hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10212.1

Complex Portal: CPX-24116

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
TMEM160	Transmembrane protein 160	2	UniProt NCBI
KCNMB2	Calcium-activated potassium channel subunit beta-2 (BK channel subunit beta-2) (BKbeta2) (Hbeta2) (Calcium-activated potassium channel, subfamily M subunit beta-2) (Charybdotoxin receptor subunit beta-2) (Hbeta3) (K(VCA)beta-2) (Maxi K channel subunit beta-2) (Slo-beta-2)	5	UniProt NCBI
KBTBD7	Kelch repeat and BTB domain-containing protein 7	5	UniProt NCBI
PRKCZ	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)	5	UniProt NCBI
PARD6G	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)	5	UniProt NCBI
LLGL1	Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)	5	UniProt NCBI
LLGL2	LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)	5	UniProt NCBI
RGL1	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)	4	UniProt NCBI
PARD3	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	5	UniProt NCBI
ZNF3	Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25)	5	UniProt NCBI
PRKCI	Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)	5	UniProt NCBI
NIPSNAP2	Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence)	5	UniProt NCBI
PTPN21	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)	5	UniProt NCBI
PARD6B	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)	5	UniProt NCBI
PARD6A	Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)	5	UniProt NCBI
SQSTM1	Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)	5	UniProt NCBI
TEFM	Transcription elongation factor, mitochondrial	5	UniProt NCBI
BEGAIN	Brain-enriched guanylate kinase-associated protein	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0120157	4.57652326261e-14	0.352941176471	PARD6G PARD6B PARD3 PARD6A PRKCI PRKCZ	PAR polarity complex
GO:0045197	1.13478526156e-12	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	establishment or maintenance of epithelial cell apical/basal polarity
GO:0061245	2.21351033406e-12	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	establishment or maintenance of bipolar cell polarity
GO:0035088	2.21351033406e-12	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	establishment or maintenance of apical/basal cell polarity
KEGG:04530	7.45384833999e-11	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	Tight junction
KEGG:04390	1.11110471481e-10	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	Hippo signaling pathway
WP:WP5090	5.13699675169e-10	0.411764705882	PARD6G LLGL2 PARD6B PRKCZ PARD6A PRKCI PARD3	Complement system in neuronal development and plasticity
REAC:R-HSA-420029	1.07214655238e-09	0.294117647059	PARD6G PARD6A PARD3 PARD6B PRKCI	Tight junction interactions
KEGG:05165	3.05578074937e-08	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	Human papillomavirus infection
CORUM:956	5.58646392581e-08	0.176470588235	PARD6B PARD3 PRKCI	PAR-3-PAR-6B-PRKCI complex
CORUM:959	5.58646392581e-08	0.176470588235	LLGL1 PRKCI PARD6B	LLGL1-PAR-6B-PRKCI complex
CORUM:955	5.58646392581e-08	0.176470588235	PARD6B LLGL2 PRKCI	LLGL2-PAR-6B-PRKCI complex
GO:0007163	1.5761895989e-07	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	establishment or maintenance of cell polarity
CORUM:7444	2.23297982515e-07	0.176470588235	PARD6A PARD3 PRKCI	HOOK2-PAR3-Par6alpha-PKCiota complex
REAC:R-HSA-421270	4.2732177246e-07	0.294117647059	PARD6G PARD6A PARD3 PARD6B PRKCI	Cell-cell junction organization
CORUM:905	5.57843805733e-07	0.176470588235	PARD6A PARD3 PRKCI	KIF3A/B-PAR-3-aPKC-PAR-6 complex
KEGG:04015	1.32003669281e-06	0.352941176471	PARD6G PARD6B PARD3 PARD6A PRKCI PRKCZ	Rap1 signaling pathway
REAC:R-HSA-446728	4.80385368045e-06	0.294117647059	PARD6G PARD6A PARD3 PARD6B PRKCI	Cell junction organization
GO:0070160	5.75732312025e-06	0.352941176471	PARD6G PARD6B PARD3 PARD6A PRKCI PRKCZ	tight junction
KEGG:04144	9.42927415851e-06	0.352941176471	PARD6G PARD6B PARD3 PARD6A PRKCI PRKCZ	Endocytosis
REAC:R-HSA-1500931	2.9423150637e-05	0.294117647059	PARD6G PARD6A PARD3 PARD6B PRKCI	Cell-Cell communication
GO:0005911	3.30257709052e-05	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	cell-cell junction
KEGG:04360	4.10164635109e-05	0.294117647059	PARD6G PARD6A PRKCZ PARD6B PARD3	Axon guidance
CORUM:7300	0.000163158265417	0.117647058824	PARD6A PRKCI	PARD3B-PARD6A-PRKCI complex
CORUM:831	0.000163158265417	0.117647058824	PARD6A PARD3	PAR-6-PAR-3-VE-cadherin complex, endothelial
CORUM:847	0.000163158265417	0.117647058824	PARD3 PRKCI	RICH1-PAR3-aPKC polarity complex
CORUM:918	0.000163158265417	0.117647058824	PARD6A PARD3	PAR3-PAR6-PALS1 complex
CORUM:6933	0.000163158265417	0.117647058824	PRKCZ SQSTM1	PRKCZ-SQSTM-TRAF6 complex
CORUM:5535	0.000163158265417	0.117647058824	PARD6A PARD3	PLCB3-PARD3-PARD6A complex
CORUM:2143	0.000163158265417	0.117647058824	PRKCI SQSTM1	MAP2K5-PRKCI-SQSTM1 complex
CORUM:5534	0.000163158265417	0.117647058824	PARD6A PARD3	PLCB1-PARD3-PARD6A complex
REAC:R-HSA-2173791	0.000190219979592	0.176470588235	PARD6A PRKCZ PARD3	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
GO:1902554	0.000208553176975	0.352941176471	PARD6G PARD6B PARD3 PARD6A PRKCI PRKCZ	serine/threonine protein kinase complex
GO:1902911	0.000447233973403	0.352941176471	PARD6G PARD6B PARD3 PARD6A PRKCI PRKCZ	protein kinase complex
GO:0005938	0.00145001188916	0.352941176471	PARD6G LLGL2 LLGL1 PARD6B PARD6A PARD3	cell cortex
WP:WP5381	0.00198009792691	0.235294117647	LLGL1 PARD3 PARD6B PRKCI	Smith Magenis and Potocki Lupski syndrome copy number variation
WP:WP3656	0.00647668412102	0.117647058824	PRKCZ SQSTM1	Interleukin 1 induced activation of NF kB
GO:0070161	0.00805464039984	0.470588235294	PARD6G LLGL2 PARD6A PARD6B PRKCZ LLGL1 PRKCI PARD3	anchoring junction
REAC:R-HSA-209543	0.0183854258919	0.117647058824	PRKCI SQSTM1	p75NTR recruits signalling complexes
GO:0061695	0.0223212796651	0.352941176471	PARD6G PARD6B PARD3 PARD6A PRKCI PRKCZ	transferase complex, transferring phosphorus-containing groups
REAC:R-HSA-193639	0.0318027124492	0.117647058824	PRKCI SQSTM1	p75NTR signals via NF-kB
REAC:R-HSA-170834	0.0420770759522	0.176470588235	PARD6A PRKCZ PARD3	Signaling by TGF-beta Receptor Complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PRKCI	PARD6B	1.0	0.106	structurally_consistent (dimer)
PARD6B	LLGL2	1.0	0.184
LLGL1	PARD6B	1.0	0.12
PRKCZ	PARD6B	1.0	0.168	structurally_consistent (dimer)
PRKCI	LLGL2	1.0	0.048
PARD6A	LLGL2	1.0
PRKCI	LLGL1	0.999	0.108
PARD6G	LLGL2	0.999
PRKCI	PRKCZ	0.999	0.336	mutually_exclusive (Q9BYG5)
PARD6A	PRKCZ	0.999		structurally_consistent (dimer)
PARD6G	PRKCZ	0.999		structurally_consistent (dimer)
KBTBD7	TEFM	0.999	0.138
PARD3	PARD6B	0.998	0.116
SQSTM1	TMEM160	0.998	0.202
PARD6G	PARD6B	0.998
KBTBD7	PARD6B	0.998	0.184
PRKCZ	LLGL2	0.998	0.124
LLGL1	LLGL2	0.997	0.0501219512195
PRKCZ	LLGL1	0.997	0.094	structurally_consistent (dimer)
NIPSNAP2	TMEM160	0.996	0.054
PRKCI	PARD6G	0.995
KBTBD7	LLGL2	0.993	0.092
PRKCZ	BEGAIN	0.993
PTPN21	PARD6B	0.991	0.158	mutually_exclusive (Q9NPB6)
KBTBD7	TMEM160	0.99	0.08
NIPSNAP2	SQSTM1	0.987	0.224
PARD3	LLGL2	0.986	0.03
PRKCZ	NIPSNAP2	0.984	0.268	structurally_consistent (dimer)
KBTBD7	PRKCI	0.983	0.098
PARD3	PRKCI	0.983	0.068
PRKCI	TMEM160	0.982	0.052
PRKCI	NIPSNAP2	0.979	0.044
ZNF3	LLGL1	0.978	0.082
PRKCZ	SQSTM1	0.974	0.332689655172	structurally_consistent (dimer)
KBTBD7	PRKCZ	0.974	0.196
KBTBD7	LLGL1	0.964	0.124
ZNF3	PARD6B	0.962	0.096
PRKCI	PARD6A	0.959
TMEM160	KCNMB2	0.958
PARD6A	PARD6B	0.957		structurally_consistent (dimer)
PARD6A	NIPSNAP2	0.955
PRKCI	SQSTM1	0.954	0.21
ZNF3	PRKCI	0.952	0.098
LLGL2	RGL1	0.951
ZNF3	NIPSNAP2	0.95	0.08
LLGL1	NIPSNAP2	0.949	0.07
PARD6A	TMEM160	0.941
PARD6A	BEGAIN	0.902
PARD3	PRKCZ	0.893	0.14
PARD6G	PARD6A	0.887		mutually_exclusive (Q05513)
KBTBD7	PARD6G	0.88
ZNF3	TMEM160	0.871	0.054
PARD3	LLGL1	0.864	0.034
PARD6A	LLGL1	0.862		mutually_exclusive (Q05513)
PARD6G	LLGL1	0.815
LLGL2	TMEM160	0.812	0.056
LLGL2	NIPSNAP2	0.775	0.072
PRKCZ	TMEM160	0.77	0.208
KBTBD7	PARD6A	0.769
PARD6B	SQSTM1	0.734	0.170633540373
PARD6G	BEGAIN	0.676
TEFM	PARD6B	0.64	0.058
LLGL1	TMEM160	0.612	0.086
PARD6G	TMEM160	0.591
PARD6A	RGL1	0.572
PARD6A	SQSTM1	0.561
KBTBD7	SQSTM1	0.553	0.138
LLGL1	SQSTM1	0.519	0.146
PRKCZ	RGL1	0.502
BEGAIN	PARD6B	0.455
ZNF3	LLGL2	0.446	0.054
PARD6B	NIPSNAP2	0.439	0.094	structurally_consistent (Q05513)
BEGAIN	LLGL2	0.401
PARD3	PTPN21	0.357	0.062
PTPN21	PRKCZ	0.357	0.148
TEFM	PARD6G	0.356
PARD6G	RGL1	0.35
BEGAIN	LLGL1	0.349
PRKCI	BEGAIN	0.343
TEFM	LLGL1	0.34	0.026
PARD6B	RGL1	0.333
KBTBD7	NIPSNAP2	0.327	0.12
PTPN21	PRKCI	0.324	0.104
KBTBD7	ZNF3	0.234	0.146
ZNF3	SQSTM1	0.222	0.256891719745
PTPN21	LLGL1	0.217	0.056
PTPN21	LLGL2	0.215	0.09
PARD6B	TMEM160	0.194	0.066
ZNF3	PARD6A	0.192
PARD3	TMEM160	0.187	0.044
TEFM	SQSTM1	0.183	0.132
TEFM	NIPSNAP2	0.167	0.16
PRKCI	RGL1	0.164
TEFM	ZNF3	0.164	0.08
TEFM	LLGL2	0.154	0.03
TEFM	TMEM160	0.152	0.092
KBTBD7	PTPN21	0.147	0.078
LLGL2	SQSTM1	0.137	0.098
KBTBD7	RGL1	0.134
PARD3	NIPSNAP2	0.123	0.028
TEFM	PRKCI	0.112	0.03
PARD6G	NIPSNAP2	0.099
KBTBD7	BEGAIN	0.096
BEGAIN	NIPSNAP2	0.074
BEGAIN	TMEM160	0.074
PARD3	PARD6G	0.07
PTPN21	NIPSNAP2	0.068	0.082
BEGAIN	SQSTM1	0.066
PARD3	PARD6A	0.063
ZNF3	PARD6G	0.055
LLGL1	RGL1	0.052
PARD3	ZNF3	0.049	0.064
PTPN21	PARD6G	0.046
PARD6G	SQSTM1	0.042		mutually_exclusive (Q05513)
PARD3	SQSTM1	0.019	0.15041025641
PARD3	KBTBD7	0.017	0.094
PTPN21	SQSTM1	0.016	0.214633540373
TEFM	PRKCZ	0.016	0.124
RGL1	NIPSNAP2	0.014
ZNF3	PRKCZ	0.013	0.158
SQSTM1	KCNMB2	0.005
RGL1	SQSTM1	0.005

Related Complexes

Genename	Complexes
TMEM160	huMAP3_04790.1 huMAP3_10212.1 huMAP3_10344.1 huMAP3_11950.1
KCNMB2	huMAP3_04790.1 huMAP3_10212.1 huMAP3_10344.1 huMAP3_11950.1 huMAP3_14172.1
KBTBD7	huMAP3_00629.1 huMAP3_02218.1 huMAP3_05227.1 huMAP3_05836.1 huMAP3_09468.1 huMAP3_10212.1 huMAP3_10938.1 huMAP3_12987.1
PRKCZ	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08694.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6G	huMAP3_01634.1 huMAP3_01836.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1 huMAP3_14802.1
LLGL1	huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
LLGL2	huMAP3_03500.1 huMAP3_05836.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
RGL1	huMAP3_03500.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_11897.1 huMAP3_12987.1 huMAP3_14124.1
PARD3	huMAP3_00531.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_06269.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09726.1 huMAP3_09810.1 huMAP3_10212.1 huMAP3_10898.1 huMAP3_12987.1 huMAP3_14118.1
ZNF3	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PRKCI	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
NIPSNAP2	huMAP3_04272.1 huMAP3_06110.1 huMAP3_07433.1 huMAP3_08977.1 huMAP3_10212.1
PTPN21	huMAP3_00803.1 huMAP3_02230.1 huMAP3_03367.1 huMAP3_03400.1 huMAP3_05769.1 huMAP3_09726.1 huMAP3_09949.1 huMAP3_10212.1 huMAP3_10383.1 huMAP3_11656.1 huMAP3_12615.1 huMAP3_12987.1 huMAP3_13342.1
PARD6B	huMAP3_03400.1 huMAP3_05806.1 huMAP3_05836.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6A	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
SQSTM1	huMAP3_04272.1 huMAP3_08977.1 huMAP3_10212.1
TEFM	huMAP3_00629.1 huMAP3_02218.1 huMAP3_04952.1 huMAP3_05227.1 huMAP3_05836.1 huMAP3_09468.1 huMAP3_10212.1 huMAP3_10938.1
BEGAIN	huMAP3_02982.1 huMAP3_03502.1 huMAP3_04756.1 huMAP3_08345.1 huMAP3_08694.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_10798.1 huMAP3_12987.1 huMAP3_13335.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10212.1

Complex Portal: CPX-24116