hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10134.1
Complex Portal: CPX-15723
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNF7 | Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4) | 4 | UniProt NCBI |
| ASTL | Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase) | 5 | UniProt NCBI |
| MAPK4 | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | 5 | UniProt NCBI |
| ZNF28 | Zinc finger protein 28 (Zinc finger protein KOX24) | 4 | UniProt NCBI |
| ZNF468 | Zinc finger protein 468 | 3 | UniProt NCBI |
| MAPK6 | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | 5 | UniProt NCBI |
| MAPKAPK5 | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7548 | 4.09448956317e-05 | 0.4 | MAPK6 MAPKAPK5 | MAPK6-MAPKAPK5-SEPT7 complex |
| REAC:R-HSA-5687128 | 0.000264137476094 | 0.6 | MAPK6 MAPK4 MAPKAPK5 | MAPK6/MAPK4 signaling |
| WP:WP26 | 0.00148385269311 | 0.4 | MAPK6 MAPK4 | S1P receptor signal transduction |
| REAC:R-HSA-5683057 | 0.00773441075999 | 0.6 | MAPK6 MAPK4 MAPKAPK5 | MAPK family signaling cascades |
| WP:WP4538 | 0.010328593539 | 0.4 | MAPK6 MAPK4 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:04657 | 0.0131645270498 | 0.4 | MAPK6 MAPK4 | IL-17 signaling pathway |
| WP:WP185 | 0.020275205407 | 0.4 | MAPK6 MAPK4 | Integrin mediated cell adhesion |
| WP:WP3931 | 0.0287269200827 | 0.4 | MAPK6 MAPK4 | Embryonic stem cell pluripotency pathways |
| WP:WP4787 | 0.0298851974032 | 0.4 | MAPK6 MAPK4 | Osteoblast differentiation and related diseases |
| WP:WP3915 | 0.0373080007736 | 0.4 | MAPK6 MAPK4 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP51 | 0.046989062869 | 0.4 | MAPK6 MAPK4 | Regulation of actin cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAPK6 | MAPKAPK5 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK4 | MAPK6 | 0.999 |
mutually_exclusive (Q8IW41)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAPK4 | MAPKAPK5 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ASTL | MAPK4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MAPK6 | ZNF468 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAPK6 | ZNF28 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZNF7 | MAPK6 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ASTL | MAPK6 | 0.904 | bioplex3_WMM WMM_only | ||
| ASTL | MAPKAPK5 | 0.902 | bioplex3_WMM WMM_only | ||
| ZNF28 | ZNF468 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF7 | ZNF468 | 0.768 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF7 | ZNF28 | 0.763 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF468 | MAPKAPK5 | 0.516 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF28 | MAPKAPK5 | 0.333 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF7 | MAPKAPK5 | 0.164 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes