hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10100.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBC | Polyubiquitin-C [Cleaved into: Ubiquitin] | 5 | UniProt NCBI |
| LRRC20 | Leucine-rich repeat-containing protein 20 | 2 | UniProt NCBI |
| ACTC1 | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | 5 | UniProt NCBI |
| ACTBL2 | Beta-actin-like protein 2 (Kappa-actin) | 4 | UniProt NCBI |
| CAP2 | Adenylyl cyclase-associated protein 2 (CAP 2) | 5 | UniProt NCBI |
| ACTA2 | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | 5 | UniProt NCBI |
| PHACTR2 | Phosphatase and actin regulator 2 | 5 | UniProt NCBI |
| CAP1 | Adenylyl cyclase-associated protein 1 (CAP 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428890 | 0.00155943355885 | 0.25 | CAP2 CAP1 | Role of ABL in ROBO-SLIT signaling |
| HPA:0640693 | 0.00687621881252 | 0.25 | ACTA2 CAP2 | endometrium; smooth muscle cells[High] |
| WP:WP383 | 0.0141059358228 | 0.25 | ACTA2 ACTC1 | Striated muscle contraction pathway |
| WP:WP4534 | 0.0184665051061 | 0.25 | ACTA2 ACTC1 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| HPA:0640692 | 0.0208348231702 | 0.25 | ACTA2 CAP2 | endometrium; smooth muscle cells[>=Medium] |
| HP:0005162 | 0.0234438911048 | 0.375 | ACTA2 ACTC1 CAP2 | Abnormal left ventricular function |
| HP:0002875 | 0.0299676437717 | 0.375 | ACTA2 ACTC1 CAP2 | Exertional dyspnea |
| REAC:R-HSA-376176 | 0.0330405864826 | 0.375 | UBC CAP2 CAP1 | Signaling by ROBO receptors |
| HP:0030872 | 0.035181524859 | 0.375 | ACTA2 ACTC1 CAP2 | Abnormal cardiac ventricular function |
| HPA:0641521 | 0.0361861878474 | 0.25 | ACTA2 CAP2 | endometrium; nonciliated luminal epithelial cells[>=Low] |
| HPA:0640691 | 0.0376528572033 | 0.25 | ACTA2 CAP2 | endometrium; smooth muscle cells[>=Low] |
| HPA:0641502 | 0.0391482436309 | 0.25 | ACTA2 CAP2 | endometrium; ciliated epithelial cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAP2 | CAP1 | 1.0 | 0.416 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CAP2 | ACTBL2 | 0.999 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CAP1 | ACTBL2 | 0.998 | 0.340111111111 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| ACTA2 | CAP2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ACTA2 | CAP1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| CAP2 | UBC | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LRRC20 | ACTBL2 | 0.992 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACTC1 | CAP2 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ACTBL2 | PHACTR2 | 0.983 | 0.311333333333 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACTA2 | ACTBL2 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| ACTA2 | PHACTR2 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LRRC20 | ACTA2 | 0.958 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACTC1 | ACTBL2 | 0.93 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| ACTC1 | PHACTR2 | 0.851 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LRRC20 | ACTC1 | 0.735 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAP1 | UBC | 0.591 | bioplex3_WMM WMM_only boldt_WMM | |
| ACTA2 | ACTC1 | 0.449 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM | |
| ACTC1 | CAP1 | 0.342 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAP1 | PHACTR2 | 0.209 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
| CAP2 | PHACTR2 | 0.202 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only |
| UBC | ACTBL2 | 0.102 | bioplex3_WMM WMM_only | |
| ACTA2 | UBC | 0.099 | bioplex3_WMM boldt boldt_WMM WMM_only | |
| ACTC1 | UBC | 0.023 | bioplex3_WMM WMM_only boldt_WMM | |
| LRRC20 | CAP1 | 0.002 | 0.054 | bioplex3_HCT116 WMM_only |
Related Complexes