hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10229.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD18 | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | 5 | UniProt NCBI |
| SLF2 | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | 5 | UniProt NCBI |
| SLF1 | SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) | 5 | UniProt NCBI |
| UBE2B | Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B) | 5 | UniProt NCBI |
| CD8A | T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a) | 5 | UniProt NCBI |
| UBE2A | Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8866654 | 0.000173933056475 | 0.5 | RAD18 UBE2B UBE2A | E3 ubiquitin ligases ubiquitinate target proteins |
| GO:0031625 | 0.000408118994483 | 0.833333333333 | SLF1 RAD18 UBE2A UBE2B SLF2 | ubiquitin protein ligase binding |
| REAC:R-HSA-8852135 | 0.000453163624664 | 0.5 | RAD18 UBE2B UBE2A | Protein ubiquitination |
| GO:0044389 | 0.000547564742709 | 0.833333333333 | SLF1 RAD18 UBE2A UBE2B SLF2 | ubiquitin-like protein ligase binding |
| GO:0006301 | 0.00949259421943 | 0.5 | RAD18 UBE2B UBE2A | postreplication repair |
| WP:WP5407 | 0.00989727276085 | 0.333333333333 | SLF2 SLF1 | 15q11q13 copy number variation |
| REAC:R-HSA-110314 | 0.0111743831709 | 0.333333333333 | RAD18 UBE2B | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-8866652 | 0.0111743831709 | 0.333333333333 | UBE2A UBE2B | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| GO:0006281 | 0.0113925126082 | 0.833333333333 | SLF1 RAD18 UBE2A UBE2B SLF2 | DNA repair |
| REAC:R-HSA-73893 | 0.0276828753036 | 0.333333333333 | RAD18 UBE2B | DNA Damage Bypass |
| GO:0032446 | 0.0300759059221 | 0.833333333333 | SLF1 RAD18 UBE2A UBE2B SLF2 | protein modification by small protein conjugation |
| GO:0033503 | 0.042122686785 | 0.333333333333 | UBE2A UBE2B | HULC complex |
| GO:0070647 | 0.0491685405756 | 0.833333333333 | SLF1 RAD18 UBE2A UBE2B SLF2 | protein modification by small protein conjugation or removal |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SLF2 | SLF1 | 1.0 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| RAD18 | SLF1 | 1.0 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| CD8A | SLF1 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAD18 | UBE2A | 0.999 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| SLF2 | RAD18 | 0.998 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () | |
| SLF2 | UBE2A | 0.979 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2B | UBE2A | 0.97 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RAD18 | UBE2B | 0.965 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SLF2 | CD8A | 0.931 | bioplex3_WMM WMM_only | |
| RAD18 | CD8A | 0.72 | bioplex3_WMM WMM_only | |
| UBE2A | SLF1 | 0.192 | hein_WMM WMM_only |
Related Complexes