hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10228.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNF224 | Zinc finger protein 224 (Bone marrow zinc finger 2) (BMZF-2) (Zinc finger protein 233) (Zinc finger protein 255) (Zinc finger protein 27) (Zinc finger protein KOX22) | 5 | UniProt NCBI |
| LRP1B | Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) | 5 | UniProt NCBI |
| VLDLR | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | 5 | UniProt NCBI |
| LRPAP1 | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | 5 | UniProt NCBI |
| LRP2 | Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) | 5 | UniProt NCBI |
| LRP8 | Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) | 5 | UniProt NCBI |
| LRP1 | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005041 | 3.78174024332e-10 | 0.714285714286 | LRP2 LRP8 LRP1B LRP1 VLDLR | low-density lipoprotein particle receptor activity |
| GO:0030228 | 8.24918622139e-10 | 0.714285714286 | LRP2 LRP8 LRP1B LRP1 VLDLR | lipoprotein particle receptor activity |
| GO:0038024 | 2.04443040639e-07 | 0.714285714286 | LRP2 LRP8 LRP1B LRP1 VLDLR | cargo receptor activity |
| KEGG:04979 | 3.71434707508e-05 | 0.428571428571 | LRP1 LRPAP1 LRP2 | Cholesterol metabolism |
| REAC:R-HSA-975634 | 0.000127854887848 | 0.428571428571 | LRP8 LRP2 LRP1 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.000159603643781 | 0.428571428571 | LRP8 LRP2 LRP1 | Metabolism of fat-soluble vitamins |
| GO:0006897 | 0.000304470789292 | 0.857142857143 | LRPAP1 LRP2 LRP1B LRP8 VLDLR LRP1 | endocytosis |
| GO:0006898 | 0.000362248975627 | 0.714285714286 | LRPAP1 LRP1 LRP1B LRP2 VLDLR | receptor-mediated endocytosis |
| GO:0034185 | 0.000738757615619 | 0.428571428571 | LRP8 VLDLR LRP1 | apolipoprotein binding |
| REAC:R-HSA-2187338 | 0.000976813602208 | 0.428571428571 | LRP8 LRP2 LRP1 | Visual phototransduction |
| WP:WP5110 | 0.000977649559067 | 0.285714285714 | VLDLR LRP1 | Familial hyperlipidemia type 3 |
| GO:0045056 | 0.00152694380207 | 0.428571428571 | LRP1 LRPAP1 LRP2 | transcytosis |
| GO:0098657 | 0.00153212690263 | 0.857142857143 | LRPAP1 LRP2 LRP1B LRP8 VLDLR LRP1 | import into cell |
| GO:0043235 | 0.00258051041122 | 0.714285714286 | LRP2 LRP8 LRP1B LRP1 VLDLR | receptor complex |
| REAC:R-HSA-196854 | 0.00799265153172 | 0.428571428571 | LRP8 LRP2 LRP1 | Metabolism of vitamins and cofactors |
| GO:0038025 | 0.00983221512175 | 0.285714285714 | LRP8 VLDLR | reelin receptor activity |
| GO:0097242 | 0.016587316136 | 0.428571428571 | LRP1 LRPAP1 LRP2 | amyloid-beta clearance |
| REAC:R-HSA-9709957 | 0.0184779747348 | 0.428571428571 | LRP8 LRP2 LRP1 | Sensory Perception |
| GO:0030229 | 0.0294899169624 | 0.285714285714 | LRP8 VLDLR | very-low-density lipoprotein particle receptor activity |
| GO:1905167 | 0.0294899169624 | 0.285714285714 | LRP2 LRP1 | positive regulation of lysosomal protein catabolic process |
| WP:WP5304 | 0.0321598473831 | 0.285714285714 | LRPAP1 LRP1 | Cholesterol metabolism |
| CORUM:7535 | 0.0499958217778 | 0.142857142857 | LRP1 | CD44-LRP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LRP1B | LRPAP1 | 0.995 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP2 | LRPAP1 | 0.99 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP8 | LRPAP1 | 0.979 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VLDLR | LRPAP1 | 0.966 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRPAP1 | LRP1 | 0.96 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRP1B | ZNF224 | 0.953 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ZNF224 | LRP2 | 0.946 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRP1B | LRP1 | 0.778 | 0.082 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| LRP1B | LRP2 | 0.673 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP2 | LRP1 | 0.575 | 0.254 | bioplex_WMM bioplex3_WMM WMM_only |
| VLDLR | LRP2 | 0.497 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only |
| ZNF224 | LRP1 | 0.489 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VLDLR | LRP1B | 0.194 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP1B | 0.19 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | VLDLR | 0.172 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
| VLDLR | LRP1 | 0.117 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only |
| LRP8 | LRP1 | 0.111 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only |
| ZNF224 | LRPAP1 | 0.087 | bioplex3_HEK293 bioplex () | |
| LRP8 | LRP2 | 0.066 | 0.086 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes