hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10130.1
Complex Portal: CPX-20794
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MSH2 | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | 5 | UniProt NCBI |
| GMFG | Glia maturation factor gamma (GMF-gamma) | 4 | UniProt NCBI |
| VAT1 | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | 5 | UniProt NCBI |
| GMFB | Glia maturation factor beta (GMF-beta) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0071846 | 0.0028092043205 | 0.5 | GMFG GMFB | actin filament debranching |
| CORUM:375 | 0.0249718442456 | 0.25 | MSH2 | MSH2-MSH3 complex |
| CORUM:378 | 0.0249718442456 | 0.25 | MSH2 | MSH2-MSH3 complex |
| GO:0034316 | 0.042122686785 | 0.5 | GMFG GMFB | negative regulation of Arp2/3 complex-mediated actin nucleation |
| CORUM:286 | 0.049938562206 | 0.25 | MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:289 | 0.049938562206 | 0.25 | MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:374 | 0.049938562206 | 0.25 | MSH2 | MSH2-MSH6 complex |
| CORUM:377 | 0.049938562206 | 0.25 | MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:1078 | 0.049938562206 | 0.25 | MSH2 | MSH2-MSH6 complex |
| CORUM:2740 | 0.049938562206 | 0.25 | MSH2 | MSH2-MSH6 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GMFG | GMFB | 0.994 | 0.094 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GMFG | MSH2 | 0.986 | 0.028 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VAT1 | GMFG | 0.975 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VAT1 | GMFB | 0.147 | 0.092 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GMFB | MSH2 | 0.091 | 0.016 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| VAT1 | MSH2 | 0.018 | 0.072 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
Related Complexes