hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10114.1
Complex Portal: CPX-12350
Confidence: Medium High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
CASC3 | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | 5 | UniProt   NCBI |
CSDE1 | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | 5 | UniProt   NCBI |
GSPT1 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) | 5 | UniProt   NCBI |
MKRN1 | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | 5 | UniProt   NCBI |
NCBP1 | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | 5 | UniProt   NCBI |
ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | 5 | UniProt   NCBI |
PABPC5 | Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5) | 3 | UniProt   NCBI |
IREB2 | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | 5 | UniProt   NCBI |
PABPC4L | Polyadenylate-binding protein 4-like (PABP-4-like) (Poly(A)-binding protein 4-like) | 3 | UniProt   NCBI |
LARP4B | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | 5 | UniProt   NCBI |
PAIP2B | Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B) | 4 | UniProt   NCBI |
PABPC1L | Polyadenylate-binding protein 1-like | 3 | UniProt   NCBI |
APOBEC3F | DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F) | 5 | UniProt   NCBI |
MKRN2 | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | 5 | UniProt   NCBI |
PAIP2 | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) | 5 | UniProt   NCBI |
PAIP1 | Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1) | 5 | UniProt   NCBI |
MKRN3 | Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127) | 5 | UniProt   NCBI |
PUM2 | Pumilio homolog 2 (Pumilio-2) | 5 | UniProt   NCBI |
CHRM4 | Muscarinic acetylcholine receptor M4 | 5 | UniProt   NCBI |
RBMS1 | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) | 5 | UniProt   NCBI |
ZCCHC3 | Zinc finger CCHC domain-containing protein 3 | 5 | UniProt   NCBI |
GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0003723 | 1.89698740126e-10 | 0.85 | PUM2 MKRN3 MKRN2 IREB2 NCBP1 CSDE1 MKRN1 GSPT2 PAIP1 APOBEC3F LARP4B PABPC5 ZCCHC3 CASC3 ETF1 PABPC1L PABPC4L | RNA binding |
  KEGG:03015 | 1.2469459946e-09 | 0.35 | NCBP1 GSPT2 PABPC5 CASC3 ETF1 PABPC1L PABPC4L | mRNA surveillance pathway |
  GO:0003676 | 5.72752264559e-07 | 0.9 | PUM2 MKRN3 PAIP2B MKRN2 IREB2 NCBP1 CSDE1 MKRN1 GSPT2 PAIP1 APOBEC3F LARP4B PABPC5 ZCCHC3 CASC3 ETF1 PABPC1L PABPC4L | nucleic acid binding |
  GO:0097159 | 2.39312722469e-05 | 0.9 | PUM2 MKRN3 PAIP2B MKRN2 IREB2 NCBP1 CSDE1 MKRN1 GSPT2 PAIP1 APOBEC3F LARP4B PABPC5 ZCCHC3 CASC3 ETF1 PABPC1L PABPC4L | organic cyclic compound binding |
  GO:0010608 | 4.53599255591e-05 | 0.45 | PAIP2 PAIP2B IREB2 PUM2 NCBP1 LARP4B CSDE1 ETF1 PAIP1 | post-transcriptional regulation of gene expression |
  GO:0003729 | 7.35209745985e-05 | 0.4 | PUM2 IREB2 NCBP1 PABPC4L ETF1 LARP4B PABPC1L PABPC5 | mRNA binding |
  GO:0006402 | 0.000299123962933 | 0.35 | PUM2 IREB2 NCBP1 CSDE1 LARP4B CASC3 PAIP1 | mRNA catabolic process |
  CORUM:1307 | 0.00038895809385 | 0.1 | CSDE1 PAIP1 | Multiprotein complex (mRNA turnover) |
  GO:1903311 | 0.000926322877529 | 0.35 | PUM2 IREB2 NCBP1 CSDE1 LARP4B CASC3 PAIP1 | regulation of mRNA metabolic process |
  GO:0006401 | 0.00119527836551 | 0.35 | PUM2 IREB2 NCBP1 CSDE1 LARP4B CASC3 PAIP1 | RNA catabolic process |
  GO:0006446 | 0.001717689012 | 0.25 | CSDE1 PAIP2B PAIP1 PAIP2 NCBP1 | regulation of translational initiation |
  GO:0006417 | 0.00198628638798 | 0.35 | PAIP2 PAIP2B NCBP1 LARP4B CSDE1 ETF1 PAIP1 | regulation of translation |
  GO:0061013 | 0.00204848440653 | 0.3 | PUM2 IREB2 CSDE1 LARP4B CASC3 PAIP1 | regulation of mRNA catabolic process |
  GO:0010494 | 0.0025932232649 | 0.25 | LARP4B PABPC1L PABPC5 PUM2 PABPC4L | cytoplasmic stress granule |
  GO:0003730 | 0.00427576105041 | 0.25 | LARP4B PABPC1L PABPC5 PUM2 PABPC4L | mRNA 3'-UTR binding |
  WP:WP107 | 0.00478861325485 | 0.15 | ETF1 PAIP1 GSPT2 | Translation factors |
  REAC:R-HSA-927802 | 0.00479766486005 | 0.2 | ETF1 CASC3 GSPT2 NCBP1 | Nonsense-Mediated Decay (NMD) |
  REAC:R-HSA-975957 | 0.00479766486005 | 0.2 | ETF1 CASC3 GSPT2 NCBP1 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
  GO:0034248 | 0.00615826136069 | 0.35 | PAIP2 PAIP2B NCBP1 LARP4B CSDE1 ETF1 PAIP1 | regulation of amide metabolic process |
  KEGG:03018 | 0.00767821291932 | 0.15 | PABPC1L PABPC5 PABPC4L | RNA degradation |
  GO:0010629 | 0.0105738456627 | 0.45 | PAIP2 IREB2 PUM2 NCBP1 CSDE1 LARP4B CASC3 PAIP2B PAIP1 | negative regulation of gene expression |
  GO:0036464 | 0.0123320734892 | 0.3 | PUM2 APOBEC3F PABPC5 LARP4B PABPC1L PABPC4L | cytoplasmic ribonucleoprotein granule |
  GO:0006413 | 0.0123726406211 | 0.25 | CSDE1 PAIP2B PAIP1 PAIP2 NCBP1 | translational initiation |
  GO:0006412 | 0.013254028285 | 0.4 | PAIP2 PAIP2B NCBP1 GSPT2 LARP4B CSDE1 ETF1 PAIP1 | translation |
  GO:0045182 | 0.015615233108 | 0.25 | ETF1 GSPT2 PAIP1 PAIP2 PAIP2B | translation regulator activity |
  GO:0043043 | 0.0165952799538 | 0.4 | PAIP2 PAIP2B NCBP1 GSPT2 LARP4B CSDE1 ETF1 PAIP1 | peptide biosynthetic process |
  GO:0035770 | 0.019634096865 | 0.3 | PUM2 APOBEC3F PABPC5 LARP4B PABPC1L PABPC4L | ribonucleoprotein granule |
  REAC:R-HSA-9010553 | 0.0209547904469 | 0.2 | ETF1 CASC3 GSPT2 NCBP1 | Regulation of expression of SLITs and ROBOs |
  GO:0048255 | 0.0218974502789 | 0.2 | CSDE1 IREB2 PAIP1 LARP4B | mRNA stabilization |
  GO:0034655 | 0.0266732093789 | 0.35 | PUM2 IREB2 NCBP1 CSDE1 LARP4B CASC3 PAIP1 | nucleobase-containing compound catabolic process |
  GO:1902373 | 0.0415776953599 | 0.2 | CSDE1 IREB2 PAIP1 LARP4B | negative regulation of mRNA catabolic process |
  GO:0043489 | 0.0415776953599 | 0.2 | CSDE1 IREB2 PAIP1 LARP4B | RNA stabilization |
  GO:0046700 | 0.0424869237539 | 0.35 | PUM2 IREB2 NCBP1 CSDE1 LARP4B CASC3 PAIP1 | heterocycle catabolic process |
  GO:0044270 | 0.0431727199773 | 0.35 | PUM2 IREB2 NCBP1 CSDE1 LARP4B CASC3 PAIP1 | cellular nitrogen compound catabolic process |
  GO:0019439 | 0.0467432798236 | 0.35 | PUM2 IREB2 NCBP1 CSDE1 LARP4B CASC3 PAIP1 | aromatic compound catabolic process |
  CORUM:809 | 0.0499436884912 | 0.05 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
---|---|---|---|---|
 PAIP1 |  PAIP2 | 0.999 | 0.08           |          |
 GSPT2 |  GSPT1 | 0.999 | 0.898           |
mutually_exclusive (P62495)        
|
 GSPT2 |  CASC3 | 0.998 | 0.464           |          |
 PAIP1 |  PAIP2B | 0.998 |            |          |
 PAIP2B |  PABPC5 | 0.997 |            |          |
 NCBP1 |  PAIP2B | 0.996 |            |          |
 MKRN3 |  PABPC5 | 0.995 | 0.072           |          |
 NCBP1 |  PAIP1 | 0.995 | 0.114           |          |
 GSPT2 |  MKRN3 | 0.994 | 0.064           |          |
 PUM2 |  PAIP1 | 0.994 |            |          |
 PAIP2B |  CASC3 | 0.994 |            |          |
 MKRN1 |  PAIP2B | 0.992 |            |          |
 PAIP2B |  PAIP2 | 0.992 |            |          |
 GSPT2 |  IREB2 | 0.99 | 0.038           |          |
 IREB2 |  PABPC5 | 0.99 | 0.062           |
structurally_consistent (dimer)        
|
 PAIP1 |  MKRN1 | 0.99 | 0.0713333333333           |          |
 MKRN1 |  GSPT2 | 0.987 | 0.09           |          |
 NCBP1 |  GSPT2 | 0.987 | 0.234           |
structurally_consistent (dimer)        
|
 GSPT2 |  ETF1 | 0.987 | 0.686           |
structurally_consistent (dimer)        
|
 PUM2 |  PAIP2 | 0.986 |            |          |
 PUM2 |  LARP4B | 0.984 |            |          |
 LARP4B |  MKRN3 | 0.984 | 0.052           |          |
 ETF1 |  GSPT1 | 0.983 | 0.648           |
structurally_consistent (dimer)        
|
 MKRN2 |  GSPT2 | 0.983 | 0.168           |          |
 GSPT2 |  ZCCHC3 | 0.982 | 0.076           |          |
 PAIP1 |  MKRN2 | 0.982 | 0.232           |          |
 ZCCHC3 |  PAIP2B | 0.982 |            |          |
 LARP4B |  CASC3 | 0.98 | 0.277142857143           |          |
 PAIP1 |  MKRN3 | 0.978 | 0.07           |          |
 PUM2 |  GSPT2 | 0.974 |            |          |
 PAIP1 |  LARP4B | 0.974 | 0.086           |
mutually_exclusive (P0CB38)        
|
 MKRN2 |  PAIP2 | 0.973 | 0.128           |          |
 PUM2 |  PABPC5 | 0.966 |            |          |
 MKRN1 |  LARP4B | 0.966 | 0.084           |          |
 CSDE1 |  LARP4B | 0.966 | 0.408           |          |
 APOBEC3F |  LARP4B | 0.961 | 0.084           |          |
 PAIP1 |  GSPT2 | 0.961 | 0.246           |
mutually_exclusive (P0CB38)        
|
 PUM2 |  PAIP2B | 0.96 |            |          |
 PAIP1 |  APOBEC3F | 0.959 | 0.1           |          |
 PAIP1 |  ZCCHC3 | 0.958 | 0.062           |          |
 RBMS1 |  ZCCHC3 | 0.957 | 0.074           |          |
 LARP4B |  ZCCHC3 | 0.956 | 0.054           |          |
 CASC3 |  PABPC5 | 0.956 | 0.462           |          |
 GSPT1 |  CHRM4 | 0.955 |            |          |
 PAIP2 |  PABPC5 | 0.952 | 0.23           |          |
 MKRN2 |  ZCCHC3 | 0.951 | 0.052           |          |
 APOBEC3F |  GSPT2 | 0.951 | 0.058           |          |
 NCBP1 |  MKRN1 | 0.951 | 0.13           |          |
 PAIP2 |  CASC3 | 0.948 | 0.116           |          |
 MKRN2 |  MKRN1 | 0.944 | 0.106           |          |
 PAIP1 |  CASC3 | 0.931 | 0.317076923077           |          |
 ZCCHC3 |  PAIP2 | 0.929 | 0.032           |          |
 MKRN2 |  PAIP2B | 0.92 |            |          |
 MKRN1 |  ZCCHC3 | 0.919 | 0.048           |          |
 APOBEC3F |  ZCCHC3 | 0.919 | 0.064           |          |
 GSPT2 |  PAIP2 | 0.915 | 0.17           |          |
 PAIP1 |  IREB2 | 0.914 | 0.1124           |          |
 ZCCHC3 |  PABPC5 | 0.911 | 0.062           |          |
 MKRN1 |  CASC3 | 0.907 | 0.126           |          |
 APOBEC3F |  PABPC5 | 0.907 | 0.07           |          |
 NCBP1 |  PABPC5 | 0.884 | 0.178           |          |
 LARP4B |  PAIP2 | 0.882 | 0.112           |          |
 APOBEC3F |  MKRN1 | 0.882 | 0.108           |          |
 MKRN2 |  CASC3 | 0.881 | 0.158           |          |
 RBMS1 |  LARP4B | 0.881 | 0.172           |          |
 PUM2 |  NCBP1 | 0.879 |            |          |
 APOBEC3F |  CASC3 | 0.861 | 0.09           |          |
 APOBEC3F |  IREB2 | 0.861 | 0.052           |          |
 PUM2 |  ZCCHC3 | 0.856 |            |          |
 MKRN2 |  IREB2 | 0.854 | 0.06           |          |
 NCBP1 |  CASC3 | 0.853 | 0.594           |          |
 NCBP1 |  MKRN2 | 0.848 | 0.124           |          |
 PUM2 |  IREB2 | 0.845 |            |          |
 MKRN1 |  PAIP2 | 0.831 | 0.128           |          |
 PUM2 |  MKRN3 | 0.827 |            |          |
 APOBEC3F |  MKRN2 | 0.825 | 0.0941           |          |
 NCBP1 |  PAIP2 | 0.824 | 0.074           |          |
 APOBEC3F |  MKRN3 | 0.78 | 0.106           |          |
 LARP4B |  PAIP2B | 0.775 |            |          |
 PAIP2B |  MKRN3 | 0.748 |            |          |
 CASC3 |  MKRN3 | 0.745 | 0.114           |          |
 PAIP1 |  PABPC5 | 0.744 | 0.262           |          |
 APOBEC3F |  PAIP2B | 0.743 |            |          |
 NCBP1 |  MKRN3 | 0.736 | 0.082           |          |
 MKRN1 |  MKRN3 | 0.736 | 0.1           |          |
 IREB2 |  PAIP2 | 0.73 | 0.05           |          |
 PUM2 |  MKRN1 | 0.718 |            |          |
 MKRN2 |  PABPC5 | 0.717 | 0.13           |          |
 GSPT1 |  CASC3 | 0.715 | 0.562           |          |
 PUM2 |  APOBEC3F | 0.701 |            |          |
 PAIP2 |  MKRN3 | 0.689 | 0.106           |          |
 PUM2 |  RBMS1 | 0.663 |            |          |
 MKRN1 |  PABPC5 | 0.631 | 0.096           |          |
 APOBEC3F |  PAIP2 | 0.62 | 0.142           |          |
 IREB2 |  CASC3 | 0.585 | 0.048           |          |
 ZCCHC3 |  MKRN3 | 0.563 | 0.072           |          |
 MKRN2 |  MKRN3 | 0.561 | 0.134           |          |
 NCBP1 |  IREB2 | 0.558 | 0.068           |          |
 NCBP1 |  ZCCHC3 | 0.558 | 0.1           |          |
 MKRN2 |  GSPT1 | 0.524 | 0.178           |          |
 RBMS1 |  CASC3 | 0.499 | 0.13           |          |
 MKRN1 |  RBMS1 | 0.484 | 0.124           |          |
 PUM2 |  MKRN2 | 0.45 |            |          |
 IREB2 |  PAIP2B | 0.447 |            |          |
 GSPT1 |  ZCCHC3 | 0.412 | 0.03           |          |
 NCBP1 |  APOBEC3F | 0.409 | 0.122           |          |
 MKRN1 |  IREB2 | 0.389 | 0.08           |          |
 GSPT1 |  MKRN3 | 0.388 | 0.082           |          |
 IREB2 |  GSPT1 | 0.356 | 0.064           |          |
 IREB2 |  ZCCHC3 | 0.351 | 0.054           |          |
 IREB2 |  MKRN3 | 0.346 | 0.1           |          |
 MKRN2 |  LARP4B | 0.304 | 0.154           |          |
 PUM2 |  CASC3 | 0.296 |            |          |
 MKRN1 |  GSPT1 | 0.262 | 0.132           |          |
 ZCCHC3 |  CASC3 | 0.251 | 0.074           |          |
 MKRN2 |  RBMS1 | 0.248 | 0.114           |          |
 GSPT1 |  PAIP2 | 0.243 | 0.106           |          |
 PAIP1 |  GSPT1 | 0.228 | 0.182           |          |
 APOBEC3F |  RBMS1 | 0.22 | 0.07           |          |
 APOBEC3F |  GSPT1 | 0.203 | 0.102           |          |
 IREB2 |  LARP4B | 0.2 | 0.048           |          |
 NCBP1 |  LARP4B | 0.195 | 0.21           |          |
 NCBP1 |  GSPT1 | 0.194 | 0.488           |          |
 RBMS1 |  PAIP2 | 0.193 | 0.106           |          |
 CSDE1 |  PABPC5 | 0.164 | 0.25           |          |
 LARP4B |  PABPC5 | 0.142 | 0.186           |          |
 RBMS1 |  PAIP2B | 0.138 |            |          |
 MKRN1 |  CSDE1 | 0.135 | 0.078           |          |
 CSDE1 |  ZCCHC3 | 0.119 | 0.094           |          |
 PAIP1 |  RBMS1 | 0.119 | 0.12           |          |
 LARP4B |  GSPT1 | 0.113 | 0.284           |          |
 RBMS1 |  MKRN3 | 0.112 | 0.1           |          |
 PUM2 |  GSPT1 | 0.106 |            |          |
 NCBP1 |  RBMS1 | 0.085 | 0.128           |          |
 CSDE1 |  PAIP2B | 0.073 |            |          |
 CSDE1 |  MKRN3 | 0.066 | 0.046           |          |
 ETF1 |  PABPC5 | 0.044 | 0.274           |          |
 IREB2 |  CSDE1 | 0.034 | 0.048           |          |
 IREB2 |  RBMS1 | 0.026 | 0.05           |          |
 MKRN2 |  ETF1 | 0.025 | 0.13           |          |
 APOBEC3F |  CSDE1 | 0.023 | 0.072           |          |
 RBMS1 |  CSDE1 | 0.02 | 0.0573333333333           |          |
 NCBP1 |  CHRM4 | 0.017 |            |          |
 CSDE1 |  PAIP2 | 0.015 | 0.368           |          |
 GSPT1 |  PAIP2B | 0.014 |            |          |
 PAIP1 |  CSDE1 | 0.014 | 0.17           |          |
 GSPT2 |  CSDE1 | 0.013 | 0.334           |          |
 PUM2 |  CSDE1 | 0.011 |            |          |
 GSPT2 |  LARP4B | 0.01 | 0.21           |
mutually_exclusive (P0CB38)        
|
 ETF1 |  PAIP2B | 0.01 |            |          |
 MKRN1 |  ETF1 | 0.009 | 0.136           |          |
 CSDE1 |  CASC3 | 0.008 | 0.21           |          |
 GSPT1 |  PABPC5 | 0.008 | 0.26           |          |
 ETF1 |  PAIP2 | 0.007 | 0.178           |          |
 ETF1 |  CSDE1 | 0.007 | 0.492           |          |
 GSPT2 |  RBMS1 | 0.006 | 0.238333333333           |          |
 RBMS1 |  GSPT1 | 0.006 | 0.11           |          |
 IREB2 |  ETF1 | 0.006 | 0.086           |          |
 ETF1 |  MKRN3 | 0.006 | 0.038           |          |
 APOBEC3F |  ETF1 | 0.004 | 0.098           |          |
 MKRN2 |  CSDE1 | 0.004 | 0.184           |          |
 ETF1 |  LARP4B | 0.004 | 0.234           |          |
 PAIP1 |  ETF1 | 0.003 | 0.252           |          |
 ETF1 |  ZCCHC3 | 0.003 | 0.062           |          |
 ETF1 |  CASC3 | 0.003 | 0.682           |          |
 ETF1 |  RBMS1 | 0.003 | 0.162           |          |
 CSDE1 |  GSPT1 | 0.002 | 0.312           |          |
 NCBP1 |  CSDE1 | 0.002 | 0.436           |          |
 PUM2 |  ETF1 | 0.002 |            |          |
 NCBP1 |  ETF1 | 0.001 | 0.44           |          |
Related Complexes