hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10131.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIX2 | Homeobox protein SIX2 (Sine oculis homeobox homolog 2) | 5 | UniProt NCBI |
| EYA1 | Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) | 5 | UniProt NCBI |
| CCDC85A | Coiled-coil domain-containing protein 85A | 3 | UniProt NCBI |
| EYA2 | Eyes absent homolog 2 (EC 3.1.3.48) | 5 | UniProt NCBI |
| SIX1 | Homeobox protein SIX1 (Sine oculis homeobox homolog 1) | 5 | UniProt NCBI |
| ERCC6L | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | 5 | UniProt NCBI |
| EYA3 | Eyes absent homolog 3 (EC 3.1.3.48) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140789 | 3.36420143768e-06 | 0.428571428571 | EYA2 EYA1 EYA3 | histone phosphatase activity |
| GO:0140793 | 3.36420143768e-06 | 0.428571428571 | EYA2 EYA1 EYA3 | histone H2AXY142 phosphatase activity |
| CORUM:7364 | 2.05265451394e-05 | 0.285714285714 | SIX2 EYA1 | EYA1-SIX2 complex |
| CORUM:7363 | 2.05265451394e-05 | 0.285714285714 | SIX1 EYA1 | EYA1-SIX1 complex |
| WP:WP5053 | 9.79338267472e-05 | 0.428571428571 | SIX2 EYA1 SIX1 | Development of ureteric collection system |
| WP:WP5236 | 9.79338267472e-05 | 0.428571428571 | SIX2 EYA1 SIX1 | Markers of kidney cell lineage |
| REAC:R-HSA-5693565 | 0.000734927167534 | 0.428571428571 | EYA2 EYA1 EYA3 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.000766722633593 | 0.428571428571 | EYA2 EYA1 EYA3 | DNA Double Strand Break Response |
| HP:0011388 | 0.000999430167489 | 0.285714285714 | SIX1 EYA1 | Enlarged cochlear aqueduct |
| HP:0009798 | 0.000999430167489 | 0.285714285714 | SIX1 EYA1 | Euthyroid goiter |
| HP:0004458 | 0.000999430167489 | 0.285714285714 | SIX1 EYA1 | Dilatated internal auditory canal |
| HP:0100274 | 0.00166533696614 | 0.285714285714 | SIX1 EYA1 | Gustatory lacrimation |
| HP:0009796 | 0.00249743559672 | 0.285714285714 | SIX1 EYA1 | Branchial cyst |
| HP:0000376 | 0.00349561220575 | 0.285714285714 | SIX1 EYA1 | Incomplete partition of the cochlea type II |
| HP:0008586 | 0.00349561220575 | 0.285714285714 | SIX1 EYA1 | Hypoplasia of the cochlea |
| HP:0011387 | 0.00349561220575 | 0.285714285714 | SIX1 EYA1 | Enlarged vestibular aqueduct |
| GO:1901099 | 0.00382182132582 | 0.428571428571 | EYA2 EYA1 EYA3 | negative regulation of signal transduction in absence of ligand |
| GO:2001240 | 0.00382182132582 | 0.428571428571 | EYA2 EYA1 EYA3 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| HP:0004712 | 0.0046597529865 | 0.285714285714 | SIX1 EYA1 | Renal malrotation |
| HP:0011373 | 0.0046597529865 | 0.285714285714 | SIX1 EYA1 | Incomplete partition of the cochlea |
| HP:0100799 | 0.0046597529865 | 0.285714285714 | SIX1 EYA1 | Neoplasm of the middle ear |
| HP:0009797 | 0.0046597529865 | 0.285714285714 | SIX1 EYA1 | Cholesteatoma |
| HP:0011395 | 0.0046597529865 | 0.285714285714 | SIX1 EYA1 | Aplasia/Hypoplasia of the cochlea |
| HP:0008554 | 0.00598974417902 | 0.285714285714 | SIX1 EYA1 | Cochlear malformation |
| HP:0008774 | 0.00598974417902 | 0.285714285714 | SIX1 EYA1 | Aplasia/Hypoplasia of the inner ear |
| HP:0009795 | 0.00748547207011 | 0.285714285714 | SIX1 EYA1 | Branchial fistula |
| HP:0011094 | 0.00748547207011 | 0.285714285714 | SIX1 EYA1 | Increased overbite |
| HP:0000799 | 0.00748547207011 | 0.285714285714 | SIX1 EYA1 | Renal steatosis |
| HP:0007925 | 0.00748547207011 | 0.285714285714 | SIX1 EYA1 | Lacrimal duct aplasia |
| GO:2001239 | 0.0077027737875 | 0.428571428571 | EYA2 EYA1 EYA3 | regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| REAC:R-HSA-5693532 | 0.00814566466165 | 0.428571428571 | EYA2 EYA1 EYA3 | DNA Double-Strand Break Repair |
| HP:0100267 | 0.00914682299331 | 0.285714285714 | SIX1 EYA1 | Lip pit |
| WP:WP4823 | 0.00991981492579 | 0.285714285714 | SIX1 EYA1 | Genes controlling nephrogenesis |
| HP:0007678 | 0.0151234779917 | 0.285714285714 | SIX1 EYA1 | Lacrimal duct stenosis |
| HP:0004452 | 0.0254041861805 | 0.285714285714 | SIX1 EYA1 | Abnormality of the middle ear ossicles |
| HP:0009794 | 0.0254041861805 | 0.285714285714 | SIX1 EYA1 | Branchial anomaly |
| GO:0038034 | 0.0281770340738 | 0.428571428571 | EYA2 EYA1 EYA3 | signal transduction in absence of ligand |
| GO:0097192 | 0.0281770340738 | 0.428571428571 | EYA2 EYA1 EYA3 | extrinsic apoptotic signaling pathway in absence of ligand |
| HP:0011384 | 0.0283864349721 | 0.285714285714 | SIX1 EYA1 | Abnormality of the internal auditory canal |
| HP:0000074 | 0.0283864349721 | 0.285714285714 | SIX1 EYA1 | Ureteropelvic junction obstruction |
| HP:0012780 | 0.0283864349721 | 0.285714285714 | SIX1 EYA1 | Neoplasm of the ear |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SIX2 | ERCC6L | 0.999 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EYA2 | SIX2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA1 | SIX1 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SIX1 | ERCC6L | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA1 | SIX2 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CCDC85A | SIX1 | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EYA3 | SIX2 | 0.973 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EYA1 | EYA2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| EYA3 | EYA2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| EYA3 | EYA1 | 0.265 | bioplex_WMM bioplex3_WMM WMM_only | |
| EYA1 | ERCC6L | 0.216 | bioplex_WMM bioplex3_WMM WMM_only | |
| SIX2 | SIX1 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | |
| EYA3 | ERCC6L | 0.161 | 0.102 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EYA2 | ERCC6L | 0.143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes