hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10181.1
Complex Portal: CPX-24424
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LTBP3 | Latent-transforming growth factor beta-binding protein 3 (LTBP-3) | 5 | UniProt NCBI |
| FBLN5 | Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50) | 5 | UniProt NCBI |
| DNAJC10 | DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr) | 5 | UniProt NCBI |
| DSTYK | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | 5 | UniProt NCBI |
| PTRH2 | Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1) | 5 | UniProt NCBI |
| EGFL7 | Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000762 | 0.00390912678804 | 0.5 | FBLN5 LTBP3 PTRH2 | Decreased nerve conduction velocity |
| HP:0040129 | 0.00443283482612 | 0.5 | FBLN5 LTBP3 PTRH2 | Abnormal nerve conduction velocity |
| HP:0003134 | 0.0075592305979 | 0.5 | FBLN5 LTBP3 PTRH2 | Abnormality of peripheral nerve conduction |
| REAC:R-HSA-2129379 | 0.0104313293282 | 0.333333333333 | FBLN5 LTBP3 | Molecules associated with elastic fibres |
| HP:0030177 | 0.0129601794289 | 0.5 | FBLN5 LTBP3 PTRH2 | Abnormality of peripheral nervous system electrophysiology |
| HP:0032120 | 0.0138111776458 | 0.5 | FBLN5 LTBP3 PTRH2 | Abnormal peripheral nervous system physiology |
| REAC:R-HSA-1566948 | 0.0161658624528 | 0.333333333333 | FBLN5 LTBP3 | Elastic fibre formation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DNAJC10 | EGFL7 | 0.986 | 0.092 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DNAJC10 | LTBP3 | 0.971 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PTRH2 | DSTYK | 0.968 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FBLN5 | DNAJC10 | 0.96 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DSTYK | EGFL7 | 0.952 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PTRH2 | EGFL7 | 0.943 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FBLN5 | EGFL7 | 0.8 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| FBLN5 | LTBP3 | 0.769 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| LTBP3 | EGFL7 | 0.689 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| DSTYK | DNAJC10 | 0.053 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| DSTYK | LTBP3 | 0.027 | 0.068 | bioplex3_WMM WMM_only | |
| PTRH2 | DNAJC10 | 0.014 | 0.132 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| PTRH2 | LTBP3 | 0.005 | 0.054 | bioplex3_WMM WMM_only |
Related Complexes