675405447	0.375	COL5A1 COL5A2 CCBE1	Periorbital edema
GO:0005201	0.0119973146137	0.5	COL5A1 COL17A1 COL5A2 COL4A4	extracellular matrix structural constituent
HP:0004334	0.0121523513052	0.375	COL17A1 COL5A2 COL5A1	Dermal atrophy
REAC:R-HSA-3000170	0.0128161014463	0.25	COL5A1 COL5A2	Syndecan interactions
GO:1903225	0.0131096201623	0.25	COL5A1 COL5A2	negative regulation of endodermal cell differentiation
GO:0005588	0.0131096201623	0.25	COL5A1 COL5A2	collagen type V trimer
HP:0005294	0.014877056319	0.25	COL5A1 COL5A2	Arterial dissection
HP:0012888	0.014877056319	0.25	COL5A1 COL5A2	Abnormal uterine cervix morphology
HP:0001027	0.014877056319	0.25	COL5A1 COL5A2	Soft, doughy skin
REAC:R-HSA-8874081	0.0153043597228	0.25	COL5A1 COL5A2	MET activates PTK2 signaling
HP:0001704	0.0175771621337	0.25	COL5A1 COL5A2	Tricuspid valve prolapse
HP:0000282	0.0194856309351	0.375	COL5A1 COL5A2 CCBE1	Facial edema
HP:0010754	0.020501074829	0.25	COL5A1 COL5A2	Abnormality of the temporomandibular joint
WP:WP3932	0.0231589023106	0.375	COL5A1 COL5A2 COL4A4	Focal adhesion PI3K Akt mTOR signaling pathway
HP:0003834	0.0236486099347	0.25	COL5A1 COL5A2	Shoulder dislocation
HP:0001788	0.0270195830756	0.25	COL5A1 COL5A2	Premature rupture of membranes
HP:0002034	0.0278991450986	0.375	COL5A1 COL5A2 CCBE1	Abnormal rectum morphology
REAC:R-HSA-8875878	0.0310226901604	0.25	COL5A1 COL5A2	MET promotes cell motility

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
COL4A4	LAIR2	0.999		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
COL6A3	LAIR2	0.998		bioplex3_WMM bioplex3_HCT116 WMM_only
PRSS23	COL5A1	0.996	0.178	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
COL17A1	LAIR2	0.996		bioplex3_WMM bioplex3_HCT116 WMM_only
COL5A2	COL5A1	0.991	0.444	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PRSS23	COL5A2	0.988	0.16	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
LAIR2	CCBE1	0.986		bioplex3_HEK293 bioplex3_WMM WMM_only
LAIR2	COL5A2	0.982		bioplex3_HEK293 bioplex3_WMM WMM_only
LAIR2	COL26A1	0.969		bioplex3_HEK293 bioplex3_WMM WMM_only
LAIR2	COL5A1	0.952		bioplex3_HEK293 bioplex3_WMM WMM_only
COL17A1	COL6A3	0.902		bioplex3_WMM WMM_only
COL17A1	COL4A4	0.902		bioplex3_WMM WMM_only
COL4A4	COL6A3	0.902		bioplex3_WMM WMM_only
COL4A4	COL26A1	0.415		bioplex3_WMM WMM_only
CCBE1	COL5A2	0.415		bioplex3_WMM WMM_only
COL4A4	COL5A2	0.415		bioplex3_WMM WMM_only
COL26A1	COL5A2	0.415		bioplex3_WMM WMM_only
COL4A4	CCBE1	0.415		bioplex3_WMM WMM_only
CCBE1	COL26A1	0.415		bioplex3_WMM WMM_only
COL17A1	COL26A1	0.214		bioplex3_WMM WMM_only
COL17A1	CCBE1	0.214		bioplex3_WMM WMM_only
COL6A3	COL26A1	0.214		bioplex3_WMM WMM_only
COL6A3	CCBE1	0.214		bioplex3_WMM WMM_only
COL6A3	COL5A2	0.214	0.312670886076	bioplex3_WMM WMM_only
COL17A1	COL5A2	0.214		bioplex3_WMM WMM_only
COL17A1	COL5A1	0.146		bioplex3_WMM WMM_only
COL6A3	COL5A1	0.146	0.324	bioplex3_WMM WMM_only
CCBE1	COL5A1	0.113		bioplex3_WMM WMM_only
COL4A4	COL5A1	0.106		bioplex3_WMM WMM_only
COL26A1	PRSS23	0.078		bioplex3_WMM WMM_only
COL26A1	COL5A1	0.076		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
COL5A2	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_14646.1
COL17A1	huMAP3_00037.1 huMAP3_00786.1 huMAP3_02779.1 huMAP3_06014.1 huMAP3_08354.1 huMAP3_10095.1 huMAP3_10555.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
COL6A3	huMAP3_00037.1 huMAP3_00786.1 huMAP3_02779.1 huMAP3_06014.1 huMAP3_08354.1 huMAP3_10095.1 huMAP3_10555.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
COL4A4	huMAP3_00037.1 huMAP3_00257.1 huMAP3_02779.1 huMAP3_06014.1 huMAP3_06973.1 huMAP3_07573.1 huMAP3_08354.1 huMAP3_10095.1 huMAP3_10144.1 huMAP3_10555.1 huMAP3_10699.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
LAIR2	huMAP3_00037.1 huMAP3_00786.1 huMAP3_02779.1 huMAP3_06014.1 huMAP3_06973.1 huMAP3_07512.1 huMAP3_08354.1 huMAP3_10095.1 huMAP3_10555.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
CCBE1	huMAP3_00037.1 huMAP3_01515.1 huMAP3_02779.1 huMAP3_06014.1 huMAP3_10031.1 huMAP3_10095.1 huMAP3_11535.1 huMAP3_14499.1
PRSS23	huMAP3_00851.1 huMAP3_01608.1 huMAP3_05229.1 huMAP3_10095.1 huMAP3_11407.1 huMAP3_12644.1 huMAP3_13422.1
COL5A1	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
COL26A1	huMAP3_00037.1 huMAP3_02779.1 huMAP3_07778.1 huMAP3_08065.1 huMAP3_10095.1 huMAP3_11407.1 huMAP3_11856.1 huMAP3_12241.1 huMAP3_12298.1 huMAP3_12304.1 huMAP3_13526.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10095.1