hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10205.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIX2 | Homeobox protein SIX2 (Sine oculis homeobox homolog 2) | 5 | UniProt NCBI |
| EYA1 | Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) | 5 | UniProt NCBI |
| EYA4 | Eyes absent homolog 4 (EC 3.1.3.48) | 5 | UniProt NCBI |
| SIX1 | Homeobox protein SIX1 (Sine oculis homeobox homolog 1) | 5 | UniProt NCBI |
| ERCC6L | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7363 | 1.36501667663e-05 | 0.4 | EYA1 SIX1 | EYA1-SIX1 complex |
| CORUM:7364 | 1.36501667663e-05 | 0.4 | SIX2 EYA1 | EYA1-SIX2 complex |
| WP:WP5236 | 1.94918954111e-05 | 0.6 | SIX1 SIX2 EYA1 | Markers of kidney cell lineage |
| WP:WP5053 | 1.94918954111e-05 | 0.6 | SIX1 SIX2 EYA1 | Development of ureteric collection system |
| HP:0011388 | 0.000384717178033 | 0.4 | EYA1 SIX1 | Enlarged cochlear aqueduct |
| HP:0009798 | 0.000384717178033 | 0.4 | EYA1 SIX1 | Euthyroid goiter |
| HP:0004458 | 0.000384717178033 | 0.4 | EYA1 SIX1 | Dilatated internal auditory canal |
| HP:0100274 | 0.000641107533884 | 0.4 | EYA1 SIX1 | Gustatory lacrimation |
| HP:0009796 | 0.000961529670085 | 0.4 | EYA1 SIX1 | Branchial cyst |
| HP:0011387 | 0.001345957274 | 0.4 | EYA1 SIX1 | Enlarged vestibular aqueduct |
| HP:0008586 | 0.001345957274 | 0.4 | EYA1 SIX1 | Hypoplasia of the cochlea |
| HP:0000376 | 0.001345957274 | 0.4 | EYA1 SIX1 | Incomplete partition of the cochlea type II |
| HP:0009797 | 0.00179436403841 | 0.4 | EYA1 SIX1 | Cholesteatoma |
| HP:0100799 | 0.00179436403841 | 0.4 | EYA1 SIX1 | Neoplasm of the middle ear |
| HP:0011395 | 0.00179436403841 | 0.4 | EYA1 SIX1 | Aplasia/Hypoplasia of the cochlea |
| HP:0004712 | 0.00179436403841 | 0.4 | EYA1 SIX1 | Renal malrotation |
| HP:0011373 | 0.00179436403841 | 0.4 | EYA1 SIX1 | Incomplete partition of the cochlea |
| HP:0008554 | 0.00230672366147 | 0.4 | EYA1 SIX1 | Cochlear malformation |
| HP:0008774 | 0.00230672366147 | 0.4 | EYA1 SIX1 | Aplasia/Hypoplasia of the inner ear |
| HP:0011094 | 0.00288300984678 | 0.4 | EYA1 SIX1 | Increased overbite |
| HP:0009795 | 0.00288300984678 | 0.4 | EYA1 SIX1 | Branchial fistula |
| HP:0000799 | 0.00288300984678 | 0.4 | EYA1 SIX1 | Renal steatosis |
| HP:0007925 | 0.00288300984678 | 0.4 | EYA1 SIX1 | Lacrimal duct aplasia |
| WP:WP4823 | 0.00328532749654 | 0.4 | EYA1 SIX1 | Genes controlling nephrogenesis |
| HP:0100267 | 0.0035231963033 | 0.4 | EYA1 SIX1 | Lip pit |
| HP:0007678 | 0.00582689447108 | 0.4 | EYA1 SIX1 | Lacrimal duct stenosis |
| HP:0009794 | 0.00979150178217 | 0.4 | EYA1 SIX1 | Branchial anomaly |
| HP:0004452 | 0.00979150178217 | 0.4 | EYA1 SIX1 | Abnormality of the middle ear ossicles |
| HP:0011384 | 0.0109419445801 | 0.4 | EYA1 SIX1 | Abnormality of the internal auditory canal |
| HP:0000074 | 0.0109419445801 | 0.4 | EYA1 SIX1 | Ureteropelvic junction obstruction |
| HP:0012780 | 0.0109419445801 | 0.4 | EYA1 SIX1 | Neoplasm of the ear |
| HP:0011376 | 0.0207761643339 | 0.4 | EYA1 SIX1 | Abnormal morphology of the vestibule of the inner ear |
| HP:0008609 | 0.0207761643339 | 0.4 | EYA1 SIX1 | Abnormal middle ear morphology |
| HP:0000375 | 0.0224351839587 | 0.4 | EYA1 SIX1 | Abnormal cochlea morphology |
| HP:0000071 | 0.0224351839587 | 0.4 | EYA1 SIX1 | Ureteral stenosis |
| HP:0000579 | 0.0259435594648 | 0.4 | EYA1 SIX1 | Nasolacrimal duct obstruction |
| HP:0004742 | 0.0259435594648 | 0.4 | EYA1 SIX1 | Abnormal renal collecting system morphology |
| HP:0000402 | 0.0277928629638 | 0.4 | EYA1 SIX1 | Stenosis of the external auditory canal |
| HP:0000410 | 0.0337209222644 | 0.4 | EYA1 SIX1 | Mixed hearing impairment |
| HP:0006000 | 0.0337209222644 | 0.4 | EYA1 SIX1 | Ureteral obstruction |
| REAC:R-HSA-5693565 | 0.0374197925333 | 0.4 | EYA1 EYA4 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0384836492499 | 0.4 | EYA1 EYA4 | DNA Double Strand Break Response |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SIX2 | ERCC6L | 0.999 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SIX2 | EYA4 | 0.99 | 0.25 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EYA1 | SIX1 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SIX1 | ERCC6L | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA1 | SIX2 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA4 | SIX1 | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EYA1 | EYA4 | 0.528 | bioplex_WMM bioplex3_WMM WMM_only | |
| EYA1 | ERCC6L | 0.216 | bioplex_WMM bioplex3_WMM WMM_only | |
| SIX2 | SIX1 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | |
| EYA4 | ERCC6L | 0.088 | 0.106 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes