hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10143.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VASH2 | Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein) | 5 | UniProt NCBI |
| ERI1 | 3'-5' exoribonuclease 1 (EC 3.1.-.-) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) | 5 | UniProt NCBI |
| DUSP6 | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | 5 | UniProt NCBI |
| WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | 5 | UniProt NCBI |
| NEIL1 | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9675135 | 0.0177620315324 | 0.4 | WRN NEIL1 | Diseases of DNA repair |
| CORUM:4082 | 0.0498708842806 | 0.2 | WRN | XRCC6-XRCC5-WRN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NEIL1 | DUSP6 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NEIL1 | WRN | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NEIL1 | ERI1 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NEIL1 | VASH2 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WRN | ERI1 | 0.388 | 0.116 | bioplex3_WMM WMM_only |
| WRN | VASH2 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes