hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10144.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)	5	UniProt NCBI
COL4A6	Collagen alpha-6(IV) chain	5	UniProt NCBI
COL4A4	Collagen alpha-4(IV) chain	5	UniProt NCBI
COL14A1	Collagen alpha-1(XIV) chain (Undulin)	5	UniProt NCBI
COL4A2	Collagen alpha-2(IV) chain [Cleaved into: Canstatin]	5	UniProt NCBI
FOXA1	Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1650814	5.14837835227e-10	0.833333333333	PLOD1 COL4A2 COL14A1 COL4A6 COL4A4	Collagen biosynthesis and modifying enzymes
REAC:R-HSA-1474290	2.76846766863e-09	0.833333333333	PLOD1 COL4A2 COL14A1 COL4A6 COL4A4	Collagen formation
REAC:R-HSA-8948216	3.96532736613e-08	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	Collagen chain trimerization
REAC:R-HSA-2022090	2.57601805302e-07	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-1442490	3.05932552684e-07	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	Collagen degradation
KEGG:04974	3.50709282732e-07	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	Protein digestion and absorption
REAC:R-HSA-1474244	9.63375583697e-07	0.833333333333	PLOD1 COL4A2 COL14A1 COL4A6 COL4A4	Extracellular matrix organization
REAC:R-HSA-2214320	2.01823692347e-06	0.5	COL4A4 COL4A6 COL4A2	Anchoring fibril formation
GO:0005581	3.48770721675e-06	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	collagen trimer
REAC:R-HSA-2243919	3.94996643825e-06	0.5	COL4A4 COL4A6 COL4A2	Crosslinking of collagen fibrils
REAC:R-HSA-1474228	6.85992153937e-06	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	Degradation of the extracellular matrix
GO:0030020	9.34862345773e-06	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	extracellular matrix structural constituent conferring tensile strength
GO:0005587	1.92180881975e-05	0.5	COL4A4 COL4A6 COL4A2	collagen type IV trimer
REAC:R-HSA-3000157	2.05965741212e-05	0.5	COL4A4 COL4A6 COL4A2	Laminin interactions
GO:0098651	3.84302573496e-05	0.5	COL4A4 COL4A6 COL4A2	basement membrane collagen trimer
GO:0098645	6.72425931667e-05	0.5	COL4A4 COL4A6 COL4A2	collagen network
GO:0098642	6.72425931667e-05	0.5	COL4A4 COL4A6 COL4A2	network-forming collagen trimer
WP:WP3932	8.4797283388e-05	0.666666666667	COL4A4 COL4A6 FOXA1 COL4A2	Focal adhesion PI3K Akt mTOR signaling pathway
KEGG:04512	9.43976951613e-05	0.5	COL4A4 COL4A6 COL4A2	ECM-receptor interaction
REAC:R-HSA-3000171	0.00012139707053	0.5	COL4A4 COL4A6 COL4A2	Non-integrin membrane-ECM interactions
KEGG:05146	0.000201071778007	0.5	COL4A4 COL4A6 COL4A2	Amoebiasis
KEGG:05222	0.000201071778007	0.5	COL4A4 COL4A6 COL4A2	Small cell lung cancer
KEGG:04933	0.000208220726788	0.5	COL4A4 COL4A6 COL4A2	AGE-RAGE signaling pathway in diabetic complications
REAC:R-HSA-3000178	0.000216237937074	0.5	COL4A4 COL4A6 COL4A2	ECM proteoglycans
REAC:R-HSA-216083	0.00027807877525	0.5	COL4A4 COL4A6 COL4A2	Integrin cell surface interactions
WP:WP4658	0.0003090931252	0.5	COL4A4 COL4A6 COL4A2	Small cell lung cancer
HP:0011501	0.000324079809263	0.333333333333	COL4A4 COL4A6	Anterior lenticonus
KEGG:04926	0.000399751749456	0.5	COL4A4 COL4A6 COL4A2	Relaxin signaling pathway
GO:0098644	0.000698569295426	0.5	COL4A4 COL4A6 COL4A2	complex of collagen trimers
WP:WP4239	0.00101296969036	0.5	COL4A4 COL4A6 COL4A2	Epithelial to mesenchymal transition in colorectal cancer
KEGG:04510	0.00164389422478	0.5	COL4A4 COL4A6 COL4A2	Focal adhesion
HP:0001142	0.0022669030801	0.333333333333	COL4A4 COL4A6	Lenticonus
WP:WP306	0.00227833833735	0.5	COL4A4 COL4A6 COL4A2	Focal adhesion
GO:0005201	0.00260208750266	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	extracellular matrix structural constituent
KEGG:04151	0.00734849685315	0.5	COL4A4 COL4A6 COL4A2	PI3K-Akt signaling pathway
KEGG:05165	0.00797489844932	0.5	COL4A4 COL4A6 COL4A2	Human papillomavirus infection
HP:0011526	0.00841070885474	0.333333333333	COL4A4 COL4A6	Abnormality of lens shape
WP:WP4172	0.00867989635729	0.5	COL4A4 COL4A6 COL4A2	PI3K Akt signaling pathway
REAC:R-HSA-419037	0.00902151290218	0.333333333333	COL4A4 COL4A2	NCAM1 interactions
GO:0043062	0.0136420323234	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	extracellular structure organization
GO:0030198	0.0136420323234	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	extracellular matrix organization
GO:0045229	0.0142903488279	0.666666666667	COL4A4 COL4A2 COL4A6 COL14A1	external encapsulating structure organization
GO:0005604	0.0188853212627	0.5	COL4A4 COL4A6 COL4A2	basement membrane
REAC:R-HSA-375165	0.0220691409046	0.333333333333	COL4A4 COL4A2	NCAM signaling for neurite out-growth
WP:WP5087	0.0221664611486	0.5	COL4A4 COL4A6 COL4A2	Pleural mesothelioma
KEGG:05200	0.0272817161758	0.5	COL4A4 COL4A6 COL4A2	Pathways in cancer
REAC:R-HSA-186797	0.0288812004442	0.333333333333	COL4A4 COL4A2	Signaling by PDGF
HP:0100751	0.0349615340576	0.333333333333	COL14A1 COL4A6	Esophageal neoplasm

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
COL4A4	PLOD1	0.994		bioplex3_WMM bioplex3_HCT116 WMM_only
PLOD1	COL4A6	0.988		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PLOD1	COL4A2	0.983	0.108	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
PLOD1	FOXA1	0.954	0.108	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PLOD1	COL14A1	0.951	0.14	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM
COL14A1	COL4A2	0.888	0.378	bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
COL4A6	COL4A2	0.686		bioplex_WMM bioplex3_WMM WMM_only
COL4A6	COL14A1	0.36		bioplex_WMM bioplex3_WMM WMM_only
COL4A2	FOXA1	0.22	0.11	bioplex_WMM bioplex3_WMM WMM_only
COL4A4	FOXA1	0.214		bioplex3_WMM WMM_only
COL14A1	FOXA1	0.214		bioplex_WMM bioplex3_WMM WMM_only
COL4A6	FOXA1	0.172		bioplex_WMM bioplex3_WMM WMM_only
COL4A4	COL14A1	0.107		bioplex3_WMM WMM_only
COL4A4	COL4A2	0.107		bioplex3_WMM WMM_only
COL4A4	COL4A6	0.106		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PLOD1	huMAP3_00257.1 huMAP3_04937.1 huMAP3_06617.1 huMAP3_06876.1 huMAP3_07573.1 huMAP3_08975.1 huMAP3_09570.1 huMAP3_10144.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1
COL4A6	huMAP3_00257.1 huMAP3_01891.1 huMAP3_07373.1 huMAP3_07573.1 huMAP3_08496.1 huMAP3_09570.1 huMAP3_10144.1 huMAP3_10679.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_13457.1 huMAP3_14730.1
COL4A4	huMAP3_00037.1 huMAP3_00257.1 huMAP3_02779.1 huMAP3_06014.1 huMAP3_06973.1 huMAP3_07573.1 huMAP3_08354.1 huMAP3_10095.1 huMAP3_10144.1 huMAP3_10555.1 huMAP3_10699.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
COL14A1	huMAP3_00257.1 huMAP3_06218.1 huMAP3_07573.1 huMAP3_09608.1 huMAP3_10144.1 huMAP3_10984.1 huMAP3_11663.1 huMAP3_13038.1
COL4A2	huMAP3_00257.1 huMAP3_00858.1 huMAP3_02991.1 huMAP3_04937.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10144.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
FOXA1	huMAP3_01105.1 huMAP3_09660.1 huMAP3_09708.1 huMAP3_10144.1 huMAP3_13038.1 huMAP3_14773.1 huMAP3_15027.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10144.1