hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10125.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLR6 | Toll-like receptor 6 (CD antigen CD286) | 5 | UniProt NCBI |
| ALDH16A1 | Aldehyde dehydrogenase family 16 member A1 | 4 | UniProt NCBI |
| DERA | Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) | 5 | UniProt NCBI |
| TLR1 | Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) | 5 | UniProt NCBI |
| PCMT1 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3877 | 0.000616503269292 | 0.4 | TLR1 TLR6 | MYD88 distinct input output pathway |
| REAC:R-HSA-5603041 | 0.0013810496636 | 0.4 | TLR1 TLR6 | IRAK4 deficiency (TLR2/4) |
| REAC:R-HSA-5602498 | 0.0013810496636 | 0.4 | TLR1 TLR6 | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5686938 | 0.001593300657 | 0.4 | TLR1 TLR6 | Regulation of TLR by endogenous ligand |
| WP:WP3858 | 0.00205749802636 | 0.4 | TLR1 TLR6 | Toll like receptor signaling related to MyD88 |
| REAC:R-HSA-5602358 | 0.00531742996423 | 0.4 | TLR1 TLR6 | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.00531742996423 | 0.4 | TLR1 TLR6 | Diseases of Immune System |
| GO:0070340 | 0.0140440992017 | 0.4 | TLR1 TLR6 | detection of bacterial lipopeptide |
| KEGG:04620 | 0.0168082536599 | 0.4 | TLR1 TLR6 | Toll-like receptor signaling pathway |
| WP:WP75 | 0.0197951791935 | 0.4 | TLR1 TLR6 | Toll like receptor signaling pathway |
| GO:0035663 | 0.0280843539964 | 0.4 | TLR1 TLR6 | Toll-like receptor 2 binding |
| GO:0042494 | 0.0280843539964 | 0.4 | TLR1 TLR6 | detection of bacterial lipoprotein |
| KEGG:05152 | 0.0471742362289 | 0.4 | TLR1 TLR6 | Tuberculosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DERA | ALDH16A1 | 1.0 | 0.786 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction |
| TLR6 | TLR1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DERA | TLR1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ALDH16A1 | TLR1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ALDH16A1 | PCMT1 | 0.977 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DERA | PCMT1 | 0.964 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| DERA | TLR6 | 0.193 | bioplex_WMM bioplex3_WMM WMM_only | |
| ALDH16A1 | TLR6 | 0.189 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCMT1 | TLR1 | 0.011 | bioplex3_HEK293 bioplex () | |
| PCMT1 | TLR6 | 0.002 | bioplex3_HEK293 bioplex () |
Related Complexes