List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_10133.1

Confidence: Medium High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
ETV5	ETS translocation variant 5 (Ets-related protein ERM)	5	UniProt   NCBI
ATF2	Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)	5	UniProt   NCBI
DET1	DET1 homolog (De-etiolated-1 homolog)	5	UniProt   NCBI
ETV1	ETS translocation variant 1 (Ets-related protein 81)	5	UniProt   NCBI
FOS	Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)	5	UniProt   NCBI
FOSL2	Fos-related antigen 2 (FRA-2)	5	UniProt   NCBI
TRIB1	Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)	5	UniProt   NCBI
FOSL1	Fos-related antigen 1 (FRA-1)	5	UniProt   NCBI
CREB5	Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)	5	UniProt   NCBI
TRIB2	Tribbles homolog 2 (TRB-2)	5	UniProt   NCBI
JUND	Transcription factor JunD (Transcription factor AP-1 subunit JunD)	5	UniProt   NCBI
DNPH1	5-hydroxymethyl-dUMP N-hydrolase (EC 3.2.2.-) (2'-deoxynucleoside 5'-phosphate N-hydrolase 1) (c-Myc-responsive protein RCL)	5	UniProt   NCBI
COP1	E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)	5	UniProt   NCBI
ATF3	Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)	5	UniProt   NCBI
STK40	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495)	5	UniProt   NCBI
JUN	Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)	5	UniProt   NCBI
FOSB	Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB)	5	UniProt   NCBI
JUNB	Transcription factor JunB (Transcription factor AP-1 subunit JunB)	5	UniProt   NCBI
UBE2E1	Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1)	5	UniProt   NCBI
ATF7	Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)	5	UniProt   NCBI
ROBO3	Roundabout homolog 3 (Roundabout-like protein 3)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP5373	1.14182988505e-05	0.235294117647	FOS FOSB JUND JUN	Role of hypoxia angiogenesis and FGF pathway in OA chondrocyte hypertrophy
REAC:R-HSA-9031628	1.42418816602e-05	0.235294117647	FOS FOSB TRIB1 JUND	NGF-stimulated transcription
WP:WP366	2.1387870509e-05	0.294117647059	FOS FOSB JUND JUN ATF3	TGF beta signaling pathway
KEGG:05031	2.87338346254e-05	0.235294117647	FOS FOSB JUN CREB5	Amphetamine addiction
CORUM:2694	5.44233315652e-05	0.117647058824	FOS JUN	ERG-JUN-FOS DNA-protein complex
CORUM:2695	5.44233315652e-05	0.117647058824	FOS JUN	ETS2-FOS-JUN complex
CORUM:2693	5.44233315652e-05	0.117647058824	FOS JUN	NFAT-JUN-FOS DNA-protein complex
CORUM:6092	5.44233315652e-05	0.117647058824	ATF3 JUN	c-Jun-ATF3 complex
KEGG:04657	9.70457024887e-05	0.235294117647	FOS FOSB JUND JUN	IL-17 signaling pathway
REAC:R-HSA-198725	0.000123301748979	0.235294117647	FOS FOSB TRIB1 JUND	Nuclear Events (kinase and transcription factor activation)
CORUM:6235	0.000163158265417	0.117647058824	FOS JUN	c-Fos-c-Jun-SAF-1 complex
GO:0035976	0.000261258639543	0.176470588235	FOS JUND JUN	transcription factor AP-1 complex
CORUM:2692	0.000326093232852	0.117647058824	FOS JUN	SMAD3-SMAD4-cJun-cFos complex
CORUM:2754	0.000326093232852	0.117647058824	JUND FOSB	JUND-FOSB-SMAD3-SMAD4 complex
KEGG:04380	0.000482500812029	0.235294117647	FOS FOSB JUND JUN	Osteoclast differentiation
CORUM:1214	0.000543116825549	0.117647058824	DET1 COP1	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
GO:0051173	0.000551480711379	0.764705882353	DET1 ATF7 TRIB1 COP1 FOS JUND JUN ETV5 ATF3 TRIB2 CREB5 ETV1 UBE2E1	positive regulation of nitrogen compound metabolic process
KEGG:05030	0.000817825846008	0.176470588235	CREB5 JUN FOSB	Cocaine addiction
REAC:R-HSA-187037	0.0013100796278	0.235294117647	FOS FOSB TRIB1 JUND	Signaling by NTRK1 (TRKA)
WP:WP437	0.00221262920629	0.235294117647	FOS FOSB JUND JUN	EGF EGFR signaling pathway
REAC:R-HSA-166520	0.00249262057335	0.235294117647	FOS FOSB TRIB1 JUND	Signaling by NTRKs
GO:0010604	0.00256154854609	0.764705882353	DET1 ATF7 TRIB1 COP1 FOS JUND JUN ETV5 ATF3 TRIB2 CREB5 ETV1 UBE2E1	positive regulation of macromolecule metabolic process
GO:0035497	0.00364711882004	0.176470588235	CREB5 JUN ATF7	cAMP response element binding
REAC:R-HSA-9018519	0.00382476869337	0.235294117647	FOS FOSB JUND JUN	Estrogen-dependent gene expression
WP:WP2840	0.00620573382754	0.176470588235	FOS JUN FOSB	Hair follicle development cytodifferentiation part 3 of 3
KEGG:04928	0.00683931251218	0.176470588235	FOS JUND CREB5	Parathyroid hormone synthesis, secretion and action
GO:0000981	0.00738489542992	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0009893	0.00767879216834	0.764705882353	DET1 ATF7 TRIB1 COP1 FOS JUND JUN ETV5 ATF3 TRIB2 CREB5 ETV1 UBE2E1	positive regulation of metabolic process
KEGG:04915	0.00928744032248	0.176470588235	FOS JUN CREB5	Estrogen signaling pathway
GO:0000977	0.00940686288873	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	RNA polymerase II transcription regulatory region sequence-specific DNA binding
WP:WP4919	0.00948614401728	0.117647058824	FOS JUN	Neuroinflammation
WP:WP2355	0.00952471276525	0.176470588235	FOS JUND FOSB	Corticotropin releasing hormone signaling pathway
KEGG:04668	0.0102146061067	0.176470588235	FOS JUN CREB5	TNF signaling pathway
GO:0003700	0.0125758974792	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	DNA-binding transcription factor activity
WP:WP2435	0.0130614919572	0.117647058824	FOS JUN	Quercetin and Nf kB AP 1 induced apoptosis
WP:WP4928	0.0130614919572	0.117647058824	FOS JUN	MAPK pathway in congenital thyroid cancer
KEGG:04926	0.0149258720629	0.176470588235	FOS JUN CREB5	Relaxin signaling pathway
REAC:R-HSA-8939211	0.0167726821467	0.235294117647	FOS FOSB JUND JUN	ESR-mediated signaling
GO:0000785	0.0183407545918	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	chromatin
REAC:R-HSA-450341	0.0183854258919	0.117647058824	FOS JUN	Activation of the AP-1 family of transcription factors
GO:0000976	0.0194982068955	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	transcription cis-regulatory region binding
GO:0001067	0.0196686651866	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	transcription regulatory region nucleic acid binding
WP:WP516	0.0219005077051	0.117647058824	ATF3 JUND	Hypertrophy model
WP:WP712	0.0271595202031	0.117647058824	FOS JUN	Estrogen signaling pathway
KEGG:04120	0.0287528879768	0.176470588235	DET1 UBE2E1 COP1	Ubiquitin mediated proteolysis
GO:1990837	0.0290633756618	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	sequence-specific double-stranded DNA binding
WP:WP1528	0.0299978875622	0.117647058824	FOS JUN	Physiological and pathological hypertrophy of the heart
GO:0032993	0.0302890479741	0.529411764706	ATF7 FOSB ATF3 FOS JUND JUN ETV5 CREB5 ETV1	protein-DNA complex
WP:WP3612	0.0329751100931	0.117647058824	FOS JUN	Photodynamic therapy induced NFE2L2 NRF2 survival signaling
GO:0045893	0.0356552018214	0.529411764706	UBE2E1 ATF7 ATF3 FOS JUND JUN ETV5 CREB5 ETV1	positive regulation of DNA-templated transcription
GO:1902680	0.0365278115616	0.529411764706	UBE2E1 ATF7 ATF3 FOS JUND JUN ETV5 CREB5 ETV1	positive regulation of RNA biosynthetic process
KEGG:05161	0.0376063730767	0.176470588235	FOS JUN CREB5	Hepatitis B
GO:0045944	0.0416213650714	0.470588235294	UBE2E1 ATF7 ATF3 FOS JUND JUN ETV5 ETV1	positive regulation of transcription by RNA polymerase II
WP:WP3613	0.0427370242569	0.117647058824	ATF3 UBE2E1	Photodynamic therapy induced unfolded protein response
GO:0000978	0.0428849466874	0.470588235294	FOSB ATF7 CREB5 JUND JUN ATF3 FOS ETV1	RNA polymerase II cis-regulatory region sequence-specific DNA binding
KEGG:04024	0.0454868973289	0.176470588235	FOS JUN CREB5	cAMP signaling pathway
WP:WP3972	0.0462667850985	0.117647058824	FOS JUN	PDGFR beta pathway
WP:WP289	0.0496074822832	0.176470588235	FOS JUN ATF3	Myometrial relaxation and contraction pathways
KEGG:05207	0.0497933258595	0.176470588235	FOS JUN CREB5	Chemical carcinogenesis - receptor activation



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
COP1	TRIB1	1.0
JUNB	ATF7	1.0	0.136
FOS	JUND	1.0
DET1	TRIB1	1.0
ATF2	JUNB	1.0	0.094
JUNB	JUN	1.0	0.326120260424
STK40	DET1	0.999
FOS	JUNB	0.999
CREB5	JUN	0.999
DET1	COP1	0.999
ATF7	JUN	0.999	0.444
JUNB	FOSL2	0.999	0.106
COP1	JUNB	0.999	0.068
UBE2E1	DET1	0.999
FOSB	JUNB	0.999
COP1	JUN	0.999	0.238
ATF7	FOSL2	0.999	0.112
ETV5	COP1	0.999
JUN	FOSL2	0.999	0.32
ATF2	JUN	0.999	0.376827743417
CREB5	JUNB	0.999
JUND	JUN	0.998	0.45
ETV1	COP1	0.998
JUND	ATF7	0.998	0.126
JUND	FOSL2	0.998	0.174
STK40	TRIB1	0.998
JUNB	JUND	0.998	0.076
FOS	JUN	0.998
ATF2	JUND	0.998	0.104
TRIB2	TRIB1	0.998
DET1	TRIB2	0.998
FOS	ATF2	0.998
FOSL1	JUNB	0.998	0.156
CREB5	JUND	0.998
TRIB2	COP1	0.998
ATF2	ATF7	0.997	0.244
COP1	JUND	0.997	0.088
STK40	TRIB2	0.997
STK40	ETV5	0.996
FOSL1	ATF2	0.996	0.094
ATF3	JUN	0.996	0.261319148936
ETV5	DET1	0.995
COP1	FOSL1	0.995	0.132
FOSL1	JUND	0.995	0.152
CREB5	ATF7	0.995
ATF2	CREB5	0.995
UBE2E1	TRIB1	0.995
FOSL1	JUN	0.995	0.367002881844
FOSL1	ATF7	0.995	0.214
STK40	ETV1	0.994
TRIB1	FOSL2	0.994
COP1	ATF7	0.992	0.15
TRIB1	FOS	0.992
FOSB	JUN	0.991
STK40	COP1	0.991
STK40	FOS	0.991
TRIB1	JUNB	0.991
ATF3	FOSL2	0.99	0.114
COP1	FOS	0.99
ATF2	FOSL2	0.989	0.092
DET1	ETV1	0.988
COP1	FOSL2	0.988	0.122
FOSB	JUND	0.986
CREB5	ATF3	0.986
FOSB	ATF2	0.985
STK40	FOSL2	0.985
FOSB	ATF7	0.983
JUNB	ATF3	0.982	0.1444
STK40	FOSL1	0.981
UBE2E1	TRIB2	0.978
DNPH1	FOSL1	0.977	0.032
UBE2E1	STK40	0.976
STK40	JUND	0.975
DET1	FOS	0.975
CREB5	FOSL2	0.974
COP1	ATF2	0.973	0.15
ATF2	ATF3	0.972	0.08
ATF7	ATF3	0.971	0.092
STK40	ATF2	0.969
FOS	ATF7	0.969
STK40	JUNB	0.967
DET1	FOSL2	0.965
FOSB	TRIB1	0.96
TRIB1	FOSL1	0.957
ROBO3	UBE2E1	0.956
UBE2E1	COP1	0.955	0.094
FOSB	COP1	0.954
STK40	ATF7	0.949
STK40	JUN	0.946
TRIB1	JUND	0.946
FOSB	STK40	0.943
TRIB1	JUN	0.929
TRIB1	ATF7	0.924
DET1	JUNB	0.92
TRIB1	ATF2	0.906
ETV5	ETV1	0.902
FOSL1	FOSL2	0.902	0.184
FOS	CREB5	0.892
FOSB	CREB5	0.877
FOSL1	CREB5	0.848
COP1	CREB5	0.644
STK40	CREB5	0.595
DNPH1	JUNB	0.587	0.022
FOSB	FOSL2	0.502
FOSB	ATF3	0.487
DET1	JUND	0.447
ETV1	TRIB1	0.418
ETV5	TRIB1	0.418
TRIB1	CREB5	0.389
DET1	CREB5	0.367
DET1	JUN	0.363
DET1	ATF2	0.359
DET1	ATF7	0.359
UBE2E1	ETV5	0.356
UBE2E1	ETV1	0.356
FOSB	FOSL1	0.214
COP1	ATF3	0.198	0.148
FOSB	DET1	0.172
STK40	ATF3	0.165
DET1	ATF3	0.164
TRIB1	ATF3	0.164
JUND	ATF3	0.164	0.126
DNPH1	JUN	0.16	0.127272727273
STK40	DNPH1	0.151
FOSL1	ATF3	0.146	0.118
DNPH1	JUND	0.129	0.032
TRIB1	DNPH1	0.127
DNPH1	ATF2	0.125	0.026
DNPH1	ATF7	0.125	0.038
COP1	DNPH1	0.095	0.044
ROBO3	FOSL1	0.071
DNPH1	FOS	0.052
ETV1	JUN	0.042
DET1	FOSL1	0.042
ETV5	JUN	0.042
DNPH1	CREB5	0.024
ROBO3	DNPH1	0.019
UBE2E1	FOSL1	0.018	0.064
UBE2E1	DNPH1	0.015	0.026
UBE2E1	ATF2	0.013	0.068
UBE2E1	ATF7	0.013	0.094
UBE2E1	JUND	0.013	0.056
UBE2E1	JUNB	0.013	0.034
UBE2E1	CREB5	0.011
UBE2E1	JUN	0.01	0.310925266904
DET1	DNPH1	0.009





Related Complexes

Genename	Complexes
ETV5	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ATF2	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
DET1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ETV1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
FOS	huMAP3_04302.1 huMAP3_09690.1 huMAP3_09842.1 huMAP3_10061.1 huMAP3_10133.1 huMAP3_12974.1 huMAP3_15260.1
FOSL2	huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
TRIB1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_11010.1 huMAP3_14027.1 huMAP3_15260.1
FOSL1	huMAP3_02914.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_12417.1 huMAP3_15260.1
CREB5	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
TRIB2	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_14660.1 huMAP3_15260.1
JUND	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
DNPH1	huMAP3_02914.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_12417.1 huMAP3_15186.1 huMAP3_15198.1
COP1	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ATF3	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
STK40	huMAP3_02750.1 huMAP3_04302.1 huMAP3_09617.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
JUN	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
FOSB	huMAP3_02665.1 huMAP3_04302.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_11678.1 huMAP3_14027.1 huMAP3_15260.1
JUNB	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
UBE2E1	huMAP3_00725.1 huMAP3_09617.1 huMAP3_10133.1 huMAP3_10166.1 huMAP3_10936.1 huMAP3_14027.1 huMAP3_15260.1
ATF7	huMAP3_04647.1 huMAP3_06833.1 huMAP3_09690.1 huMAP3_10133.1 huMAP3_15260.1
ROBO3	huMAP3_00725.1 huMAP3_09617.1 huMAP3_10133.1 huMAP3_10166.1 huMAP3_10936.1 huMAP3_13094.1