hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10153.1
Complex Portal: CPX-22968
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ILVBL | 2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein) | 5 | UniProt NCBI |
| ACSL3 | Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) | 5 | UniProt NCBI |
| TYK2 | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | 5 | UniProt NCBI |
| METTL13 | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | 5 | UniProt NCBI |
| GBA2 | Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase) | 5 | UniProt NCBI |
| PCID2 | PCI domain-containing protein 2 (CSN12-like protein) | 5 | UniProt NCBI |
| DHRS13 | Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 7C member 5) (Protein SDR7C5) | 4 | UniProt NCBI |
| PFKM | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | 5 | UniProt NCBI |
| TMEM131L | Transmembrane protein 131-like | 5 | UniProt NCBI |
| INTS12 | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0301172 | 0.0123592529836 | 0.666666666667 | ILVBL ACSL3 PCID2 PFKM INTS12 METTL13 | lung; alveolar cells[>=Medium] |
| HPA:0500652 | 0.0124314519239 | 0.777777777778 | ILVBL ACSL3 PCID2 GBA2 INTS12 PFKM METTL13 | soft tissue 1; fibroblasts[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GBA2 | ILVBL | 0.999 | 0.182 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| ILVBL | INTS12 | 0.996 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| ILVBL | TMEM131L | 0.991 | 0.098 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TMEM131L | DHRS13 | 0.988 | 0.076 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| METTL13 | DHRS13 | 0.985 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ILVBL | METTL13 | 0.984 | 0.044 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PFKM | DHRS13 | 0.984 | 0.102 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TYK2 | METTL13 | 0.984 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| ILVBL | ACSL3 | 0.983 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| ACSL3 | DHRS13 | 0.979 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| METTL13 | PFKM | 0.969 | 0.036 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| PCID2 | DHRS13 | 0.968 | 0.044 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ILVBL | DHRS13 | 0.966 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ACSL3 | TMEM131L | 0.963 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| METTL13 | INTS12 | 0.961 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| METTL13 | TMEM131L | 0.92 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| METTL13 | PCID2 | 0.803 | 0.158 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ILVBL | PFKM | 0.772 | 0.152 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| PFKM | ACSL3 | 0.739 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| PFKM | TMEM131L | 0.681 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TYK2 | INTS12 | 0.645 | 0.102 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PFKM | PCID2 | 0.604 | 0.044 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| METTL13 | ACSL3 | 0.424 | 0.03 | hein_WMM bioplex_WMM bioplex3_WMM fraction | |
| TMEM131L | PCID2 | 0.353 | 0.11 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ILVBL | PCID2 | 0.335 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| GBA2 | INTS12 | 0.169 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| ILVBL | TYK2 | 0.134 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACSL3 | INTS12 | 0.133 | 0.056 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TYK2 | ACSL3 | 0.124 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| DHRS13 | INTS12 | 0.111 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only | |
| TYK2 | DHRS13 | 0.067 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| TYK2 | PFKM | 0.065 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACSL3 | PCID2 | 0.064 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PCID2 | INTS12 | 0.054 | 0.112 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PFKM | INTS12 | 0.04 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TYK2 | TMEM131L | 0.035 | 0.18 | bioplex_WMM bioplex3_WMM WMM_only | |
| TYK2 | PCID2 | 0.031 | 0.148 | bioplex_WMM bioplex3_WMM WMM_only | |
| GBA2 | DHRS13 | 0.026 | 0.1 | bioplex3_WMM WMM_only | |
| TMEM131L | INTS12 | 0.022 | 0.132 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| GBA2 | PCID2 | 0.01 | 0.058 | bioplex3_WMM WMM_only | |
| GBA2 | ACSL3 | 0.004 | 0.06 | bioplex3_HEK293 youn_WMM gupta_WMM WMM_only | |
| GBA2 | PFKM | 0.004 | 0.058 | bioplex3_HEK293 youn_WMM WMM_only |
Related Complexes