hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10180.1

Complex Portal: CPX-20260

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
GNB3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)	5	UniProt NCBI
PLEKHG5	Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)	5	UniProt NCBI
KCTD12	BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain)	4	UniProt NCBI
GNGT1	Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain)	5	UniProt NCBI
GNG2	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6391	1.53774525569e-05	0.5	KCTD12 GNG2	KCTD12-GNB1-GNG2 complex
REAC:R-HSA-416482	5.2908776296e-05	0.75	GNG2 PLEKHG5 GNGT1	G alpha (12/13) signalling events
REAC:R-HSA-8964315	0.00122873738811	0.5	GNGT1 GNG2	G beta:gamma signalling through BTK
REAC:R-HSA-392851	0.00122873738811	0.5	GNGT1 GNG2	Prostacyclin signalling through prostacyclin receptor
REAC:R-HSA-500657	0.0013924419067	0.5	GNGT1 GNG2	Presynaptic function of Kainate receptors
REAC:R-HSA-418217	0.0013924419067	0.5	GNGT1 GNG2	G beta:gamma signalling through PLC beta
REAC:R-HSA-8964616	0.00156635412759	0.5	GNGT1 GNG2	G beta:gamma signalling through CDC42
REAC:R-HSA-392170	0.00194479046925	0.5	GNGT1 GNG2	ADP signalling through P2Y purinoceptor 12
REAC:R-HSA-392451	0.00214930898727	0.5	GNGT1 GNG2	G beta:gamma signalling through PI3Kgamma
REAC:R-HSA-400042	0.00236402400204	0.5	GNGT1 GNG2	Adrenaline,noradrenaline inhibits insulin secretion
REAC:R-HSA-202040	0.00236402400204	0.5	GNGT1 GNG2	G-protein activation
REAC:R-HSA-451326	0.00236402400204	0.5	GNGT1 GNG2	Activation of kainate receptors upon glutamate binding
REAC:R-HSA-428930	0.00236402400204	0.5	GNGT1 GNG2	Thromboxane signalling through TP receptor
REAC:R-HSA-418592	0.00236402400204	0.5	GNGT1 GNG2	ADP signalling through P2Y purinoceptor 1
REAC:R-HSA-1296041	0.00258893271292	0.5	GNGT1 GNG2	Activation of G protein gated Potassium channels
REAC:R-HSA-997272	0.00258893271292	0.5	GNGT1 GNG2	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REAC:R-HSA-420092	0.00258893271292	0.5	GNGT1 GNG2	Glucagon-type ligand receptors
REAC:R-HSA-1296059	0.00258893271292	0.5	GNGT1 GNG2	G protein gated Potassium channels
REAC:R-HSA-1296065	0.00359044851421	0.5	GNGT1 GNG2	Inwardly rectifying K+ channels
REAC:R-HSA-456926	0.00359044851421	0.5	GNGT1 GNG2	Thrombin signalling through proteinase activated receptors (PARs)
REAC:R-HSA-397795	0.00359044851421	0.5	GNGT1 GNG2	G-protein beta:gamma signalling
REAC:R-HSA-392518	0.00444848198459	0.5	GNGT1 GNG2	Signal amplification
KEGG:05200	0.0049271234807	0.75	GNG2 PLEKHG5 GNGT1	Pathways in cancer
REAC:R-HSA-977444	0.00539805716719	0.5	GNGT1 GNG2	GABA B receptor activation
REAC:R-HSA-991365	0.00539805716719	0.5	GNGT1 GNG2	Activation of GABAB receptors
KEGG:04727	0.00551283411821	0.5	GNGT1 GNG2	GABAergic synapse
KEGG:05032	0.0056793701001	0.5	GNGT1 GNG2	Morphine addiction
REAC:R-HSA-432040	0.00573491177379	0.5	GNGT1 GNG2	Vasopressin regulates renal water homeostasis via Aquaporins
REAC:R-HSA-9660821	0.006081926491	0.5	GNGT1 GNG2	ADORA2B mediated anti-inflammatory cytokines production
REAC:R-HSA-6814122	0.006081926491	0.5	GNGT1 GNG2	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
REAC:R-HSA-418597	0.006081926491	0.5	GNGT1 GNG2	G alpha (z) signalling events
REAC:R-HSA-381676	0.006081926491	0.5	GNGT1 GNG2	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REAC:R-HSA-9634597	0.00643909852192	0.5	GNGT1 GNG2	GPER1 signaling
REAC:R-HSA-445717	0.00643909852192	0.5	GNGT1 GNG2	Aquaporin-mediated transport
KEGG:04713	0.00654897197861	0.5	GNGT1 GNG2	Circadian entrainment
KEGG:04724	0.00806816574582	0.5	GNGT1 GNG2	Glutamatergic synapse
REAC:R-HSA-977443	0.00837722051003	0.5	GNGT1 GNG2	GABA receptor activation
KEGG:04726	0.00867836513934	0.5	GNGT1 GNG2	Serotonergic synapse
KEGG:04725	0.00974438450458	0.5	GNGT1 GNG2	Cholinergic synapse
REAC:R-HSA-388396	0.0112517828268	0.75	GNG2 PLEKHG5 GNGT1	GPCR downstream signalling
REAC:R-HSA-4086398	0.0140623832262	0.5	GNGT1 GNG2	Ca2+ pathway
KEGG:04926	0.014352694406	0.5	GNGT1 GNG2	Relaxin signaling pathway
KEGG:04728	0.014619629343	0.5	GNGT1 GNG2	Dopaminergic synapse
KEGG:04371	0.015160801965	0.5	GNGT1 GNG2	Apelin signaling pathway
WP:WP536	0.015715675352	0.5	GNGT1 GNG2	Calcium regulation in cardiac cells
REAC:R-HSA-372790	0.0165968987372	0.75	GNG2 PLEKHG5 GNGT1	Signaling by GPCR
KEGG:04723	0.017422762868	0.5	GNGT1 GNG2	Retrograde endocannabinoid signaling
WP:WP3929	0.0183400443465	0.5	GNGT1 GNG2	Chemokine signaling pathway
REAC:R-HSA-9009391	0.019281632575	0.5	GNGT1 GNG2	Extra-nuclear estrogen signaling
REAC:R-HSA-9664433	0.019281632575	0.5	GNGT1 GNG2	Leishmania parasite growth and survival
REAC:R-HSA-9662851	0.019281632575	0.5	GNGT1 GNG2	Anti-inflammatory response favouring Leishmania parasite infection
REAC:R-HSA-422356	0.0212029570934	0.5	GNGT1 GNG2	Regulation of insulin secretion
WP:WP289	0.0214906806331	0.5	GNGT1 GNG2	Myometrial relaxation and contraction pathways
REAC:R-HSA-1296071	0.0218635493976	0.5	GNGT1 GNG2	Potassium Channels
REAC:R-HSA-373080	0.0232149434748	0.5	GNGT1 GNG2	Class B/2 (Secretin family receptors)
KEGG:04062	0.0237566589162	0.5	GNGT1 GNG2	Chemokine signaling pathway
CORUM:7149	0.0249718442456	0.25	GNG2	GNAS-L-GNB3-GNG2 complex
CORUM:7144	0.0249718442456	0.25	GNGT1	GNAS-L-GNB3-GNG1 complex
REAC:R-HSA-418346	0.0260384914588	0.5	GNGT1 GNG2	Platelet homeostasis
WP:WP4223	0.0270438297073	0.5	GNGT1 GNG2	Ras signaling
KEGG:05034	0.0272860662684	0.5	GNGT1 GNG2	Alcoholism
REAC:R-HSA-111885	0.0305753786405	0.5	GNGT1 GNG2	Opioid Signalling
KEGG:05167	0.0346546128597	0.5	GNGT1 GNG2	Kaposi sarcoma-associated herpesvirus infection
REAC:R-HSA-390466	0.0363250695065	0.5	GNGT1 GNG2	Chaperonin-mediated protein folding
KEGG:04014	0.0415303647194	0.5	GNGT1 GNG2	Ras signaling pathway
REAC:R-HSA-163685	0.041644107744	0.5	GNGT1 GNG2	Integration of energy metabolism
REAC:R-HSA-418555	0.0425656343513	0.5	GNGT1 GNG2	G alpha (s) signalling events
REAC:R-HSA-391251	0.0425656343513	0.5	GNGT1 GNG2	Protein folding
KEGG:05163	0.0451972531521	0.5	GNGT1 GNG2	Human cytomegalovirus infection
KEGG:05170	0.0456663239038	0.5	GNGT1 GNG2	Human immunodeficiency virus 1 infection
CORUM:7021	0.049938562206	0.25	GNG2	GNAI1-GNB3-GNG2 complex
CORUM:7097	0.049938562206	0.25	GNGT1	GNAS-L-GNB1-GNG1 complex
CORUM:7143	0.049938562206	0.25	GNGT1	GNAS-L-GNB2-GNG1 complex
CORUM:1614	0.049938562206	0.25	GNG2	G protein complex (MCF2, GNB1, GNG2)
CORUM:7145	0.049938562206	0.25	GNGT1	GNAS-L-GNB4-GNG1 complex
CORUM:7146	0.049938562206	0.25	GNGT1	GNAS-L-GNB1-GNG1 complex
CORUM:7147	0.049938562206	0.25	GNG2	GNAS-L-GNB1-GNG2 complex
CORUM:7148	0.049938562206	0.25	GNG2	GNAS-L-GNB2-GNG2 complex
CORUM:7150	0.049938562206	0.25	GNG2	GNAS-L-GNB4-GNG2 complex
CORUM:7151	0.049938562206	0.25	GNG2	GNAS-L-GNB4-GNG2 complex
CORUM:7016	0.049938562206	0.25	GNGT1	GNAI1-GNB3-GNGT1 complex
CORUM:1612	0.049938562206	0.25	GNG2	GNAS-GNB1-GNG2 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
PLEKHG5	GNG2	0.993			bioplex3_WMM bioplex3_HCT116 WMM_only
GNG2	KCTD12	0.992	0.114545454545		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GNG2	GNB3	0.986	0.23	structurally_consistent (P62873) structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GNB3	GNGT1	0.981		structurally_consistent (P62873) structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
PLEKHG5	GNB3	0.673			bioplex3_WMM WMM_only
PLEKHG5	KCTD12	0.645			bioplex3_WMM WMM_only
KCTD12	GNB3	0.354	0.086		bioplex_WMM bioplex3_WMM WMM_only
KCTD12	GNGT1	0.061			bioplex3_HEK293 WMM_only

Related Complexes

Genename	Complexes
GNB3	huMAP3_07745.1 huMAP3_08586.1 huMAP3_09174.1 huMAP3_09788.1 huMAP3_10180.1 huMAP3_10236.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12374.1 huMAP3_12474.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
PLEKHG5	huMAP3_00362.1 huMAP3_01841.1 huMAP3_05451.1 huMAP3_07596.1 huMAP3_08480.1 huMAP3_09174.1 huMAP3_09810.1 huMAP3_10180.1 huMAP3_10808.1 huMAP3_12897.1
KCTD12	huMAP3_01791.1 huMAP3_01841.1 huMAP3_05128.1 huMAP3_07060.1 huMAP3_10180.1 huMAP3_10867.1 huMAP3_12427.1
GNGT1	huMAP3_07745.1 huMAP3_08586.1 huMAP3_09174.1 huMAP3_09185.1 huMAP3_10180.1 huMAP3_10236.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12474.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG2	huMAP3_00875.1 huMAP3_01144.1 huMAP3_01841.1 huMAP3_05451.1 huMAP3_09174.1 huMAP3_10180.1 huMAP3_10236.1 huMAP3_11173.1 huMAP3_11626.1 huMAP3_13105.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10180.1

Complex Portal: CPX-20260