hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10106.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THAP6 | THAP domain-containing protein 6 | 5 | UniProt NCBI |
| NFE2L3 | Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3) | 5 | UniProt NCBI |
| BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | 5 | UniProt NCBI |
| ASXL1 | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | 5 | UniProt NCBI |
| TET2 | Methylcytosine dioxygenase TET2 (EC 1.14.11.80) | 5 | UniProt NCBI |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | 5 | UniProt NCBI |
| HCFC1 | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | 5 | UniProt NCBI |
| THAP11 | THAP domain-containing protein 11 | 5 | UniProt NCBI |
| HCFC1R1 | Host cell factor C1 regulator 1 (HCF-1 beta-propeller-interacting protein) | 4 | UniProt NCBI |
| OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | 5 | UniProt NCBI |
| C9JHY2 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7354 | 1.68385473419e-08 | 0.3 | HCFC1 ASXL1 OGT | ASXL1-HCFC1-OGT complex |
| CORUM:7221 | 1.41139128787e-06 | 0.3 | HCFC1 KANSL3 OGT | NSL complex |
| KEGG:03083 | 9.02638680743e-06 | 0.4 | BAP1 OGT ASXL1 HCFC1 | Polycomb repressive complex |
| CORUM:7260 | 3.07577115383e-05 | 0.2 | HCFC1 THAP11 | HCFC1-THAP11 subcomplex |
| CORUM:7224 | 3.07577115383e-05 | 0.2 | HCFC1 THAP11 | HCF1-THAP11 complex |
| REAC:R-HSA-5689603 | 6.93299198151e-05 | 0.4 | BAP1 OGT ASXL1 HCFC1 | UCH proteinases |
| CORUM:7259 | 9.22394575203e-05 | 0.2 | HCFC1 THAP11 | HCFC1-THAP11-ZNF143 complex |
| REAC:R-HSA-9772755 | 0.000543255465432 | 0.3 | HCFC1 KANSL3 OGT | Formation of WDR5-containing histone-modifying complexes |
| CORUM:6462 | 0.000859331699025 | 0.2 | HCFC1 OGT | MLL1 complex |
| REAC:R-HSA-212165 | 0.000868813504564 | 0.4 | TET2 OGT KANSL3 HCFC1 | Epigenetic regulation of gene expression |
| CORUM:6460 | 0.00138006084651 | 0.2 | HCFC1 OGT | MLL2 complex |
| CORUM:6469 | 0.00138006084651 | 0.2 | HCFC1 OGT | Set1A complex |
| GO:0044545 | 0.0018977127037 | 0.3 | HCFC1 KANSL3 OGT | NSL complex |
| CORUM:6470 | 0.00202261196918 | 0.2 | HCFC1 OGT | Set1B complex |
| HP:0012138 | 0.00247690070118 | 0.2 | TET2 ASXL1 | Granulocytic hyperplasia |
| HP:0012325 | 0.00247690070118 | 0.2 | TET2 ASXL1 | Chronic myelomonocytic leukemia |
| HP:0031807 | 0.00247690070118 | 0.2 | TET2 ASXL1 | Increased basophil count |
| CORUM:2721 | 0.00367211019763 | 0.2 | HCFC1 OGT | HCF-1 complex |
| REAC:R-HSA-5688426 | 0.00384891807072 | 0.4 | BAP1 OGT ASXL1 HCFC1 | Deubiquitination |
| HP:0031806 | 0.00412666115323 | 0.2 | TET2 ASXL1 | Abnormal basophil count |
| HP:0031408 | 0.00412666115323 | 0.2 | TET2 ASXL1 | Increased proportion of CD25+ mast cells |
| HP:0100845 | 0.0061877325188 | 0.2 | TET2 ASXL1 | Anaphylactic shock |
| HP:0100494 | 0.0061877325188 | 0.2 | TET2 ASXL1 | Abnormal mast cell morphology |
| HP:0031901 | 0.0061877325188 | 0.2 | TET2 ASXL1 | Elevated total serum tryptase |
| WP:WP5087 | 0.0075599887011 | 0.4 | BAP1 OGT ASXL1 HCFC1 | Pleural mesothelioma |
| HP:0032155 | 0.00865966376739 | 0.2 | TET2 ASXL1 | Abdominal cramps |
| HP:0012137 | 0.00865966376739 | 0.2 | TET2 ASXL1 | Abnormal number of granulocyte precursors |
| HP:0001912 | 0.0115420041928 | 0.2 | TET2 ASXL1 | Abnormal basophil morphology |
| HP:0006775 | 0.0115420041928 | 0.2 | TET2 ASXL1 | Multiple myeloma |
| WP:WP5351 | 0.0166734771023 | 0.2 | BAP1 ASXL1 | Kleefstra syndrome |
| REAC:R-HSA-3214847 | 0.0186112177015 | 0.3 | HCFC1 KANSL3 OGT | HATs acetylate histones |
| HP:0012135 | 0.0226469783291 | 0.2 | TET2 ASXL1 | Abnormal granulocytopoietic cell morphology |
| HP:0001279 | 0.025750944258 | 0.3 | BAP1 ASXL1 TET2 | Syncope |
| HP:0005550 | 0.0320940919357 | 0.2 | TET2 ASXL1 | Chronic lymphatic leukemia |
| HP:0005547 | 0.0493214801054 | 0.2 | TET2 ASXL1 | Myeloproliferative disorder |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| THAP11 | OGT | 0.999 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| HCFC1 | THAP11 | 0.998 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| OGT | BAP1 | 0.995 | 0.492 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| HCFC1 | BAP1 | 0.995 | 0.088 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| BAP1 | ASXL1 | 0.995 | 0.15 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 | |
| HCFC1 | OGT | 0.993 | 0.098 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM | |
| HCFC1 | THAP6 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HCFC1 | NFE2L3 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| OGT | THAP6 | 0.985 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KANSL3 | C9JHY2 | 0.977 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| OGT | KANSL3 | 0.976 | 0.170830985915 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| HCFC1 | KANSL3 | 0.973 | 0.102 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| HCFC1 | HCFC1R1 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TET2 | OGT | 0.963 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| OGT | NFE2L3 | 0.961 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| HCFC1R1 | OGT | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| HCFC1 | ASXL1 | 0.955 | 0.084 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| OGT | ASXL1 | 0.39 | 0.224830985915 | bioplex3_WMM WMM_only | |
| KANSL3 | BAP1 | 0.382 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | |
| OGT | C9JHY2 | 0.322 | bioplex3_WMM WMM_only | ||
| HCFC1 | C9JHY2 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | ||
| THAP11 | BAP1 | 0.058 | 0.34 | bioplex_WMM bioplex3_WMM WMM_only | |
| THAP11 | KANSL3 | 0.045 | 0.14 | bioplex3_WMM gupta_WMM WMM_only | |
| KANSL3 | ASXL1 | 0.027 | 0.254 | bioplex3_WMM WMM_only | |
| TET2 | BAP1 | 0.018 | 0.19 | youn_WMM WMM_only | |
| HCFC1 | TET2 | 0.006 | 0.134 | bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM |
Related Complexes