hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10111.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZFP36L2 | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | 5 | UniProt NCBI |
| LPIN1 | Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) | 5 | UniProt NCBI |
| LPIN3 | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | 5 | UniProt NCBI |
| LPIN2 | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1483213 | 2.31434954766e-07 | 0.75 | LPIN1 LPIN2 LPIN3 | Synthesis of PE |
| WP:WP5275 | 2.3750785413e-07 | 0.75 | LPIN1 LPIN2 LPIN3 | Ether lipid biosynthesis |
| WP:WP5101 | 2.84994785564e-07 | 0.75 | LPIN1 LPIN2 LPIN3 | Congenital generalized lipodystrophy |
| REAC:R-HSA-75109 | 3.0856409449e-07 | 0.75 | LPIN1 LPIN2 LPIN3 | Triglyceride biosynthesis |
| REAC:R-HSA-4419969 | 4.0111272408e-07 | 0.75 | LPIN1 LPIN2 LPIN3 | Depolymerization of the Nuclear Lamina |
| REAC:R-HSA-1483191 | 2.4825378684e-06 | 0.75 | LPIN1 LPIN2 LPIN3 | Synthesis of PC |
| REAC:R-HSA-8979227 | 6.94957302308e-06 | 0.75 | LPIN1 LPIN2 LPIN3 | Triglyceride metabolism |
| KEGG:00561 | 8.02117619688e-06 | 0.75 | LPIN1 LPIN2 LPIN3 | Glycerolipid metabolism |
| REAC:R-HSA-2980766 | 2.27017011202e-05 | 0.75 | LPIN1 LPIN2 LPIN3 | Nuclear Envelope Breakdown |
| KEGG:00564 | 2.70408059374e-05 | 0.75 | LPIN1 LPIN2 LPIN3 | Glycerophospholipid metabolism |
| WP:WP236 | 6.90056161201e-05 | 0.75 | LPIN1 LPIN2 LPIN3 | Adipogenesis |
| GO:0008195 | 8.45465618902e-05 | 0.75 | LPIN1 LPIN2 LPIN3 | phosphatidate phosphatase activity |
| KEGG:04936 | 0.000105799991328 | 0.75 | LPIN1 LPIN2 LPIN3 | Alcoholic liver disease |
| KEGG:04150 | 0.000180381602802 | 0.75 | LPIN1 LPIN2 LPIN3 | mTOR signaling pathway |
| GO:0042577 | 0.000215165225046 | 0.75 | LPIN1 LPIN2 LPIN3 | lipid phosphatase activity |
| REAC:R-HSA-1483206 | 0.000261669015753 | 0.75 | LPIN1 LPIN2 LPIN3 | Glycerophospholipid biosynthesis |
| REAC:R-HSA-68875 | 0.00041175394675 | 0.75 | LPIN1 LPIN2 LPIN3 | Mitotic Prophase |
| WP:WP2533 | 0.000894348084449 | 0.5 | LPIN1 LPIN2 | Glycerophospholipid biosynthetic pathway |
| REAC:R-HSA-1483257 | 0.00124221985732 | 0.75 | LPIN1 LPIN2 LPIN3 | Phospholipid metabolism |
| GO:0019432 | 0.00209449363787 | 0.75 | LPIN1 LPIN2 LPIN3 | triglyceride biosynthetic process |
| GO:0046463 | 0.00323764786551 | 0.75 | LPIN1 LPIN2 LPIN3 | acylglycerol biosynthetic process |
| GO:0046460 | 0.00323764786551 | 0.75 | LPIN1 LPIN2 LPIN3 | neutral lipid biosynthetic process |
| REAC:R-HSA-68886 | 0.0131851712206 | 0.75 | LPIN1 LPIN2 LPIN3 | M Phase |
| GO:0032870 | 0.016171683157 | 1.0 | LPIN1 ZFP36L2 LPIN2 LPIN3 | cellular response to hormone stimulus |
| GO:0006641 | 0.0183580179548 | 0.75 | LPIN1 LPIN2 LPIN3 | triglyceride metabolic process |
| GO:0009062 | 0.0291371139957 | 0.75 | LPIN1 LPIN2 LPIN3 | fatty acid catabolic process |
| GO:0009725 | 0.0323627079397 | 1.0 | LPIN1 ZFP36L2 LPIN2 LPIN3 | response to hormone |
| REAC:R-HSA-69278 | 0.0329329593357 | 0.75 | LPIN1 LPIN2 LPIN3 | Cell Cycle, Mitotic |
| GO:0072329 | 0.0405772675542 | 0.75 | LPIN1 LPIN2 LPIN3 | monocarboxylic acid catabolic process |
| GO:0006639 | 0.0449670283878 | 0.75 | LPIN1 LPIN2 LPIN3 | acylglycerol metabolic process |
| GO:0006638 | 0.0449670283878 | 0.75 | LPIN1 LPIN2 LPIN3 | neutral lipid metabolic process |
| CORUM:6090 | 0.049938562206 | 0.25 | LPIN1 | Seipin-lipin1 complex |
| CORUM:7340 | 0.049938562206 | 0.25 | ZFP36L2 | HNRNPD(p45)-ZFP36L2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LPIN2 | LPIN3 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LPIN3 | LPIN1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| LPIN2 | LPIN1 | 0.991 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ZFP36L2 | LPIN1 | 0.95 | 0.104 | hein_WMM bioplex3_WMM WMM_only boldt_WMM |
| LPIN3 | ZFP36L2 | 0.133 | bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes