hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10123.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNKS | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | 5 | UniProt NCBI |
| GMDS | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | 5 | UniProt NCBI |
| CGREF1 | Cell growth regulator with EF hand domain protein 1 (Cell growth regulatory gene 11 protein) (Hydrophobestin) | 5 | UniProt NCBI |
| TNKS2 | Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5545619 | 1.02525705128e-05 | 0.5 | TNKS TNKS2 | XAV939 stabilizes AXIN |
| CORUM:1219 | 1.53774525569e-05 | 0.5 | TNKS TNKS2 | Tankyrin 1-tankyrin 2-TRF1 complex |
| WP:WP3645 | 0.000390164573598 | 0.5 | TNKS TNKS2 | NAD biosynthetic pathways |
| REAC:R-HSA-4791275 | 0.00539805716719 | 0.5 | TNKS TNKS2 | Signaling by WNT in cancer |
| REAC:R-HSA-4641257 | 0.0146019089592 | 0.5 | TNKS TNKS2 | Degradation of AXIN |
| GO:0070212 | 0.0168521501606 | 0.5 | TNKS TNKS2 | protein poly-ADP-ribosylation |
| REAC:R-HSA-8948751 | 0.0232149434748 | 0.5 | TNKS TNKS2 | Regulation of PTEN stability and activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TNKS | TNKS2 | 0.999 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| GMDS | TNKS2 | 0.998 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| GMDS | TNKS | 0.998 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| TNKS2 | CGREF1 | 0.988 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TNKS | CGREF1 | 0.988 | 0.066 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes