hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10195.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
FADS2	Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2)	5	UniProt NCBI
ATP12A	Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump)	5	UniProt NCBI
ATP1B1	Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)	5	UniProt NCBI
NDRG3	Protein NDRG3 (N-myc downstream-regulated gene 3 protein)	3	UniProt NCBI
ATP1B3	Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)	5	UniProt NCBI
MAIP1	m-AAA protease-interacting protein 1, mitochondrial (Matrix AAA peptidase-interacting protein 1)	5	UniProt NCBI
ADGRL2	Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-936837	0.000109213310364	0.428571428571	ATP12A ATP1B1 ATP1B3	Ion transport by P-type ATPases
GO:0030007	0.00040312426486	0.428571428571	ATP12A ATP1B1 ATP1B3	intracellular potassium ion homeostasis
GO:0036376	0.000738757615619	0.428571428571	ATP12A ATP1B1 ATP1B3	sodium ion export across plasma membrane
GO:0090533	0.00152694380207	0.428571428571	ATP12A ATP1B1 ATP1B3	cation-transporting ATPase complex
GO:0006883	0.00152694380207	0.428571428571	ATP12A ATP1B1 ATP1B3	intracellular sodium ion homeostasis
KEGG:04964	0.0019420290898	0.285714285714	ATP1B1 ATP1B3	Proximal tubule bicarbonate reclamation
GO:0055075	0.00273674384085	0.428571428571	ATP12A ATP1B1 ATP1B3	potassium ion homeostasis
GO:0098533	0.00382182132582	0.428571428571	ATP12A ATP1B1 ATP1B3	ATPase dependent transmembrane transport complex
REAC:R-HSA-983712	0.00394439973206	0.428571428571	ATP12A ATP1B1 ATP1B3	Ion channel transport
KEGG:04960	0.0044360875468	0.285714285714	ATP1B1 ATP1B3	Aldosterone-regulated sodium reabsorption
GO:0055078	0.00516068999797	0.428571428571	ATP12A ATP1B1 ATP1B3	sodium ion homeostasis
KEGG:04973	0.00606082987148	0.285714285714	ATP1B1 ATP1B3	Carbohydrate digestion and absorption
REAC:R-HSA-210991	0.00721110026367	0.285714285714	ATP1B1 ATP1B3	Basigin interactions
REAC:R-HSA-382551	0.0108683135939	0.571428571429	MAIP1 ATP12A ATP1B1 ATP1B3	Transport of small molecules
KEGG:04961	0.0109812266458	0.285714285714	ATP1B1 ATP1B3	Endocrine and other factor-regulated calcium reabsorption
KEGG:04978	0.0109812266458	0.285714285714	ATP1B1 ATP1B3	Mineral absorption
KEGG:04971	0.0139791020136	0.285714285714	ATP1B1 ATP1B3	Gastric acid secretion
GO:1990573	0.0150353457168	0.428571428571	ATP12A ATP1B1 ATP1B3	potassium ion import across plasma membrane
KEGG:04976	0.0167496959508	0.285714285714	ATP1B1 ATP1B3	Bile secretion
KEGG:04918	0.0179270542228	0.285714285714	ATP1B1 ATP1B3	Thyroid hormone synthesis
KEGG:04970	0.0203999615702	0.285714285714	ATP1B1 ATP1B3	Salivary secretion
KEGG:04911	0.0210427715268	0.285714285714	ATP1B1 ATP1B3	Insulin secretion
KEGG:04974	0.0237121385349	0.285714285714	ATP1B1 ATP1B3	Protein digestion and absorption
KEGG:04260	0.0258170059595	0.285714285714	ATP1B1 ATP1B3	Cardiac muscle contraction
KEGG:04972	0.0258170059595	0.285714285714	ATP1B1 ATP1B3	Pancreatic secretion
KEGG:04925	0.0272691209555	0.285714285714	ATP1B1 ATP1B3	Aldosterone synthesis and secretion
GO:1903288	0.0294899169624	0.285714285714	ATP1B1 ATP1B3	positive regulation of potassium ion import across plasma membrane
REAC:R-HSA-5578775	0.030972755234	0.285714285714	ATP1B1 ATP1B3	Ion homeostasis

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
ATP12A	ATP1B1	0.996		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
ATP1B3	ATP12A	0.994		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
ADGRL2	ATP1B3	0.989	0.118	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM
ATP1B3	ATP1B1	0.986	0.168	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM
FADS2	ATP1B3	0.984	0.104	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM
NDRG3	ATP1B1	0.979	0.016	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
MAIP1	ATP1B1	0.966	0.012	bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only
NDRG3	ATP1B3	0.964	0.016	bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
FADS2	ATP1B1	0.71	0.116	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
ATP1B3	MAIP1	0.606	0.064	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM
ADGRL2	ATP1B1	0.464	0.082	bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
FADS2	ATP12A	0.382		bioplex_WMM bioplex3_WMM WMM_only
NDRG3	ATP12A	0.228		bioplex3_WMM WMM_only
ADGRL2	FADS2	0.202	0.076	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
ADGRL2	MAIP1	0.121	0.058	bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only
ADGRL2	ATP12A	0.118		bioplex_WMM bioplex3_WMM WMM_only
FADS2	MAIP1	0.065	0.044	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NDRG3	FADS2	0.051	0.024	bioplex3_WMM youn_WMM WMM_only
NDRG3	ADGRL2	0.042	0.04	bioplex3_WMM WMM_only
NDRG3	MAIP1	0.025	0.032	bioplex3_WMM WMM_only
MAIP1	ATP12A	0.02		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
FADS2	huMAP3_01819.1 huMAP3_02584.1 huMAP3_05445.1 huMAP3_06361.1 huMAP3_06842.1 huMAP3_07941.1 huMAP3_08115.1 huMAP3_10195.1
ATP12A	huMAP3_04972.1 huMAP3_06361.1 huMAP3_07575.1 huMAP3_10195.1 huMAP3_11165.1
ATP1B1	huMAP3_04972.1 huMAP3_07108.1 huMAP3_07410.1 huMAP3_08156.1 huMAP3_09007.1 huMAP3_09189.1 huMAP3_09747.1 huMAP3_10195.1 huMAP3_12258.1
NDRG3	huMAP3_00533.1 huMAP3_04972.1 huMAP3_06361.1 huMAP3_06522.1 huMAP3_07108.1 huMAP3_07960.1 huMAP3_09007.1 huMAP3_09189.1 huMAP3_09747.1 huMAP3_10195.1 huMAP3_12258.1 huMAP3_13561.1 huMAP3_13756.1
ATP1B3	huMAP3_02584.1 huMAP3_06361.1 huMAP3_06522.1 huMAP3_06791.1 huMAP3_10195.1 huMAP3_13561.1
MAIP1	huMAP3_03315.1 huMAP3_04972.1 huMAP3_05462.1 huMAP3_07108.1 huMAP3_08156.1 huMAP3_08619.1 huMAP3_09889.1 huMAP3_10008.1 huMAP3_10195.1
ADGRL2	huMAP3_01059.1 huMAP3_02584.1 huMAP3_06275.1 huMAP3_06361.1 huMAP3_07853.1 huMAP3_10195.1 huMAP3_12150.1 huMAP3_14838.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10195.1