hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10164.1
Complex Portal: CPX-15261
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EPN3 | Epsin-3 (EPS-15-interacting protein 3) | 5 | UniProt NCBI |
| PHGDH | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | 5 | UniProt NCBI |
| EPN2 | Epsin-2 (EPS-15-interacting protein 2) | 5 | UniProt NCBI |
| NUMBL | Numb-like protein (Numb-related protein) (Numb-R) | 5 | UniProt NCBI |
| CRTC2 | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | 5 | UniProt NCBI |
| PKP2 | Plakophilin-2 | 5 | UniProt NCBI |
| CRTC3 | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | 5 | UniProt NCBI |
| EPN1 | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04144 | 0.0101901500628 | 0.375 | EPN3 EPN2 EPN1 | Endocytosis |
| GO:0030125 | 0.0195375863112 | 0.375 | EPN3 EPN2 EPN1 | clathrin vesicle coat |
| REAC:R-HSA-9707616 | 0.0475081379956 | 0.25 | CRTC2 CRTC3 | Heme signaling |
| GO:0030118 | 0.0487399472212 | 0.375 | EPN3 EPN2 EPN1 | clathrin coat |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EPN1 | EPN3 | 0.999 | 0.662 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EPN2 | EPN3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| EPN3 | PHGDH | 0.999 | 0.02 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| CRTC2 | CRTC3 | 0.994 | 0.086 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| EPN2 | PHGDH | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| CRTC2 | EPN2 | 0.987 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| EPN2 | PKP2 | 0.987 | hein_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| CRTC3 | EPN2 | 0.984 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| NUMBL | EPN2 | 0.981 | hein_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | ||
| EPN1 | PHGDH | 0.974 | 0.0660601503759 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| CRTC2 | NUMBL | 0.974 | 0.132 | hein_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| CRTC2 | PKP2 | 0.966 | 0.082 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| EPN2 | EPN1 | 0.962 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| CRTC3 | PKP2 | 0.893 | 0.13 | hein_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| NUMBL | PKP2 | 0.82 | 0.056 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM | |
| CRTC2 | EPN1 | 0.796 | 0.052 | hein_WMM WMM_only | |
| NUMBL | EPN1 | 0.658 | 0.096 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| NUMBL | CRTC3 | 0.649 | 0.128 | hein_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| CRTC3 | EPN1 | 0.545 | 0.072 | hein_WMM WMM_only | |
| NUMBL | EPN3 | 0.165 | 0.042 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EPN1 | PKP2 | 0.04 | 0.048 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CRTC2 | PHGDH | 0.032 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () youn_WMM gupta_WMM | |
| PKP2 | EPN3 | 0.012 | 0.066 | gupta_WMM WMM_only | |
| PKP2 | PHGDH | 0.01 | 0.072 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only | |
| NUMBL | PHGDH | 0.006 | 0.0801823899371 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CRTC3 | PHGDH | 0.006 | 0.134 | hein_WMM bioplex3_HEK293 youn_WMM gupta_WMM boldt_WMM WMM_only |
Related Complexes