hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10215.1
Complex Portal: CPX-14396
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC9A5 | Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) | 5 | UniProt NCBI |
| DIRAS2 | GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2) | 4 | UniProt NCBI |
| ZNF274 | Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2) | 5 | UniProt NCBI |
| UNC13B | Protein unc-13 homolog B (Munc13-2) (munc13) | 5 | UniProt NCBI |
| RAP1GDS1 | Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) | 5 | UniProt NCBI |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | 5 | UniProt NCBI |
| DIRAS1 | GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Ras-related inhibitor of cell growth) (Rig) (Small GTP-binding tumor suppressor 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04722 | 0.0496787672026 | 0.285714285714 | RAC1 ZNF274 | Neurotrophin signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RAP1GDS1 | DIRAS1 | 1.0 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAP1GDS1 | DIRAS2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLC9A5 | DIRAS1 | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAP1GDS1 | RAC1 | 0.99 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UNC13B | DIRAS1 | 0.982 | 0.114 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DIRAS2 | DIRAS1 | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZNF274 | DIRAS1 | 0.968 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DIRAS2 | UNC13B | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RAC1 | DIRAS1 | 0.433 |
mutually_exclusive (P52306)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RAP1GDS1 | UNC13B | 0.418 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAP1GDS1 | SLC9A5 | 0.324 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAC1 | UNC13B | 0.026 | bioplex3_WMM WMM_only |
Related Complexes