hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10232.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAT2A | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | 5 | UniProt NCBI |
| SARS2 | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | 5 | UniProt NCBI |
| MAT1A | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP704 | 1.1325886453e-05 | 0.666666666667 | MAT1A MAT2A | Methylation pathways |
| WP:WP3580 | 0.000215044561898 | 0.666666666667 | MAT1A MAT2A | Methionine de novo and salvage pathway |
| REAC:R-HSA-156581 | 0.00024538606603 | 0.666666666667 | MAT1A MAT2A | Methylation |
| KEGG:00270 | 0.000788502734463 | 0.666666666667 | MAT1A MAT2A | Cysteine and methionine metabolism |
| WP:WP3940 | 0.00102095428698 | 0.666666666667 | MAT1A MAT2A | One carbon metabolism and related pathways |
| GO:0004478 | 0.00140460216025 | 0.666666666667 | MAT1A MAT2A | methionine adenosyltransferase activity |
| WP:WP2525 | 0.00167805708824 | 0.666666666667 | MAT1A MAT2A | Trans sulfuration one carbon metabolism and related pathways |
| KEGG:01230 | 0.00168280767129 | 0.666666666667 | MAT1A MAT2A | Biosynthesis of amino acids |
| GO:0048269 | 0.00421361424067 | 0.666666666667 | MAT1A MAT2A | methionine adenosyltransferase complex |
| KEGG:01240 | 0.00676143238566 | 0.666666666667 | MAT1A MAT2A | Biosynthesis of cofactors |
| GO:0006556 | 0.00842684400117 | 0.666666666667 | MAT1A MAT2A | S-adenosylmethionine biosynthetic process |
| REAC:R-HSA-156580 | 0.0214696523361 | 0.666666666667 | MAT1A MAT2A | Phase II - Conjugation of compounds |
| CORUM:7197 | 0.0249718442456 | 0.333333333333 | MAT1A | Methionine adenosyltransferase alpha1 beta-v1 |
| REAC:R-HSA-5579024 | 0.0498224659464 | 0.333333333333 | MAT1A | Defective MAT1A causes MATD |
| CORUM:7191 | 0.0499402709677 | 0.333333333333 | MAT2A | Methionine adenosyltransferase alpha2 beta-v1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAT2A | MAT1A | 0.996 | 0.734 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAT2A | SARS2 | 0.986 | 0.026 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes