hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10161.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MTMR7 | Myotubularin-related protein 7 (Inositol 1,3-bisphosphate phosphatase) (EC 3.1.3.-) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| MTMR9 | Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9) | 5 | UniProt NCBI |
| MTMR8 | Myotubularin-related protein 8 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| MTMR6 | Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | 5 | UniProt NCBI |
| ARHGAP25 | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4971 | 1.84613378839e-08 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | Phosphoinositides metabolism |
| WP:WP5346 | 1.84613378839e-08 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | 8p23 1 copy number variation syndrome |
| REAC:R-HSA-1483255 | 4.37814665439e-07 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | PI Metabolism |
| GO:0046856 | 7.86672561549e-07 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | phosphatidylinositol dephosphorylation |
| GO:0046839 | 4.72375798258e-06 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | phospholipid dephosphorylation |
| REAC:R-HSA-1483257 | 1.63459066218e-05 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | Phospholipid metabolism |
| KEGG:00562 | 4.05033588721e-05 | 0.6 | MTMR7 MTMR8 MTMR6 | Inositol phosphate metabolism |
| REAC:R-HSA-1660499 | 5.03751582702e-05 | 0.6 | MTMR9 MTMR8 MTMR6 | Synthesis of PIPs at the plasma membrane |
| KEGG:04070 | 9.13984227268e-05 | 0.6 | MTMR7 MTMR8 MTMR6 | Phosphatidylinositol signaling system |
| GO:0004438 | 0.000274621184043 | 0.6 | MTMR7 MTMR8 MTMR6 | phosphatidylinositol-3-phosphate phosphatase activity |
| GO:0106018 | 0.000349481973524 | 0.6 | MTMR7 MTMR8 MTMR6 | phosphatidylinositol-3,5-bisphosphate phosphatase activity |
| GO:0052744 | 0.000349481973524 | 0.6 | MTMR7 MTMR8 MTMR6 | phosphatidylinositol monophosphate phosphatase activity |
| REAC:R-HSA-1660517 | 0.000835043279679 | 0.4 | MTMR7 MTMR9 | Synthesis of PIPs at the late endosome membrane |
| REAC:R-HSA-1855183 | 0.00100191474811 | 0.4 | MTMR7 MTMR9 | Synthesis of IP2, IP, and Ins in the cytosol |
| GO:0046488 | 0.00126658062664 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | phosphatidylinositol metabolic process |
| GO:0030258 | 0.0018342008752 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | lipid modification |
| GO:0034593 | 0.00194127795747 | 0.6 | MTMR7 MTMR8 MTMR6 | phosphatidylinositol bisphosphate phosphatase activity |
| REAC:R-HSA-556833 | 0.00239005722097 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | Metabolism of lipids |
| GO:0052866 | 0.00314081658857 | 0.6 | MTMR7 MTMR8 MTMR6 | phosphatidylinositol phosphate phosphatase activity |
| WP:WP5411 | 0.00503666229327 | 0.4 | MTMR8 MTMR6 | Phosphatidyl inositol phosphate pathway |
| GO:0016311 | 0.00985597470743 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | dephosphorylation |
| REAC:R-HSA-1483249 | 0.0112072433688 | 0.4 | MTMR7 MTMR9 | Inositol phosphate metabolism |
| GO:0006650 | 0.0160887636504 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | glycerophospholipid metabolic process |
| GO:0006644 | 0.0358551890782 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | phospholipid metabolic process |
| GO:0046486 | 0.0378988106089 | 0.8 | MTMR7 MTMR6 MTMR8 MTMR9 | glycerolipid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MTMR9 | MTMR6 | 1.0 | 0.582 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| MTMR9 | MTMR7 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTMR7 | MTMR6 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTMR9 | MTMR8 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTMR7 | MTMR8 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MTMR8 | ARHGAP25 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MTMR6 | MTMR8 | 0.699 | bioplex_WMM bioplex3_WMM WMM_only | |
| MTMR7 | ARHGAP25 | 0.012 | fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| MTMR7 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR9 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR8 | huMAP3_02821.1 huMAP3_10161.1 huMAP3_11523.1 |
| MTMR6 | huMAP3_01393.1 huMAP3_10161.1 huMAP3_11523.1 |
| ARHGAP25 | huMAP3_02821.1 huMAP3_10161.1 huMAP3_13459.1 |